Immunofluorescent Studies in Gonadotropin-secreting Bronchogenic Carcinoma

Cottrell, John C.; Becker, Kenneth L.; Moore, Charles F.

doi:10.1093/ajcp/50.4.422

Cited by 24 publications

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“…The great increase in the number of the Leydig cells in our case is comparable to the hyperplasia of these cells in children with hepatomas displaying a gonadotropin-like effect. 6 The severe tubular atrophy which was secondary to mumps orchitis in our case, may have been responsible for the extreme proliferation of interstitial cells in response to stimulation by chorianic gonadotropin.…”

Section: Pathologic Finlhngsmentioning

confidence: 57%

Gonadotropin secreting giant cell carcinoma of the lung

Dailey

Marcuse

1969

Cancer

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A case report of a habitual smoker with pulmonary tuberculosis and carcinoma of the left upper lobe associated with gynecomastia is presented. After excision of the left upper lobe, the patient remained well for 21/2 years but then showed clinical evidence of recurrence and died 6 months later of carcinoma. He had gynecomastia and, during his terminal hospitalization, chorionic gonadotropin was identified in his urine. Postmortem studies revealed giant cell carcinoma of the left lower lobe with widespread metastasis. Assays of extracts from tumor tissue indicated high levels of gonadotropic activity. Morphologic manifestations of endocrinopathy were represented by gynecomastia, interstitial cell hyperplasia of the testes, and presence of “pregnancy‐like” cells in the anterior lobe of the pituitary gland. The mechanism whereby the gynecomastia is produced may be the release of estrogen following long‐term stimulation of the testes by gonadotropin. Atrophy of the seminiferous tubules due to antecedent mumps orchids was a predisposing factor that favored the severe hyperplasia of the interstitial cells.

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Section: Pathologic Finlhngsmentioning

confidence: 57%

Gonadotropin secreting giant cell carcinoma of the lung

Dailey

Marcuse

1969

Cancer

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“…However, there are several reports of HCGproducing bronchogenic carcinoma without evidence of choriocarcinoma (Cottrell, Becker and Moore 1968). The reported cases of HCG-producing tumor include squamous cell carcinoma, adenocarcinoma and oat cell carcinoma.…”

Section: Hcgmentioning

confidence: 99%

An immunohistochemical study of keratin, carcinoembryonic antigen, human chorionic gonadotropin and alpha-fetoprotein in lung cancer.

Kimura

Ghandur-Mnaymen

1985

Tohoku J. Exp. Med.

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Immunohistochemical staining utilizing a peroxidase-antiperoxidase (PAP) technique for keratin, carcinoembryonic antigen (CEA), human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) was performed on paraffin sections from 72 cases of lung cancer obtained at autopsy. Positive reaction was shown in 44% of the cases for keratin, 77% for CEA, and 58% for HCG. AFP was positive in only one case of large cell carcinoma. Keratin was positive in 100% of squamous cell carcinoma, 53% of adenocarcinoma,15% of small cell carcinoma and 45% of large cell carcinoma. CEA showed positive staining in 90% of squamous cell carcinoma, 88% of adenocarcinoma, 58% of small cell carcinoma and 69% of large cell carcinoma. CEA was the most useful tumor marker for detection of all types of lung cancer. HCG was positive in 30% of squamous cell carcinoma, 100% of adenocarcinoma, 23% of small cell carcinoma and 56% of large cell carcinoma. lung cancer ; immunohistochemistry ; keratin ; CEA ; HCG ; AFP Pulmonary carcinoma is divided into four large groups ; squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma. If tumors have morphologically characteristic features such as keratin pearl or glandular structure, it may not be difficult to make the diagnosis of typing. Diagnostic agreement in lung cancer was less than 50% for poorly differentiated tumors, especially in the polygonal small cell carcinoma, large cell carcinoma growing in sheets, poorly differentiated adenocarcinoma with little gland formation, and poorly differentiated squamous cell carcinoma without keratin (Yesner 1978). Unfortunately, these tumors comprise over 50% of all lung cancer (Yesner 1978).The presence of keratin has been directly related to increased squamous

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“…1,3,7,20) Previous immunohistochemical studies on hCG/hCGb-producing bronchogenic carcinomas demonstrated that localization of immunoreactive hCG/hCGb was usually associated with syncytiotrophoblastic giant cells scattered among the non-trophoblastic carcinoma cells. This finding may indicate that the non-trophoblastic carcinoma retrodifferentiated to choriocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Bronchogenic Carcinoma with Human Chorionic Gonadotropin Production Manifesting as Cerebellar Hemorrhage. Case Report.

Sawa

Taomoto

Tamaki

et al. 2001

Neurol. Med. Chir.(Tokyo)

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A 58-year-old male presented with a rare case of brain metastatic bronchogenic carcinoma with human chorionic gonadotropin (hCG) production causing cerebellar hemorrhage with symptoms of nausea, vomiting, and headache. Bronchogenic carcinoma manifesting as gynecomastia had been resected a few months previously. Neurological examination revealed left cerebellar ataxia. Neuroimaging showed multiple cerebellar metastases with cerebellar hemorrhage adjacent to the tentorium. Angiography demonstrated tumor staining fed by the hemispheric branch of the left posterior inferior cerebellar artery. Suboccipital craniectomy was performed. The left cerebellar hematoma was evacuated and the tumor was partially removed to prevent massive intraoperative hemorrhage and avoid brain stem injury. Histological examination showed the resected tumor was large cell carcinoma. hCG was detected in the cerebrospinal fluid and was identified by immunohistochemical staining in tumor cells. The primary lesion of bronchogenic carcinoma showed choriocarcinomatous change because the tumor could produce hCG. The choriocarcinomatous cells with higher metastatic potential formed lesions in the brain, and finally intratumoral hemorrhage occurred producing the rapid development of symptoms.

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Immunofluorescent Studies in Gonadotropin-secreting Bronchogenic Carcinoma

Cited by 24 publications

References 0 publications

Gonadotropin secreting giant cell carcinoma of the lung

Gonadotropin secreting giant cell carcinoma of the lung

An immunohistochemical study of keratin, carcinoembryonic antigen, human chorionic gonadotropin and alpha-fetoprotein in lung cancer.

Metastatic Bronchogenic Carcinoma with Human Chorionic Gonadotropin Production Manifesting as Cerebellar Hemorrhage. Case Report.

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