Immunogenicity and safety of a trivalent inactivated 2010–2011 influenza vaccine in Taiwan infants aged 6–12 months

Hwang, Kao-Pin; Hsu, Yu-Lung; Hsieh, Tsung-Hsueh; Lin, Hsiao-Chuan; Yen, Ting‐Yu; Wei, Hsiu-Mei; Lin, Hung‐Chih; Chen, An-Chyi; Chow, Julie Chi; Huang, Li‐Min

doi:10.1016/j.vaccine.2014.02.078

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…[ 18 ] In contrast, in the present study using the current standard dosage, we re-confirmed the lower response in younger children when prior vaccination status was not taken into consideration, which is consistent with the results of previous studies involving the current dosage. [ 3 , 4 ] Therefore, the low response at younger ages may be partly due to age rather than the lower dosage.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 ] However, few other studies have assessed age-specific immunogenicity. [ 4 , 5 ] Little is known about the effect of prior vaccinations on immunogenicity in children aged ≤ 3 years, although a number of studies have addressed the effects of prior vaccinations on immunogenicity in older children or adults and reported that prior vaccinations reduced the immune responses to IIV. [ 6 – 9 ]…”

Section: Introductionmentioning

confidence: 99%

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Prior vaccinations improve immunogenicity of inactivated influenza vaccine in young children aged 6 months to 3 years

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prior vaccinations improve immunogenicity of inactivated influenza vaccine in young children aged 6 months to 3 years

et al. 2018

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“…Our results did not include pre- and post-vaccination data, thus it may be difficult to discriminate whether antibody titers against influenza B were low even immediately after vaccination, or whether antibodies were fully produced but rapidly degraded. Previous studies have shown that immunity was lower against influenza B strains than against A strains 91014151617. Kang, et al9 reported that the seroprotection rates at 1 month, 6 months, and 12 months after vaccination against influenza B were 65.8%, 26.5% and 10.0%, respectively, in 6–35-month-old children.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Waning Immunity at 6 Months after Both Trivalent and Quadrivalent Influenza Vaccination in Korean Children Aged 6–35 Months

et al. 2019

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Background: The titer of influenza vaccine-induced antibodies declines over time, and younger children have lower immunogenicity and shorter duration of immunity. This study aimed to compare persistence of antibody at 6 months after influenza vaccination according to influenza virus strains, vaccine type, antigen dose, and primed status in children aged 6 to 35 months. Methods: A total 124 healthy children aged 6 to 35 months were enrolled from September to December 2016 at 10 hospitals in Korea and randomly assigned to either a full dose of quadrivalent influenza vaccine or a half dose of trivalent influenza vaccine with Victoria B strain group. Hemagglutination inhibition antibody titers (that measure the seroprotection rates) were assessed for the recommended influenza strains at 6 months post vaccination. Results: The seroprotection rates at 6 months for strains A (H1N1), A (H3N2), B/Yamagata, and B/Victoria were 88.7%, 97.4%, 36.6%, and 27.6%, respectively. The seroprotection rates for A (H1N1), A (H3N2) and B (Victoria) were 91.4%, 98.7% and 27.5% in a full dose of quadrivalent vaccine vs. 83.7%, 94.6% and 27.9% in a half dose trivalent vaccine, respectively. The seroprotection rate for the B (Yamagata) strain was 23.8% in the quadrivalent group and 14.0% in the trivalent group. Conclusion: Persistence of antibodies at 6 months was more favorable against the influenza A strains than against the B strains. Persistence of antibodies to additional B strain at 6 months was superior in the quadrivalent vaccine group. The immunity of primed children with different B strains was not superior to that of the unprimed group with another B strain.

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Acquired Peripheral Neuropathies

Smith¹

2017

Swaiman's Pediatric Neurology

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Immunogenicity and safety of a trivalent inactivated 2010–2011 influenza vaccine in Taiwan infants aged 6–12 months

Cited by 5 publications

References 19 publications

Prior vaccinations improve immunogenicity of inactivated influenza vaccine in young children aged 6 months to 3 years

Prior vaccinations improve immunogenicity of inactivated influenza vaccine in young children aged 6 months to 3 years

Evaluation of Waning Immunity at 6 Months after Both Trivalent and Quadrivalent Influenza Vaccination in Korean Children Aged 6–35 Months

Acquired Peripheral Neuropathies

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