Immunogenic Chemotherapy Using Cyclophosphamide and Gemcitabine

Boosting effect of pre-existing immunity on anti-cancer immunotherapies

“…This strategy, however, appears inherently flawed since standard chemotherapy regimens are so strongly immunotoxic that patients, left by chemotherapy with an impaired immune system, are often unable to benefit from immunotherapy [16,17]. Nonetheless, a few chemotherapeutic agents, especially when employed at doses much lower than those usually prescribed, have shown immunomodulatory effects [18]. Physical ablative techniques, radiotherapy in particular, have shown to cause immunogenic cancer cell death with lesser debilitating effects on the immune system.…”