Immunogenetics of Lupus Erythematosus

Ünlü, Begüm; Türsen, Ümit; Jabalameli, Navid; Abdollahimajd, Fahimeh; Rajabi, Fateme

doi:10.1007/978-3-030-92616-8_9

Cited by 2 publications

(1 citation statement)

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“…Gene-wide association studies have found more than one hundred risk loci for SLE [5]. The problem is related to its multi-genic nature and the complex way of inheritance [6].…”

Section: Introductionmentioning

confidence: 99%

The Impact of the IL-10 Gene Polymorphism on mRNA Expression and IL-10 Serum Concentration in Polish Lupus Patients

Żak-Gołąb,

Cieślik,

Siekiera

et al. 2024

IJMS

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Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of autoantibodies against a lot of nuclear components. Despite many studies on the genetic background of this disease, the pathogenesis remains unclear. The aim of the study is to comprehensively evaluate the polymorphism of the IL-10 promoter gene, its mRNA expression, and the serum IL-10 concentration of SLE female patients and females age-matched controls. Analyzing the association between the level of the tested cytokine and the polymorphism genotype-1082; -819; -592, we found statistically higher serum IL-10 levels in SLE patients compared to in healthy controls (11.9 ± 2.2 pg/mL vs. 9.4 ± 1.7 pg/mL, accordingly; p < 0.0001). We did not find statistically significant differences in the gene polymorphism of IL-10 among SLE patients and controls. The most significant observation derived from our study is that IL-10 mRNA transcripts are upregulated in SLE patients compared to in healthy controls (p < 0.0001). According to our results, the presence of the IL-10 genetic polymorphism has no clinical significance for the development of SLE, and subsequent differences in mRNA and IL-10 concentration results from the influence of other factors which should be the subject of further research.

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“…Gene-wide association studies have found more than one hundred risk loci for SLE [5]. The problem is related to its multi-genic nature and the complex way of inheritance [6].…”

Section: Introductionmentioning

confidence: 99%