Immunogenetic studies of species and of species hybrids in doves, and the separation of species‐specific substances in the backcross

Irwin, M. R.; Cole, Leon J.

doi:10.1002/jez.1400730106

Cited by 58 publications

(14 citation statements)

References 17 publications

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“…The antisera were absorbed and tested for agglutination of the various cells a t a dilution of 1/20 in saline, with the exception of the livia anti-risoria serum which was absorbed and tested at 1/3. Further details of these serological technics have been published previously (IRWIN and COLE [6], IRWIN [5]). In the agglutination tests, complete absence of clumping constituted a negative test.…”

Section: Methodsmentioning

confidence: 99%

An Embryo Specific Red Cell Antigen in a Dove Species, *Streptopelia Risoria**

Osterhoudt

Irwin

1965

Vox Sanguinis

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Summary The erythrocytes of all embryos tested to date of a dove species, Streptopelia risoria, have carried an “embryo antigen” during the first seven days of incubation. It gradually disappeared and was not observed beyond the fourth day after hatching. Peculiarly, this embryo antigen was detected by the use of antisera produced against the cells of backcross hybrids carrying one of the antigenic characters (ch‐4) that differentiate S. chinensis from risoria. One possible explanation is that the antibodies were directed against a contrasting character in risoria to ch‐4, and this character is expressed on the cells of the embryos, not on those of the adults. Résumé Jusqu'à aujourd'hui les erythrocytes de tous les embryons d'une espèce de pigeon, le streptopelia risoria, comportent un antigène embryonnaire pendant les 7 premiers jours d'incubation. Il disparaît graduellement et n'est plus observé 4 jours après l'éclosion. Cet antigène embryonnaire a pu être curieusement décelé en utilisant des anti‐sérums produits contre des erythrocytes d'hybrides comportant un des caractères antigéniques (ch‐4) qui différencie le S. chinensis du risoria. L'explication possible de ce phénomène est que les anticorps sont dirigés contre un caractère contrastant du risoria à l'égard de ch‐4, et ce caractère s'exprime sur les cellules de l'embryon mais non sur les cellules de l'animal adulte. Zusammenfassung In den Erythrozyten sämtlicher bisher untersuchten Embryonen einer Taubenart, Streptopelia risoria, gelang es während der ersten sieben Tage der Bebrütung, ein «Embryo‐Antigen» nachzuweisen. Mit zunehmender Entwicklung verschwindet es; spater als vier Tage nach dem Ausschlüpfen kann es nicht mehr nachgewiesen werden. Eigentümlicherweise wurde dieses Antigen bei Verwendung von Antiseren entdeckt, welche gegen Zellen von Rückkreuzungen gerichtet waren, welche ein Antigen (ch‐4) enthielten, welches die S. chinensis von der risoria unterscheidet. Die Befunde lassen sich am besten dadurch erklären, daß diese Antikörper sich gegen ein Merkmal richten, welches die risoria an Stelle von ch‐4 aufweist, wobei dieses nur in den embryonalen Zellen, nicht aber in denjenigen erwachsener Individuen zur Ausprägung gelangt.

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Section: Methodsmentioning

confidence: 99%

An Embryo Specific Red Cell Antigen in a Dove Species, *Streptopelia Risoria**

Osterhoudt

Irwin

1965

Vox Sanguinis

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“…Briefly, it was very easy to obtain a reagent, from antisera produced in rabbits, which would react specifically with the erythrocytes of any species in comparison with the cells of another, following absorption of an antiserum to one species by the cells of a second. The first report of these tests showed that the cells of a few species hybrids possessed most, but not all, of the species-specific and common antigenic characters of both parental species (Irwin & Cole, 1936). (Incidentally, this paper marked the first use of the term 'immunogenetics', representing a marriage between the techniques and principles of genetics and immunology.…”

Section: Recognition Of Species-specific Antigensmentioning

confidence: 97%

Comments on the early history of immunogenetics¹²

1974

Animal Blood Groups and Biochemical Genetics

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“…Hybrids between different avian species have been useful in the study of genetic control of blood group [ 1,2] and isozyme markers [3-51. While several of the latter studies have examined developmentally regulated enzyme markers, few studies have utilized avian hybrids to study gene expression related to processes of development and differentiation of hematopoietic cells.…”

Section: Introductionmentioning

confidence: 99%

Avian developmental antigens: Expression on erythrocytes of chickens, Japanese quail, and quail‐chicken hybrids

1984

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Monoclonal and polyclonal antibodies were used to examine the expression of three erythroid developmental antigen systems in the chicken, Japanese quail, and quail‐chicken hybrid. Chicken fetal antigen (CFA), quail fetal antigen (QFA), and chicken adult antigen (CAA) each represent a series of cell‐surface glycorproteins associated with the development of avian hematopoietic cells. Monoclonal anti‐CFA antibodies from clones 190‐4 and 288‐1.1.1.2 supernatants were shown to react against epitopes associated with CFA determinants 8 and 2, respectively. Using complement‐mediated microcytotoxicity, these reagents permitted the identification of different erythroid subpopulations in the neonatal chicken and hybrid; therefore, heterogeneity in cell surface CFA determinants among mature peripheral erythrocytes should serve as a useful tool for analyzing erythroid development. In the case of CAA, erythrocytes from adult hybrids were found to express the same complement of CAA determinants identified in the chicken, and CAA appeared much earlier in the hybrid than in either of the parental species. Similarly, two species‐restricted fetal antigens associated with similar glycoproteins, CFA8 and QFA, had similar developmental profiles in their respective species, the chicken and quail. In contrast, these antigens were dominantly expressed but exhibited different developmental profiles on erythrocytes from the hybrids. While quail‐chicken hybrids exhibited apparent genomic interactions in the expression of these developmental antigens, no evidence for the existence of hybrid‐specific fetal antigens was obtained.

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Immunogenetic studies of species and of species hybrids in doves, and the separation of species‐specific substances in the backcross

Cited by 58 publications

References 17 publications

An Embryo Specific Red Cell Antigen in a Dove Species, *Streptopelia Risoria**

An Embryo Specific Red Cell Antigen in a Dove Species, *Streptopelia Risoria**

Comments on the early history of immunogenetics¹²

Avian developmental antigens: Expression on erythrocytes of chickens, Japanese quail, and quail‐chicken hybrids

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Immunogenetic studies of species and of species hybrids in doves, and the separation of species‐specific substances in the backcross

Cited by 58 publications

References 17 publications

An Embryo Specific Red Cell Antigen in a Dove Species, Streptopelia Risoria*

An Embryo Specific Red Cell Antigen in a Dove Species, Streptopelia Risoria*

Comments on the early history of immunogenetics12

Avian developmental antigens: Expression on erythrocytes of chickens, Japanese quail, and quail‐chicken hybrids

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Product

Resources

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An Embryo Specific Red Cell Antigen in a Dove Species, *Streptopelia Risoria**

An Embryo Specific Red Cell Antigen in a Dove Species, *Streptopelia Risoria**

Comments on the early history of immunogenetics¹²