Immunogenicity and efficacy of three recombinant subunit Pasteurella multocida toxin vaccines against progressive atrophic rhinitis in pigs

Liao, Chih-Ming; Huang, Chi‐Hsiang; Hsuan, Shih-Ling; Chen, Zeng-Weng; Lee, Wei‐Cheng; Liu, Cheng-I; Winton, James R.; Chien, Maw-Sheng

doi:10.1016/j.vaccine.2005.07.079

Cited by 25 publications

(21 citation statements)

References 31 publications

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“…Vaccinated piglets, originating from vaccinated and non-vaccinated sows had about 10% higher daily gain, reducing the feeding duration for 10 days as determined in their studies by Liao et al [5] . In vaccinated piglets there were almost half the deaths than in non-vaccinated pigs [8] .…”

Section: Discussionmentioning

confidence: 81%

“…Infections of pigs with P. multocida and B. bronchiseptica can also result in bronchopneumonia [3,4] . Moreover, AR causes significant global economic loss in swine production due to growth retardation [5] . [5] .…”

Section: Importance Of Vaccination Against Atrophic Rhinitis In Pigs mentioning

confidence: 99%

“…Moreover, AR causes significant global economic loss in swine production due to growth retardation [5] . [5] . Researchers have also evaluated the efficacy of AR vaccines in improving the growth rate of pigs, eliminating infection by toxigenic P. multocida and B. bronchiseptica from a farm, and inducing immune responses in sows and piglets to these bacteria [6,7] .…”

Section: Importance Of Vaccination Against Atrophic Rhinitis In Pigs mentioning

confidence: 99%

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Importance of Vaccination Against Atrophic Rhinitis in Pigs on Average Daily Gain and Mortality Rate

Stojanac¹,

Gagrčin²,

Stevančević³

et al. 2013

Kafkas Univ Vet Fak Derg

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The aim of this study was to investigate the effect of pigs, sows and piglets vaccination against atrophic rhinitis (AR) on the production results, the average daily gain (ADG) and mortality rate. Unvaccinated piglets, originating from vaccinated sows had a slightly higher ADG and only slightly less mortality than the control piglets (unvaccinated piglets and their mothers). Vaccinated piglets had a significantly higher (P<0.01) ADG and almost twice lower mortality rate than piglets unvaccinated, whether originating from vaccinated or unvaccinated mothers. Based on the observed results it is concluded that vaccination of pigs against AR significantly increases ADG and reduces mortality, and vaccination of sows against AR only slightly improves production performance and it is not economically justified for the studied farm. Keywords: Atrophic rhinitis, Vaccination, Average daily gain, Mortality rate, Pig Domuzlarda Atropik Rinite Karşı Aşılamanın Ortalama Günlük Kazanç ve Mortalite Oranı Üzerindeki Önemi ÖzetBu araştırmanın amacı, domuzların, dişi domuzların ve domuz yavrularının atropik rinite (AR) karşı aşılamalarının üretim sonuçları, günlük kazanç oranı (ADG) ve mortalite oranı üzerine etkisini araştırmaktır. Aşılanmış domuz, yavruları aşılanmış ya da aşılanmamış annelerden olup olmadığına bakılmaksızın aşılanmamış yavrulara göre yüksek ADG (P<0.01) ve neredyse iki kat düşük mortalite oranı gösterdiler. Bu sonuçlara dayanarak, domuzlarda AR'e karşı aşılamanın önemli derecede ADG'nı arttırdığı ve mortaliteyi düşürdüğü, ve dişi domuzların AR'e karşı aşılanmasının sadece az miktarda üretim performansını arttırdığı ve bunun çalışılan çiftliklerde ekonomik olarak anlamlı olmadığı sonucuna varılmıştır.

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Section: Discussionmentioning

confidence: 81%

Section: Importance Of Vaccination Against Atrophic Rhinitis In Pigs mentioning

confidence: 99%

Section: Importance Of Vaccination Against Atrophic Rhinitis In Pigs mentioning

confidence: 99%

See 1 more Smart Citation

Importance of Vaccination Against Atrophic Rhinitis in Pigs on Average Daily Gain and Mortality Rate

Stojanac¹,

Gagrčin²,

Stevančević³

et al. 2013

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown that vaccines contained PMT protein or PMT protein fragments are effective against AR [5][6][7][8][9]12]. In this study, an experimental AR vaccine was developed by replacing the extracted PMT components in commercial vaccines with recombinant Nterminal and C-terminal fragment of PMT expressed in E.coli.…”

Section: Discussionmentioning

confidence: 99%

“…Authentic PMT or recombinant PMT or analogues thereof have good immunological effects [3][4][5][6][7][8]. It has been reported that high levels of antibodies can be produced by inoculating sows with a mixture of three recombinant PMT fragments with/without Pasteurella multocida and the antibodies could be transmitted to their offspring with good protection against PMT challenge [9]. However, there was no report on the evaluation of experimental AR vaccine in which contains inactivated Bb and PMT recombinant fragments.…”

Section: Introductionmentioning

confidence: 99%