2014
DOI: 10.4161/hv.28252
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Immunogenicity of influenza A(H1N1)pdm09 vaccine in patients with diabetes mellitus

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Cited by 21 publications
(22 citation statements)
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References 29 publications
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“…The role played by senescent T cells in T2D has been overlooked. This is surprising, as the immune impairments inherent to ageing also resemble those of chronic hyper glycaemia: poor control of infections and reduced vac cination responses together with elevated inflammatory activity [17,18]. We show here in a preliminary study that people living with T2D have an increased number of senescent T cells in both the CD4 + and CD8 + T cell compartments.…”
Section: Introductionmentioning
confidence: 73%
See 1 more Smart Citation
“…The role played by senescent T cells in T2D has been overlooked. This is surprising, as the immune impairments inherent to ageing also resemble those of chronic hyper glycaemia: poor control of infections and reduced vac cination responses together with elevated inflammatory activity [17,18]. We show here in a preliminary study that people living with T2D have an increased number of senescent T cells in both the CD4 + and CD8 + T cell compartments.…”
Section: Introductionmentioning
confidence: 73%
“…This is surprising, as the immune impairments inherent to ageing also resemble those of chronic hyper glycaemia: poor control of infections and reduced vac cination responses together with elevated inflammatory activity [17,18]. This is surprising, as the immune impairments inherent to ageing also resemble those of chronic hyper glycaemia: poor control of infections and reduced vac cination responses together with elevated inflammatory activity [17,18].…”
Section: Introductionmentioning
confidence: 99%
“…CD4 + and CD8 + T‐cell responses are known to be altered in DM, with hyperactivation of T cells being a major feature . Impaired glucose tolerance and diabetes are typically associated with poor control of infection, impaired vaccination responses, elevated inflammatory activity and shorter leucocyte telomere length . In addition, elevated HbA1c levels are associated with the accumulation of differentiated T cells in cytomegalovirus‐positive individuals .…”
Section: Discussionmentioning
confidence: 99%
“…Так, в одних работах сообщается, что более низкие титры антител у пациентов с СД2 связаны с высоким уровнем гликозилированного гемоглобина, пожилым возрастом, наличием Т-клеточного дефицита, поэтому требуется повторное введение вакцин [9]. Но чаще все-го исследования показывают, что у взрослых пациентов с СД антительный ответ на вакцинацию против грип-па не нарушен, особенно при использовании вакцин с адъювантами [10][11][12].…”
Section: оригинальная статьяunclassified