Immunogenicity evaluation of Gam-COVID-Vac (Sputnik V)

Kirillov, I. A.; Pirozhkov, A. P.; Rubtsov, V. V.; Loginova, S. Ya.; Saifulina, N. A.; Plekhanova, T. M.; Timofeev, M. A.; Kutaev, D. A.; Logunov, Denis Y.; Gintsburg, A. L.; Borisevich, S. V.

doi:10.30895/2221-996x-2022-22-4-435-445

Biological Products. Prevention, Diagnosis, Treatment

2022

DOI: 10.30895/2221-996x-2022-22-4-435-445

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Immunogenicity evaluation of Gam-COVID-Vac (Sputnik V)

I. A. Kirillov

A. P. Pirozhkov²,

V. V. Rubtsov³

et al.

Abstract: In November 2020, the Armed Forces of the Russian Federation began mass immunisation of the personnel with Gam-COVID-Vac (Sputnik V), the first Russia vaccine against the new coronavirus infection (COVID-19). Thus, it became necessary to assess post-vaccination antibody levels and the duration and intensity of humoral immunity to COVID-19.The aim of the study was to investigate the immunogenicity and efficacy of Gam-COVID-Vac in military medical staff after vaccination.Materials and methods: the authors determ… Show more

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Cited by 3 publications

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Immunological Efficacy of Vaccination against COVID-19 in Employees of Medical Institutions of Various Profiles: Psychiatric Hospital and Regional Hospital

Murzina,

Zubkov,

Svitich

et al. 2024

Epidemiology and Vaccinal Prevention

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Relevance. On the territory of the Russian Federation, mass vaccination of the population is recognized as a priority health strategy against COVID-19, Gam-COVID-Vac vaccine has been widely used. The main risk group, which is subject to priority vaccination, are employees of medical organizations (MO). The determination of IgG to SARS-CoV-2 is an important parameter for assessing the intensity and duration of post-vaccination immunityAims. Study the immunological efficacy of the vaccine Gam-COVID-Vac used by employees of a psychiatric hospital and a regional hospital.Materials and methods. A study of the blood sera of 410 employees of two MO of various profiles who received one full course of the Gam-COVID-Vac» vaccine for the presence of IgG to RBD Spike SARS-CoV-2 using a set of reagents «SARS-CoV-2-IgG quantitative-ELISA-BEST» and IgG to NC SARS-CoV-2 using a set of reagents «ELISA anti-SARS-CoV-2 IgG».Results and discussion. Specific IgG to RBD Spike SARS-CoV-2 after vaccination with «Gam-COVIDVac » were found in 92.9% of psychiatric hospital staff and 98.0% of the regional hospital. Antibodies of class G to SARS-CoV-2 with a level of 300 BAU/ml or more were detected in 11.6% of psychiatric hospital staff and in 70.0% of regional hospitals, which is associated with the smallest proportion of persons in a psychiatric hospital with hybrid immunity than in a regional hospital (67.4% vs. 89.0%, respectively). A study of employees of the Ministry of Defense of various profiles revealed a difference in the level of IgG to RBD Spike SARS-CoV-2: 178.0 BAU/ml in a psychiatric hospital and 366.0 BAU/ml in a regional hospital. In a psychiatric hospital, the IgG level was highest up to 3 months after the completed vaccination – 166.4 BAU/ml, in a regional hospital from 3 to 6 months – 362.8 BAU/ml, then the number of antibodies decreases, which indicates the importance of monitoring for class G antibodies to SARS-CoV-2 at different times after vaccinations. Among the employees of the two MO, mild forms of the COVID-19 disease prevailed.Conclusion. Thus, the high immunological effectiveness of vaccination against COVID-19 with Gam-COVID-Vac was established in a group of employees of two MO, and the need for serological monitoring for the purpose of revaccination was also shown.

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Immunological Efficacy of Vaccination against COVID-19 in Employees of Medical Institutions of Various Profiles: Psychiatric Hospital and Regional Hospital

Murzina,

Zubkov,

Svitich

et al. 2024

Epidemiology and Vaccinal Prevention

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show abstract

Evaluation of some parameters of the COVID-19 epidemic process and the epidemiological effectiveness of the use of the Gam-COVID–Vac vaccine among employees of two medical organizations in the Moscow region

Murzina,

Ayvazyan,

Kalnin

et al. 2023

Sanitary Doctor

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The article presents the features of the COVID-19 epidemic process for 2020–2022 and the results of the effectiveness of the «Gam-COVID-Vac» vaccine used in employees of two different medical organizations (MO). In both institutions, the dynamics of a decrease in the incidence of COVID-19 with asynchronous periods of growth and decline of varying intensity and duration has been established. It is noted that in the regional hospital, each epidemic period of growth and decline was more intense than in a psychiatric hospital. In the studied organizations, seasonal increases in morbidity were revealed, characteristic of infections with airborne transmission, as well as an increase in morbidity in other months associated with the appearance of new variants of the SARS-CoV-2 virus. The highest proportion of COVID-19 cases was among employees of the age group from 30 to 49 years and nursing staff. In the Ministry of Defense, asymptomatic and mild forms of the disease prevailed among those who had COVID-19 and accounted for 76.5 % in a psychiatric hospital and 67.3 % in a regional hospital. The proportion of severe forms of diseases was 2.1 times higher among employees of the regional hospital. According to the results of the survey, various places of infection of employees of the Ministry of Defense were identified. In the regional hospital, nosocomial infection prevailed, in the psychiatric hospital, employees were more often infected outside the institution. A decrease in the effectiveness index (IE) of the Gum-COVID-Vac vaccine was found both in a psychiatric hospital and in a regional hospital from 12.0 in 2021 to 3.3 in 2022 and from 12.8 to 4.5, respectively, and the efficiency coefficient (CE) from 91.7 to 69.4 % and from 92.2 up to 77.9 %, respectively. Correlation coefficient between the incidence of COVID-19 and vaccination of employees with the drug «Gam-COVID-Vac» in a psychiatric hospital for 2021–2022. it was minus 0.42 %, in the regional hospital — minus 0.24 %, which indicates a negative strength of the connection and a decrease in the effectiveness of vaccination, which requires a change in immunization tactics and the need to improve the vaccine.

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On the issue of the safety of domestic vaccines against new coronavirus infection in medical workers

Zhukova,

Mirskaya,

Gotvyanskaya

et al. 2024

Sanitary Doctor

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A necessary condition for combating the pandemic of the new coronavirus infection (COVID-19) was the mass immunization of the population. Since any immunobiological drug can lead to the development of adverse reactions of the human body, it is necessary to characterize adverse events in the post-vaccination period. The aim of the study was to assess the frequency of registration of post-vaccination reactions in medical personnel of multidisciplinary hospitals when using vaccines against COVID-19, approved for use in the Russian Federation. An anonymous questionnaire was developed, using which 2,989 medical workers from Moscow, Moscow, Tula, Vladimir, and Kaluga regions were interviewed between December 2021 and February 2022. It was found that the overwhelming majority of medical professionals rated the tolerability of vaccines against COVID-19 as good and satisfactory. No serious adverse effects of immunization have been identified. There were short-term post-vaccination reactions, manifested in an increase in body temperature, headache, general weakness, myalgia and arthralgia, as well as fever, pain, swelling, itching at the injection site. In more than 82 % of cases, the above reactions developed within the first three days after vaccination. When comparing the results of a retrospective one-stage cross-sectional online study (n = 6032) with the data we obtained, a comparable frequency of post-vaccination reactions was revealed. Thus, the study established good tolerability and low frequency of post-vaccination reactions during immunization against COVID-19.

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Immunogenicity evaluation of Gam-COVID-Vac (Sputnik V)

Cited by 3 publications

References 10 publications

Immunological Efficacy of Vaccination against COVID-19 in Employees of Medical Institutions of Various Profiles: Psychiatric Hospital and Regional Hospital

Immunological Efficacy of Vaccination against COVID-19 in Employees of Medical Institutions of Various Profiles: Psychiatric Hospital and Regional Hospital

Evaluation of some parameters of the COVID-19 epidemic process and the epidemiological effectiveness of the use of the Gam-COVID–Vac vaccine among employees of two medical organizations in the Moscow region

On the issue of the safety of domestic vaccines against new coronavirus infection in medical workers

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