Immunogenicity and Antigenicity of Angiotensin I and II

Vallotton, Michel B.

doi:10.1007/978-3-642-65600-2_9

Cited by 7 publications

(4 citation statements)

References 62 publications

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“…These peptides are immunologically and pharmacologically similar to [Ile 5 ]Ang I (molecular weight 1300 daltons) and have molecular weights ranging between 1300 and 2200 daltons. Since integrity of the carboxy terminal structure of Ang I is necessary for recognition by the Ang I antibody (Vallotton, 1974) and by the receptors of the resultant Ang II (Khosla et al, 1974), these observations suggest that the CSF-derived Ang I-lp are similar in their carboxy terminal structures to Ang I. Furthermore, since many of the Ang I-Jp appear to have molecular weights greater than that of Ang I, it is likely that these Ang I-Jp represent analogues of Ang I that contain amino terminal extensions.…”

Section: Discussionmentioning

confidence: 99%

Evidence for the existence of a family of biologically active angiotensin I-like peptides in the dog central nervous system.

Husain¹,

Bumpus²,

Smeby³

et al. 1983

Circulation Research

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A family of angiotensin I-like peptides has been derived from endogenous precursors present in dog cerebrospinal fluid after incubation with species homologous renin. These peptides are immunologically and pharmacologically similar to [Ile5]angiotensin I, and have molecular weights ranging between 1300 and 2200 daltons. The presence of precursors in the cerebrospinal fluid able to generate various biologically active angiotensin I-like peptides dissimilar to plasma angiotensin I supports the concept of a local angiotensin I-forming system in the brain.

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Section: Discussionmentioning

confidence: 99%

Evidence for the existence of a family of biologically active angiotensin I-like peptides in the dog central nervous system.

Husain¹,

Bumpus²,

Smeby³

et al. 1983

Circulation Research

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“…It is therefore of interest to compare our findings concerning T cell responses with those measuring AII reactivity using these other types of receptors. Briefly, AII binding by rabbit anti-AII antibody was substantially reduced only by residue substitutions for Phe s, Pro 7, Tyr 4, and to a lesser extent His 8 (4). For biological activity, the most important residues were Phe 8, Pro 7, His 6, Tyr 4, and Arg 2 (11).…”

Section: Comparisons Of T Lymphocyte Responses ~Bith Antibody and Hormentioning

confidence: 99%

Fine specificity of genetic regulation of guinea pig T lymphocyte responses to angiotensin II and related peptides

Thomas¹,

Hsieh²,

Schauster³

et al. 1981

The Journal of Experimental Medicine

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One approach to investigating the nature of T lymphocyte recognition of exogenous antigens and mechanisms of Ir gene control has used small, well-defined peptide antigens. In previous studies we used synthetic homologues and analogues of human fibrinopeptide B to examine strain 2 and strain 13 guinea pig T cell responses and found that Ir gene control correlated with the presence or absence of the carboxyl terminal residue, and that responsiveness was determined by macrophage Ia antigens (1, 2). In addition, several peptide residues were identified that were responsible for the specificity of the T cell responses, and most likely served as contact residues for clonally distributed T cell antigen-combining receptors (3). However, these immune responses were solely cell mediated, and we were unable to generate detectable antibody by a variety of approaches. It was therefore difficult to compare T and B cell recognition of the same peptide antigen to determine whether the antigencombining repertoire of both cell types was similar. For this reason, we have employed the octapeptide hormone angiotensin II (AII) 1 as an antigen system to investigate T and B cell recognition. AII has been used previously to investigate the specificity and spatial constraints of antibody binding in several species (reviewed in reference 4). Moreover, Dietrich (5) found that free AII elicited both immediate and delayed-type hypersensitivity reactions in guinea pigs. In this study we have extended the findings of Dietrich to examine Ir gene control and the specificity of T cell responses to a variety of synthetic homologues and analogues of AII in strain 2 and strain 13 guinea pigs. Evidence is presented that demonstrates the exquisite specificity of Ir gene control of T cell responses and indicates that the diversity of the antigen recognition repertoire in strain 2 and strain 13 animals is generally nonoverlapping.

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“…In vitro, antibodies to renin (HAAS et aI., 1965), to extrarenal isorenins (MrCHE-LAKIS et aI., 1974), to angiotensinogen (EGGENA et aI., 1976), and to angiotensin have been used to characterize, inhibit, or meaSlU'e the respective antigens (for review see BOYD and PEART, 1974;FREEDLENDER et aI., 1974;V ALLOTON, 1974).…”

Section: B Immunological Interferencesmentioning

confidence: 99%

Interferences with the Renin-Angiotensin System and Their Effects on High Blood Pressure

Ganten¹,

Gross²

1977

Antihypertensive Agents

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Immunogenicity and Antigenicity of Angiotensin I and II

Cited by 7 publications

References 62 publications

Evidence for the existence of a family of biologically active angiotensin I-like peptides in the dog central nervous system.

Evidence for the existence of a family of biologically active angiotensin I-like peptides in the dog central nervous system.

Fine specificity of genetic regulation of guinea pig T lymphocyte responses to angiotensin II and related peptides

Interferences with the Renin-Angiotensin System and Their Effects on High Blood Pressure

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