Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with <i>Dermatophagoides </i>spp.‐sensitive asthma in a sample of the Venezuelan population

Lara-Marquez, Maria Luz; Yunis, Jörge J.; Layrisse, Z.; Ortega, Francisco; Carvallo-Gil, E; Montagnani, S.; Nj, Makhatadze; Pocino, M; Granja, Clarissa; Yunis, Emilio

doi:10.1046/j.1365-2222.1999.00461.x

Cited by 56 publications

(41 citation statements)

References 48 publications

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“…Specifically, DQB1*0201 allele has shown association with high levels of specific IgE to olive tree pollen antigens Ole e 1 and Ole e 3, 31 as well as to susceptibility to isocyanate-induced asthma 32 . DQB1*0202 has been related to nasal polyposis, 33 DRB1*0301 to poor response to grass pollen specific immunotherapy, 34 and DRB1*1101 to mitesensitive bronchial asthma, 35 as well as to high levels of specific IgE against Parietaria major allergen Par o 1. 36 More interestingly, the high frequency of DRB1*0701 (DR7) phenotype among patients with spina bifida with latex or hevein responsiveness, 16 together with the protective effect that-according to our results-DRB1*0701 seems to exert against latex-fruit allergy, could further explain the lower prevalence of latex-fruit allergy in patients with latex allergy and spina bifida compared with patients without spina bifida.…”

Section: Discussionmentioning

confidence: 99%

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Blanco¹,

Sánchez-García²,

Torres-Galván³

et al. 2004

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Blanco¹,

Sánchez-García²,

Torres-Galván³

et al. 2004

Journal of Allergy and Clinical Immunology

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“…A study of a Venezuelan population suggested that the HLA-DRB1*11:01 HLA-DQA1*05:01 HLA-DQB1*03:01 haplotype is associated with allergic asthma, which confers susceptibility to the development of asthma with mite sensitization. Furthermore, it concluded that HLA-C7 could play a protective role in the development of the allergic phenotype [34]. …”

Section: Discussionmentioning

confidence: 99%

“…A study conducted in 2010 reported that the progression of asthma from initial symptoms to disease was slower among children carrying the HLA-DRB1*11 and DQB1*0301 antigens [33]. These antigens were reported as susceptibility markers for the development of allergic asthma in a Venezuelan population [34]. The HLA-DRB1*11 antigen presented a lower frequency among nonallergic patients [35].…”

Section: Introductionmentioning

confidence: 99%

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Takejima

Agondi²,

Rodrigues³

et al. 2017

Int Arch Allergy Immunol

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Background: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. Methods: A total of 109 patients with asthma were prospectively followed during 2 years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. The control group comprised 297 deceased donors of solid organs. Patients' features and HLA class I and II genotypes were assessed and compared. Results: This study showed different features between asthma phenotypes. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. New associations between the HLA genotypes and allergic and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. Conclusions: Allergic and nonallergic asthma have distinct phenotypic and genotypic features. New associations between asthma phenotypes and HLA class I and II were identified.

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“…Others have associated this allele with asthma and pollen sensitization in European cohorts [16,17]. The HLA genes have shown consistent linkage to asthma and atopy-associated phenotypes in several studies (reviewed in [18]) and may be a major locus influencing allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

Allergic women show reduced T helper type 1 alloresponses to fetal human leucocyte antigen mismatch during pregnancy

Prescott¹,

Breckler²,

Witt

et al. 2009

Clinical and Experimental Immunology

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SummaryLow-level alloreactivity between mother and fetus may provide stimulation for fetal T helper type 1 (Th1) cell immune maturation. This study explored the effects of human leucocyte antigen (HLA) mismatch on materno-fetal interactions detected as cytokine responses and lymphoproliferation in mixed lymphocyte reactions, and whether this was altered in allergic women (n = 62) who have a Th2 propensity compared with non-allergic women (n = 65). HLA-DRb1 mismatch was associated with significantly increased Th1 interferon (IFN)-g, Th2 interleukin (IL)-13 and lymphoproliferative responses by both mothers and fetuses. Allergic women showed significantly lower IFN-g Th1 production in response to HLA-DRb1 mismatch. The infants of these women also showed significantly lower IL-10 and lower IFN-g production relative to IL-13. Both HLA-DRb1 mismatch and maternal allergy had significant independent effects on maternal IFN-g Th1 responses. Maternal allergy modifies HLA-mediated alloreactivity between the mother and the fetus, reducing Th1 activation. This may affect the cytokine milieu at the maternofetal interface and could be implicated in the attenuated Th1 responses observed commonly in infants of atopic mothers.

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Immunogenetics of atopic asthma: association of DRB11101 DQA10501 DQB10301 haplotype with Dermatophagoides* spp.‐sensitive asthma in a sample of the Venezuelan population

Cited by 56 publications

References 48 publications

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Allergic women show reduced T helper type 1 alloresponses to fetal human leucocyte antigen mismatch during pregnancy

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Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.‐sensitive asthma in a sample of the Venezuelan population

Cited by 56 publications

References 48 publications

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Allergic women show reduced T helper type 1 alloresponses to fetal human leucocyte antigen mismatch during pregnancy

Contact Info

Product

Resources

About

Immunogenetics of atopic asthma: association of DRB11101 DQA10501 DQB10301 haplotype with Dermatophagoides* spp.‐sensitive asthma in a sample of the Venezuelan population