Immunogenetic analysis of spontaneous autoimmune thyroiditis of obese strain chickens

Kroemer, Guido; Neu, Nikolaus; Kuehr, Thomas; Dietrich, Hermann; Fässler, Reinhard; Hála, K; Wick, Georg

doi:10.1016/0090-1229(89)90172-4

Cited by 32 publications

(10 citation statements)

References 39 publications

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“…Previous results from our laboratory have already shown a deficient immunoneuroendocrine dialogue via the HPA axis in animal models for spontaneous autoimmune diseases, i.e. the Obese strain (OS) and University of California at Davis line 200 (UCD) chickens, animal models for Hashimoto-like autoimmune thyroiditis and progressive systemic sclerosis, respectively, and AID-prone mouse strains (see Table 1) [6,17,[28][29][30]. The influence of an altered immune-neuroendocrine communication via the HPA axis on autoimmunity was also shown in models for experimentally induced autoimmune diseases such as the Lewis/Fisher 344 rat strains, models for experimental autoimmune encephalomyelitis and streptococcal cell wall-induced arthritis [31,32] The multifactorial pathogenesis model of AID postulated by our group is supported by the fact that GC play an important modulatory role in the disease development [18].…”

Section: Discussionmentioning

confidence: 99%

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

Lechner

Dietrich

Santos

et al. 2000

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 99%

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

Lechner

Dietrich

Santos

et al. 2000

Journal of Autoimmunity

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“…Essential and modulatory genes determine the development and severity of each case [1,2], but the final outcome is, to some degree, also modified by non-essential factors [3,4], the elucidation of which is im portant for the establishment of effective AID therapies. Well-known examples of such nonessential modulatory factors in AID arc sex hormones and glucocorticoids, which determine the final outcome of a given AID [5].…”

Section: Introductionmentioning

confidence: 99%

Disturbed Immuno-Endocrine Communication via the Hypothalamo-Pituitary-Adrenal Axis in Autoimmune Disease

Dietrich

Herold

et al. 1993

Int Arch Allergy Immunol

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Previous studies in our laboratory demonstrated an altered immuno-endocrine feedback communication via the hypothalamo-pituitary-adrenal (HPA) axis, which may be an important modulatory factor in the development of spontaneous autoimmune thyroiditis in Obese strain (OS) chickens. These birds show a significantly lower, or even absent, increase in serum glucocorticoid levels in response to an intravenous injection of antigen or conditioned medium (CM) from mitogen-stimulated spleen cells known to contain glucocorticoid-increasing factors (GIFs), notably interleukin-1 (IL-1). The present study was aimed at investigating this feedback regulation in animal models with spontaneous systemic autoimmune diseases, such as the UCD-200 chicken, which serves as a model for human scleroderma, and various murine lupus models. In contrast to OS chickens, UCD-200 chickens displayed a nearly normal plasma corticosterone surge in response to CM, and IL-1 was again identified as the primary GIF in CM. Recombinant IL-1 also induced a drastic increase in plasma corticosterone levels in various strains of normal mice. A similar increase was observed in the bacterial lipopolysaccharide-resistant C3H/HeJ strain, thus excluding the possibility of bacterial endotoxin contamination. However, in young lupus-prone (NZB/W)F1 and MRL/MP-lpr mice, a significantly lower increase in plasma corticosterone levels was observed after injection of recombinant IL-1, suggesting a deficient immuno-endocrine communication via the HPA loop in this instance as well. Detailed studies to identify further cytokines with GIF activity in the avian and murine systems showed that both IL-6 and tumor necrosis factor-α could induce increased plasma corticosterone levels in mice, but not in chickens. IL-3, IL-8, transforming growth factor-β, interferon-γ and granulocyte-macrophage colony-stimulating factor were devoid of GIF activity in both chickens and mice.

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“…Finally, in the obese strain of chicken which shows spontaneous thyroiditis, several genes are involved, including MHC genes and genes coding for defective thyroid function and for abnormal sensitivity to disease induced by antibody transfer [59]. Conversely, no role has been found for thyroglobulin abnormalities.…”

Section: Insulin Gene and Igfl-related Gene Polymorphismsmentioning

confidence: 99%

Genetics of autoimmune endocrine diseases

Bach

Caillat‐Zucman

1993

Springer Semin Immunopathol

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Immunogenetic analysis of spontaneous autoimmune thyroiditis of obese strain chickens

Cited by 32 publications

References 39 publications

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

Disturbed Immuno-Endocrine Communication via the Hypothalamo-Pituitary-Adrenal Axis in Autoimmune Disease

Genetics of autoimmune endocrine diseases

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