Immunogenetic Indicators as Markers of Aggressive Flow and Efficiency of Basic Therapy in Rheumatoid Arthritis in Children

Abstract

The immunological and immunogenetic features of juvenile rheumatoid arthritis in the Kyrgyz population are studied for the first time. The study was conducted in 30 healthy children and 67 patients aged 3 to 16 years. The method of rosette formation was used. Associative links were established in the systemic form of juvenile rheumatoid arthritis with histocompatibility antigens in the HLA Cw5, B12 system, and the B15, A2, A9 antigens with high activity of the process, early development of bone and cartilage destruction and functional impairments. In the first 6 months of disease, it recommended the appointment of an aggressive baseline therapy.

Efficiency in the treatment of juvenile rheumatoid arthritis

“…За последние 10 лет в Кыргызстане сохраняется тенденция роста болезней костномышечной системы (+93,3%), в том числе -ревматоидного артрита у детей (+52%). Инвалидность в связи с ювенильным артритом выросла на 40,7% [1][2][3][4][5][6][7][8][9][10].…”