Immunogenicity of Routinely Used Childhood Vaccines When Coadministered With the 10-Valent Pneumococcal Non-typeable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV)

Knuf, Markus; Szenborn, Leszek; Moro, Masnuel; Petit, C.; Bermal, Nancy; Bernard, Laurence; Dieussaert, Ilse; Schuerman, Lode

doi:10.1097/inf.0b013e318199f61b

Cited by 85 publications

(54 citation statements)

References 29 publications

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“…Antibody concentrations against the diphtheria and tetanus antigens were higher when PHiD-CV was co-administered, presumably due to the diphtheria toxoid and tetanus toxoid carrier proteins used for serotypes 19F and 18C, respectively, in PHiD-CV. 35 This was shown in previous studies to result in an enhanced anti-PRP response when a tetanus-conjugate Hib vaccine was co-administered with PHiD-CV. 35 In our study, we also observed a trend for a higher anti-PRP antibody GMC in the PHiD-CV group compared to the HAV control group, although this difference did not reach statistical significance.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 88%

“…35 This was shown in previous studies to result in an enhanced anti-PRP response when a tetanus-conjugate Hib vaccine was co-administered with PHiD-CV. 35 In our study, we also observed a trend for a higher anti-PRP antibody GMC in the PHiD-CV group compared to the HAV control group, although this difference did not reach statistical significance.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 88%

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Safety and immunogenicity of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Chilean children

Lagos¹,

Muñoz²,

Levine³

et al. 2011

Human Vaccines

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Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 88%

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 88%

Safety and immunogenicity of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Chilean children

Lagos¹,

Muñoz²,

Levine³

et al. 2011

Human Vaccines

Self Cite

View full text Add to dashboard Cite

“…Finally, this study relied on measures of humoral immunity, which may less reliably predict disease risk than measures of cell-mediated immunity [36][37][38]. However, serologic evidence of immunity is the international standard by which vaccine immunogenicity is currently measured [37][38][39][40][41], and although seronegativity and disease susceptibility are not identical, loss of detectible antibody is associated with an increased risk of breakthrough disease [42].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Varicella seroepidemiology in United States air force recruits: A retrospective cohort study comparing immunogenicity of varicella vaccination and natural infection

Duncan

Witkop

Webber

et al. 2017

Vaccine

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seroepidemiology in United States air force recruits: A retrospective cohort study comparing immunogenicity of varicella vaccination and natural infection" (2017 a b s t r a c tBackground/Objectives: Infection with varicella zoster virus (VZV) produces lifelong immunity, but duration of post-vaccination immunity has not been established. The purpose of this study is to determine if a difference exists in the long-term seropositivity of anti-VZV antibodies in a cohort of young adults who were vaccinated against varicella as compared to a similar cohort with a history of chickenpox disease, and to determine which variables best predict waning seropositivity following varicella vaccination. Methods: This retrospective cohort study captures immunization and serology data from approximately 10,000 recruits who entered basic military training between January 1, 2008, and December 31, 2015, and who have childhood immunization records in the Air Force Aeromedical Services Information Management System. Varicella vaccine immunogenicity was determined relative to the immunogenicity of chickenpox disease, as measured by multiplex flow immunoassay. Among vaccine recipients, waning seroimmunity was modeled and adjusted for several important covariates. Results: Basic military trainees who received varicella vaccine in childhood were 24% less likely to be seropositive to VZV than trainees who were exempt from vaccine due to a history of chickenpox disease. There was no significant difference in seropositivity between male and female trainees. The odds of a vaccinated trainee being seropositive to VZV decreased by 8% with each year elapsed since vaccination. Seroprevalence declined below estimated herd immunity thresholds in vaccinated trainees born after 1994, and in the cohort as a whole for trainees born after 1995. Conclusion: Despite prior vaccination, seroimmunity in a large cohort of young adults unexposed to wildtype VZV failed to meet the estimated threshold for herd immunity. If vaccination in accordance with the current US VZV vaccination schedule is inadequate to maintain herd immunity, young adults not previously exposed to wild-type VZV may be at increased risk for varicella outbreaks.Published by Elsevier Ltd.

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“…The GMC of those vaccinated with PCV10 was 2.132 mg/mL (95% CI 1.925-2.362) compared to 1.176 mg/ mL (95% CI 0.973-1.423) in those vaccinated with PCV7, suggesting an enhancement of the anti-Hib response by the TT carrier used for serotype 18C in PCV10. 7 …”

Section: Carrier Specific Enhancement Of T-cell Helpmentioning

confidence: 99%

Interactions of conjugate vaccines and co-administered vaccines

Findlow

Borrow

2015

Human Vaccines & Immunotherapeutics

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Immunogenicity of Routinely Used Childhood Vaccines When Coadministered With the 10-Valent Pneumococcal Non-typeable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV)

Cited by 85 publications

References 29 publications

Safety and immunogenicity of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Chilean children

Safety and immunogenicity of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Chilean children

Varicella seroepidemiology in United States air force recruits: A retrospective cohort study comparing immunogenicity of varicella vaccination and natural infection

Interactions of conjugate vaccines and co-administered vaccines

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