Immunoglobulin A reaction to oral streptococci in saliva of subjects with different combinations of caries and levels of mutans streptococci

Bratthall, Douglas; Serinirach, Ratana; Hamberg, Kristina; Widerström, Lena

doi:10.1111/j.1399-302x.1997.tb00381.x

Cited by 36 publications

(41 citation statements)

References 27 publications

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“…1) were likely due to physiological maturation of the mucosal immune system. Studies in older children and adults revealed a tendency for higher intensity and more complex patterns of IgA reaction to S. mutans Ags among low-infected and/or low-caries-active subjects in comparison to caries-active ones (4,5). However, no specific pattern of IgA response was associated with susceptibility to infection.…”

Section: Discussionmentioning

confidence: 95%

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Characterization of Salivary Immunoglobulin A Responses in Children Heavily Exposed to the Oral Bacterium Streptococcus mutans : Influence of Specific Antigen Recognition in Infection

et al. 2005

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The initial infection of children by Streptococcus mutans, the main pathogen of dental caries, depends on the ability of S. mutans to adhere and accumulate on tooth surfaces. These processes involve the adhesin antigen I/II (AgI/II), glucosyltransferases (GTF) and glucan-binding protein B (GbpB), each a target for anticaries vaccines. The salivary immunoglobulin A (IgA) antibody responses to S. mutans antigens (Ags) were characterized in 21 pairs of 5-to 13-month-old children. Pairs were constructed with one early S. mutans-infected and one noninfected child matched by age, racial background, number of teeth, and salivary levels of IgA. Specific salivary IgA antibody response and S. mutans infection levels were then measured during a 1-year follow-up. Robust responses to S. mutans were detected from 6 months of age. Salivary IgA antibody to AgI/II and GTF was commonly detected in salivas of all 42 children. However, GbpB-specific IgA antibody was seldom detected in the subset of infected children (38.1% at baseline). In contrast, most of the subset of noninfected children (76.2%) showed GbpB-reactive IgA antibody during the same period. Frequencies of GbpB responses increased with age, but differences in intensities of GbpB-IgA antibody reactions were sustained between the subsets. At baseline, GbpB-reactive IgA antibody accounted for at least half of the total salivary IgA S. mutans-reactive antibody in 33.3 and 9.5% of noninfected and infected children, respectively. This study provides evidence that a robust natural response to S. mutans Ags can be achieved by 1 year of age and that IgA antibody specificities may be critical in modulating initial S. mutans infection.

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Section: Discussionmentioning

confidence: 95%

“…Previous studies have indicated a high diversity of patterns of salivary immunoglobulin A (IgA) response to S. mutans Ags in children and adults (4,5,31). However, there has been no consistent evidence that differences in patterns of salivary IgA specificities or intensity of response influence the susceptibility to S. mutans infection and caries development.…”

mentioning

confidence: 87%

Characterization of Salivary Immunoglobulin A Responses in Children Heavily Exposed to the Oral Bacterium Streptococcus mutans : Influence of Specific Antigen Recognition in Infection

et al. 2005

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“…Intranasally immunized mice received 1.5 ϫ 10 8 CFU suspended in 10 l of PBS in each nostril. Immunizations were done on days 1, 3,6,8,10,12,14,33,35,37, and 40. Saliva, vaginal wash, and serum samples were collected prior to immunization.…”

Section: Methodsmentioning

confidence: 99%

“…Few data are available regarding protective immunity directed against complex P1 epitopes; however, Kelly et al (32) did observe a significantly higher proliferative response of lymphocytes isolated from low-caries individuals against a particular T-cell epitope. Bratthall et al (10) also pointed out the complexity of the relationship between dental caries and immune specificity. Their results suggested that low-caries children mounted a more diverse salivary IgA response against sonicated antigens of S. mutans and S. sobrinus and reacted against determinants not recognized by high-caries children.…”

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confidence: 99%

Monoclonal Antibody-Mediated Modulation of the Humoral Immune Response against Mucosally AppliedStreptococcus mutans

et al. 2000

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Systemic immunization with antigen coupled to monoclonal antibody (MAb) has been used by several investigators to increase the number of MAb-producing hybridomas against an antigen and to elicit antibodies specific for poorly immunogenic epitopes. This strategy has implications for vaccine design in that protective immunity is not necessarily directed at immunodominant epitopes of pathogens and may be improved by deliberately shifting the immune response toward subdominant epitopes. To our knowledge, no studies to date have addressed the potential for immunomodulatory activity mediated by MAbs bound to mucosally applied antigen. To test whether administration of an exogenous MAb directed against a streptococcal surface protein could influence the humoral immune response, BALB/c mice were immunized orally by gastric intubation or intranasally with Streptococcus mutans alone or S. mutans complexed with a MAb directed against the major surface protein P1. Significant changes in the subclass distribution, as well as the specificity, of anti-P1 serum immunoglobulin G antibodies were demonstrated in groups of mice which received S. mutans coated with the anti-P1 MAb versus those which received S. mutans alone. Alterations in the humoral immune response were dependent on the amount of anti-P1 MAb used to coat the bacteria. In addition, differences in the anti-P1 immune responses were observed between groups of mice immunized via oral versus intranasal routes. In summary, an exogenous MAb complexed with a streptococcal antigen prior to mucosal immunization can influence the immunoglobulin isotype and specificity of the host humoral immune response against the antigen.

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“…[11][12][13] In addition, many studies demonstrated that high salivary sIgA levels result in lower incidence of dental caries. [14][15][16] With the increasing use of fluoride products, dental fluorosis has become more common. Dental fluorosis is characterized by enamel hypomineralisation with increased surface and subsurface porosity, which causes opacity, pitting, or staining of the enamel.…”

mentioning

confidence: 99%

Effect of fluoride on salivary immunoglobulins and sialic acid

Güzel

Kırzıoğlu

Adiloğlu

et al. 2017

Rev. Assoc. Med. Bras.

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Immunoglobulin A reaction to oral streptococci in saliva of subjects with different combinations of caries and levels of mutans streptococci

Cited by 36 publications

References 27 publications

Characterization of Salivary Immunoglobulin A Responses in Children Heavily Exposed to the Oral Bacterium Streptococcus mutans : Influence of Specific Antigen Recognition in Infection

Characterization of Salivary Immunoglobulin A Responses in Children Heavily Exposed to the Oral Bacterium Streptococcus mutans : Influence of Specific Antigen Recognition in Infection

Monoclonal Antibody-Mediated Modulation of the Humoral Immune Response against Mucosally AppliedStreptococcus mutans

Effect of fluoride on salivary immunoglobulins and sialic acid

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