Immunogenic exosome-encapsulated black phosphorus nanoparticles as an effective anticancer photo-nanovaccine

Liu, Quan; Fan, Taojian; Zheng, Yuanyuan; Yang, Shengli; Yu, Zhiqiang; Duo, Yanhong; Zhang, Yuhua; Adah, Dickson; Shi, Liangliang; Sun, Zhe; Wang, Dou; Xie, Jianlei; Wu, Hong; Wu, Zongze; Ge, Chenchen; Qiao, Liang; Wei, Chaoying; Huang, Luodan; Yan, Qiaoting; Yang, Qin; Bao, Shaowen; Liu, Liping; Zhang, Han

doi:10.1039/d0nr05953f

Cited by 71 publications

(53 citation statements)

References 53 publications

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“…Since tumor cell derived exosomes, which carried tumor-specific antigens, could stimulate immune responses, they were explored to combine with PTT. In the study by Liu and co-workers 52 , exosomes obtained from tumor-bearing mice after PTT (hEX) were used as tumor antigens and carriers for black phosphorus quantum dots (BPQDs). In this nanoplatform (hEX@BP), hEX could protect BPQDs, the photothermal agents from rapid degradation and clearance.…”

Section: Nano-based Ptt Combined With Antigens To Induce Host Immune Responsesmentioning

confidence: 99%

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

et al. 2021

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Cancer has been a great threat to humans for decades. Due to the limitations of monotherapy, combinational therapies such as photothermal therapy (PTT) and immunotherapy have gained increasing attention with expectation to overcome the shortfalls of each other and obtain satisfactory therapeutic outcomes. PTT can inhibit primary tumors by thermal ablation but usually fails to achieve complete eradication and cannot prevent metastasis and recurrence. Meanwhile, the efficacy of immunotherapy is usually attenuated by the weak immunogenicity of tumor and the immunosuppressive tumor microenvironment (ITM). Therefore, many recent studies have attempted to synergize PTT with immunotherapy in order to enhance the therapeutic efficacy. In this review, we aim to summarize the cutting-edge strategies in combining nano-based PTT with immunotherapy for cancer treatment. Herein, the combination strategies were mainly classified into four categories, including 1) nano-based PTT combined with antigens to induce host immune responses; 2) nano-based PTT in combination with immune adjuvants acting as in situ vaccines; 3) nano-based PTT synergized with immune checkpoint blockade or other regulators to relieve the ITM; 4) nano-based PTT combined with CAR-T therapy or cytokine therapy for tumor treatment. The characteristics of various photothermal agents and nanoplatforms as well as the immunological mechanisms for the synergism were also introduced in detail. Finally, we discussed the existing challenges and future prospects in combined PTT and immunotherapy.

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Section: Nano-based Ptt Combined With Antigens To Induce Host Immune Responsesmentioning

confidence: 99%

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

et al. 2021

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“…Recently, reports have also provided preclinical and patient data supporting positive immune modulatory effects of hyperthermia [65]. A study by Liu and colleagues [92] has shown the utility of nanotechnology-based photothermal therapy (PTT) to enhance the activity of a tumor vaccine (hEX@BP) prepared by encapsulating black phosphorus quantum dots (BPQDs) with exosomes (hEX) in the lung cancer model. Another study combined BPQDs with neoantigens in liposomes to produce a more efficacious immune response from a vaccine [15].…”

Section: Photothermal Vaccinesmentioning

confidence: 99%

Neoantigen Cancer Vaccines: Generation, Optimization, and Therapeutic Targeting Strategies

et al. 2022

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Alternatives to conventional cancer treatments are highly sought after for high-risk malignancies that have a poor response to established treatment modalities. With research advancing rapidly in the past decade, neoantigen-based immunotherapeutic approaches represent an effective and highly tolerable therapeutic option. Neoantigens are tumor-specific antigens that are not expressed in normal cells and possess significant immunogenic potential. Several recent studies have described the conceptual framework and methodologies to generate neoantigen-based vaccines as well as the formulation of appropriate clinical trials to advance this approach for patient care. This review aims to describe some of the key studies in the recent literature in this rapidly evolving field and summarize the current advances in neoantigen identification and selection, vaccine generation and delivery, and the optimization of neoantigen-based therapeutic strategies, including the early data from pivotal clinical studies.

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“…encapsulated BPQDs with exosomes (hEX) and found that hEX@BP showed evident tumor cells inhibition in a mice subcutaneous lung cancer model. When combined with photothermal therapy, hEX@BP got a more evident inhibitory effects against tumor cells ( 41 ), demonstrating great potentials for clinical applications.…”

Section: Bioapplications Of Qds In Lungmentioning

confidence: 99%

Applications and Immunological Effects of Quantum Dots on Respiratory System

et al. 2022

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Quantum dots (QDs), are one kind of nanoscale semiconductor crystals with specific electronic and optical properties, offering near-infrared mission and chemically active surfaces. Increasing interest for QDs exists in developing theranostics platforms for bioapplications such as imaging, drug delivery and therapy. Here we summarized QDs’ biomedical applications, toxicity, and immunological effects on the respiratory system. Bioapplications of QDs in lung include biomedical imaging, drug delivery, bio-sensing or diagnosis and therapy. Generically, toxic effects of nanoparticles are related to the generation of oxidative stresses with subsequent DNA damage and decreased lung cells viability in vitro and in vivo because of release of toxic metal ions or the features of QDs like its surface charge. Lastly, pulmonary immunological effects of QDs mainly include proinflammatory cytokines release and recruiting innate leukocytes or adaptive T cells.

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Immunogenic exosome-encapsulated black phosphorus nanoparticles as an effective anticancer photo-nanovaccine

Abstract: Tumor vaccines are a promising form of cancer immunotherapy, but difficulties, such as neo-antigen identification, activation of immune cells, and tumor infiltration prevent their clinical breakthrough. Interestingly, nanotechnology-based photothermal therapy...

Cited by 71 publications

References 53 publications

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

Neoantigen Cancer Vaccines: Generation, Optimization, and Therapeutic Targeting Strategies

Applications and Immunological Effects of Quantum Dots on Respiratory System

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