Immunogenicity and safety of a 23-valent pneumococcal polysaccharide vaccine in healthy children and in children at increased risk of pneumococcal infection

Lee, Hoan-Jong; Kang, Jin Young; Henrichsen, Jørgen; Konradsen, Helle Bossen; Jang, Seong-Hee; Shin, Hee‐Young; Ahn, Hyo‐Won; Choi, Yong; Hessel, Luc; Nam, SungWoo

doi:10.1016/0264-410x(95)00093-g

Cited by 63 publications

(35 citation statements)

References 36 publications

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“…Children with house-dust mite (HDM) sensitization had lower pneumococcal surface protein A titers at three years of age as well as lower anti-P6 antibody for H. influenza 16 and lower pneumococcal antibody titers. 30,39 We recently reported that HDM-stimulated IL-5 secretion was inversely correlated with pneumococcal antibody values in asthmatics. 39 …”

Section: Discussionmentioning

confidence: 97%

Asthma Status and Waning of Measles Antibody Concentrations after Measles Immunization

Yoo¹,

Jacobson²,

Weaver

et al. 2014

Pediatric Infectious Disease Journal

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Background Asthmatics have increased risks of common and serious microbial infections including vaccine preventable diseases. Little is known about whether asthma influences waning of humoral immunity. We assessed whether asthma status influences waning of anti-measles virus antibody concentrations over time. Methods The study utilized a cross-sectional study cohort of healthy children who had been immunized with one-dose of MMR-II at age approximately 15 months. Between 5 and 12 years of age, measles vaccine virus-specific antibody (IgG) values were measured by EIA and considered seropositive if the EIA index unit was ≥ 1. The medical records were reviewed to determine asthma status during the first 18 years of life by applying predetermined criteria for asthma. A least squares regression model was used to evaluate the effect of asthma status on the relationship between measles antibody titer and time elapsed between the initial measles vaccination and measurement of measles antibody concentrations. Results Of the 838 eligible children, 281 (34%) met criteria for asthma. Measles antibody waned over time (r=-0.19, p<0.001), specifically more rapidly in asthmatics (r=-0.30, p<0.001, a decrease of -0.114 unit per year) than non-asthmatics (r=-0.13, p=0.002, a decrease of -0.046 unit per year) (p-value for interaction=0.010). This differential waning rate resulted in a lower mean (SD) measles antibody concentration [1.42 (0.67) vs. 1.67 (0.69), p=0.008] and lower seropositivity rate (73% vs. 84%, p=0.038) in asthmatics than non-asthmatics starting around 9.3 years after the initial measles vaccination. Conclusion Asthma status is associated with waning kinetics of measles antibody among children.

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Section: Discussionmentioning

confidence: 97%

Asthma Status and Waning of Measles Antibody Concentrations after Measles Immunization

Yoo¹,

Jacobson²,

Weaver

et al. 2014

Pediatric Infectious Disease Journal

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“…106 Another study compared serotype-specific pneumococcal antibody levels before and after vaccination with PPV23 between children with asthma and those without asthma aged 2-18 years. 78 Asthmatics had significantly lower antibody levels against the studied pneumococcal antigens both pre- and post-vaccination. Another study assessed antibody response to PPV23 in children with and without atopic dermatitis aged 3-8 years and found that 17% of children with atopic dermatitis responded to PPV23, compared to 57% of children without atopic dermatitis (OR:0.2, 95%CI: 0.05-0.84, P =.03).…”

Section: The Potential Mechanismsmentioning

confidence: 87%

What Does Tympanostomy Tube Placement in Children Teach Us About the Association Between Atopic Conditions and Otitis Media?

Juhn

2014

Curr Allergy Asthma Rep

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Otitis media is the most common infection second only to viral upper respiratory infection in the outpatient setting. Tympanostomy tube insertion (TTI) is the most common ambulatory surgical procedure in the United States. While many risk factors for otitis media have been identified, atopic conditions have been under-recognized as risk factors for recurrent and persistent otitis media. Given that asthma and other atopic conditions are the most common chronic conditions during childhood, it is worth examining the association between atopic conditions and risk of otitis media, which can provide insight into how atopic conditions influence the risk of microbial infections. This paper focuses its discussion on otitis media, however it is important that the association between atopic conditions and risk of otitis media be interpreted in the context of the association of atopic conditions with increased risks of various microbial infections.

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“…The mean age of the 23 There was one early recurrence, 1 month after surgery, as a consequence of undetected accessory spleens. These was found and removed laparoscopically with a good, lasting response.…”

Section: Itp Groupmentioning

confidence: 98%

“…(f) administration of pneumococcal vaccines at >1 week before operation [23]. Techniques for the collection of intraoperative blood loss were adopted for all patients.…”

Section: Surgical Techniquementioning

confidence: 99%

Laparoscopic splenectomy for hematological diseases

et al. 2002

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Immunogenicity and safety of a 23-valent pneumococcal polysaccharide vaccine in healthy children and in children at increased risk of pneumococcal infection

Cited by 63 publications

References 36 publications

Asthma Status and Waning of Measles Antibody Concentrations after Measles Immunization

Asthma Status and Waning of Measles Antibody Concentrations after Measles Immunization

What Does Tympanostomy Tube Placement in Children Teach Us About the Association Between Atopic Conditions and Otitis Media?

Laparoscopic splenectomy for hematological diseases

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