Immunofluorescent Detection of Antibodies to Ocular Melanomas

Wong, Ira G.; Oskvig, Roger M.

doi:10.1001/archopht.1974.01010010104004

Cited by 26 publications

(8 citation statements)

References 10 publications

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“…In an earlier study (Rahi, 1971(Rahi, , 1973 it was shown that the surface antigens are peculiar to each individual tumour, in contrast to a considerable degree of sharing of intracytoplasmic antigens between one malignant melanoma and another (Wong and Oskvig, 1974). Contrary to our experience, however, the latter workers also reported some sharing of surface antigens in a proportion of their cases.…”

contrasting

confidence: 66%

“…Consequently, the mere demonstration that a patient has antibodies with an affinity for cancer cells does not necessarily constitute evidence of a malignant condition in that patient. In the context of ocular malignant melanomas this casts considerable doubt on claims that cytoplasmic fluorescence of allogeneic melanoma cells can be used as an index of malignancy (Federman et al, 1974;Wong and Oskvig, 1974). Clearly, before such antibody can be accepted as being a response to tumour-specific cytoplasmic antigen it is necessary to exclude the presence of smooth muscle antibodies by testing the patient's serum against preparation of stomach wall, etc.…”

Section: Discussionmentioning

confidence: 99%

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Contractile protein antigens in the cells of malignant melanoma of the choroid and their diagnostic significance.

Rahi¹,

Garner²,

Malaty³

1978

British Journal of Ophthalmology

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contrasting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Contractile protein antigens in the cells of malignant melanoma of the choroid and their diagnostic significance.

Rahi¹,

Garner²,

Malaty³

1978

British Journal of Ophthalmology

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“…Cell mediated immune reactions are considered to play a major role in the control of solid tumors (Rahi & Agarwal, 1977;Char et al 1974;Manor et al 1978). Cellular immunity to uveal melanomas has been demonstrated by a cutaneous hypersensitivity reaction (Wong & Oskvig, 1974), by macrophage electrophoretic mobility (M.E.M.) test , and by macrophage inhibition test (Manor et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Necrosis and lymphocytic infiltration in choroidal melanomas

Kremer¹,

Gilad²,

Kahan

et al. 1991

Acta Ophthalmologica

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Patient survival, tumor lymphocytic infiltration and tumor necrosis were studied and evaluated in 43 enucleated eyes with the same histological diagnosis of spindle 'B' malignant melanoma of the choroid. A significant difference (P less than 0.05) was found between the survival rate of melanoma patients with no evidence of lymphocytic infiltration and/or necrosis in the tumor, compared to those with any evidence of of lymphocytic infiltration and/or tumor necrosis.

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“…Coleman). Wong & Oskvig (1974) and Federman et aL (1974) have demonstrated the presence of ocular melanoma antitumor antibodies by the technique of indirect immunofluorescence of tumor imprints and frozen tissue sections. The demonstration of brain glioma specific antigens (Wahlstrom et al, 1974) coupled with fluorescent antibody techniques holds forth the possibility of developing a serological test to aid in diagnosing optic nerve gliomas.…”

Section: Diagnos~mentioning

confidence: 99%

Tumors of the optic nerve

1976

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This is a review of primary and secondary tumors of the optic nerve. The emphasis is an optic nerve gliomas and meningiomas. Optic nerve gliomas are slowly growing astrocytic neoplasms of the anterior visual pathways, the majority of which occur within the first two decades of life, with equal sex incidence in about 1 of 200,000 patients presenting with eye complaints. The incidence is greater in neurofibromatosis. The typical presentation is visual impairment in a verbal pre-school child with optic canal enlargement and optic atrophy. An intraorbital location of the tumor leads to axial, irreducible, non-pulsatile proptosis. An intracranial location may disturb hypothalamic and pituitary function and produce hydrocephalus. Ocular findings may also include limited motility on a mechanical-restrictive basis, a pupillary relative afferent defect, nystagmus, and variable, non-specific visual field defects. Roentgenographic studies may show concentric unilateral enlargement of the optic canal with preservation of a well corticated margin, a fossa under the anterior clinoid process in continuity with the optic canal ('J'-shaped sella), and findings of increased intracranial pressure. On pathologic examination the tumor is a smooth, fusiform, intradural enlargement of the optic nerve. Histologically there is proliferation of elongated (pilocytic) astrocytes in reticulated patterns with intervening microcystic spaces containing mucosubstance and surrounding reactive hyperplasia of the arachnoid. Mitoses are not found. The diagnosis is clinical X-ray studies and brain scan should be performed. The differential diagnosis is that of unilateral proptosis in a child and includes acute ethmoiditis, hyperthyrobidism, craniostenosis, other neoplasms, Hand-Schuller-Christian disease, and orbital hemorrhage due to trauma. Surgical resection is performed in cases with unilateral optic nerve involvement, the surgical approach being determined by tumor location. Bilateral or chiasmal cases are treated with radiotherapy when progression occurs. Malignant optic nerve gliomas and optic nerve hyperplasia are also discussed. Optic nerve meningiomas arise from the nerve sheath and are to be distinguished from orbital meningiomas arising from ectopic arachnoidal cells or those secondarily involving the orbit by extension from adjacent sites. Up to 80% of orbital meningiomas occur in females, in two age peaks, 25% in the first decade, and the rest in the 5th decade. Meningiomas present with visual loss and may produce proptosis, papilledema and/or optic atrophy, retinal striae, opticociliary shunts, limitation of extra-ocular movements, and lid edema, Signs of von Recklinghausen's disease should be sought. X-rays are the mainstay of diagnosis. Orbital meningiomas are composed of cells in sheets or in whorls with some spindle shaped cells. Calcifications are typical. Usually the dura is penetrated and the orbit invaded. Primary orbital meningiomas are locally infiltrating but do not metastasize. Complete local excision en bloc is recommended...

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Immunofluorescent Detection of Antibodies to Ocular Melanomas

Cited by 26 publications

References 10 publications

Contractile protein antigens in the cells of malignant melanoma of the choroid and their diagnostic significance.

Contractile protein antigens in the cells of malignant melanoma of the choroid and their diagnostic significance.

Necrosis and lymphocytic infiltration in choroidal melanomas

Tumors of the optic nerve

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