Immunogenicity, protective efficacy and safety of a recombinant DNA vaccine encoding truncated<i>Plasmodium yoelii</i>sporozoite asparagine-rich protein 1 (PySAP1)

Zhao, Jia; Deng, Shijie; Liang, Jiayuan; Cao, Yaming; Liu, Jun; Du, Feng; Shang, Hong; Luo, Enjie

doi:10.4161/hv.23688

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…In targeted deletion studies, P. yoelii S"P1 knockout sporozoites can invade hepatocytes but arrest in early liver stage development [220]. The P. yoelii genome sequence encoding the S"P1 protein domain corresponding to amino acids 3063 3227, and lanked by two CpG motifs to enhance the immune response, was cloned into pcDN"3.1(+) [221]. S"P1encoded in plasmid DN" was evaluated for protective immunity against challenge with a homologous strain of P. yoelii.…”

Section: Dna Vaccine Encoding Sapmentioning

confidence: 99%

Pre-Erythrocytic Vaccine Candidates in Malaria

Tucker¹,

Noe²,

Kotraiah³

et al. 2016

Current Topics in Malaria

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Abstract" vaccine providing sterile immunity against malaria has been shown to be possible with antigens from the pre-erythrocytic stages of malaria. Therefore, it is reasonable to focus vaccine development eforts on the pre-erythrocytic stages, consisting of both sporozoites and liver stage parasites, where it is expected that sterile immunity against the parasite can be elicited to block the development of blood stage infection, clinical disease, and resulting parasite transmission. "ccordingly, we will review the preclinical and clinical studies of malaria pre-erythrocytic eforts as well as highlight the advances, trends, and roadblocks encountered in these eforts.

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Section: Dna Vaccine Encoding Sapmentioning

confidence: 99%

Pre-Erythrocytic Vaccine Candidates in Malaria

Tucker¹,

Noe²,

Kotraiah³

et al. 2016

Current Topics in Malaria

View full text Add to dashboard Cite

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Emerging therapeutic modalities against malaria

Chalapareddy

Sajid

Arora

et al. 2021

Translational Biotechnology

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Immunogenicity and immunizing protection effect of GAMA gene DNA vaccine on Plasmodium berghei

Wang

Zhao

et al. 2016

Asian Pacific Journal of Tropical Medicine

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GAMA has good antigenicity, which could stimulate the body to produce specific immune responses; while DNA vaccine immunity could not play a good protective effect, the effect of which is only limited to the slight reduction of liver worm load, and has no obvious erythrocyte-stage protective effect and transmission-blocking effect. Therefore, trying other immunization strategies for further research on the value of GAMA (as multi-stage antigen vaccine and multi-stage combined vaccine components of the life-cycle of plasmodium) is necessary.

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Immunogenicity, protective efficacy and safety of a recombinant DNA vaccine encoding truncatedPlasmodium yoeliisporozoite asparagine-rich protein 1 (PySAP1)

Cited by 4 publications

References 38 publications

Pre-Erythrocytic Vaccine Candidates in Malaria

Pre-Erythrocytic Vaccine Candidates in Malaria

Emerging therapeutic modalities against malaria

Immunogenicity and immunizing protection effect of GAMA gene DNA vaccine on Plasmodium berghei

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