Immunoglobulin concentrations in human tears in ocular diseases.

Dk, Sen; Sarin, G. S.

doi:10.1136/bjo.63.5.297

Cited by 43 publications

(29 citation statements)

References 15 publications

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“…Our data show a sharp increase in IgG during inflammation, in contrast to a recent report by Sen & Satin (1979), who found measurable levels of IgG only in the tears from one out of ten cases of conjunctivitis vernalis. These differences are probably not explainable only by the differences in sampling techniques, without stimulation in our study and after exposition to a strong slit lamp by Sen and Satin (1979).…”

Section: Discussioncontrasting

confidence: 55%

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Proteins in tears from healthy and diseased eyes

Zavaro¹,

Samra²,

Baryishak³

et al. 1980

Doc Ophthalmol

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The levels of total protein in tears from healthy donors, conjunctivitis vernalis patients, and conjunctivitis follicularis patients, were 625, 1370 and 1160 mg% respectively. Serum albumin accounted for 3.3%, 43% and 67% of the total protein of tears from these groups, and the level of proteins probably synthesized by the lacrimal gland, was in tears from conjunctivitis follicularis patients only half the level in normal tears. By crossed immunoelectrophoresis with intermediate gel, 10 antigenic species could be recognized in normal tears, and of these the following were identified: Lysozyme, IgA, lactoferrin and serum albumin. In tears from patients with conjunctivitis vernalis three more immunoprecipitates were observed, of which one was due to IgG. No lysozyme could be demonstrated in tears from a case of conjunctivitis sicca by immunoelectrophoresis. In tears from healthy donors the mean level of IgA was 20 mg%, of IgG 3 mg%, and IgM could not be demonstrated. Rabbit anti-tear immunoglobulin did not precipitate a standard of human IgM in double immunodiffusion. In cases of conjunctivitis vernalis and follicularis the mean levels were increased to 80 and 114 mg% IgG, and 11 and 14 mg% IgM, but IgA was increased only to 32 and 41 mg%. It is assumed that the level of IgA in normal tears is almost entirely due to local synthesis, while serum albumin and other immunoglobulins may have escaped from the circulation by molecular sieving. The increased levels of immunoglobulins in inflammatory diseases is probably due to transudation. However, in blepharoconjunctivitis patients several tear samples with a high IgM and a low or zero level of IgG could be demonstrated. Possible explanations for this phenomenon are discussed.

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Section: Discussioncontrasting

confidence: 55%

“…These differences are probably not explainable only by the differences in sampling techniques, without stimulation in our study and after exposition to a strong slit lamp by Sen and Satin (1979).…”

Section: Discussionmentioning

confidence: 79%

Proteins in tears from healthy and diseased eyes

Zavaro¹,

Samra²,

Baryishak³

et al. 1980

Doc Ophthalmol

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“…Although the IgG Fc domain of rabbit IgG binds to the HSV-1 Fc␥R, the best-defined HSV-1 rabbit model is HSV-1 keratitis (6). This model is not optimal for evaluating the function of the HSV-1 Fc␥R, since the cornea is an avascular structure and low titers of IgG are present in tears (50).…”

mentioning

confidence: 99%

The Herpes Simplex Virus 1 IgG Fc Receptor Blocks Antibody-Mediated Complement Activation and Antibody-Dependent Cellular CytotoxicityIn Vivo

Lubinski

Lazear

Awasthi

et al. 2011

J Virol

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“…Later works [ 1,20], however, mention some com munication between the different secretory IgA regions: one presumes that that secretory IgA cells or some sort of messenger cells have the capacity to elicit IgA production in differ ent remote places: oral administration of antigen induced IgA antibody production in the mammary secretions, saliva and tears [20], The published reports are also conflict ing, concerning different eye disease and the following secretory IgA response. Some au thors [23,24] consider that the IgA level is predominantly increased in ocular diseases like corneal graft reaction and bacterial con junctivitis, whereas others [3,13] hold the opposite opinion, i. e. in any diseased eye acute graft reaction and dentritic keratitis, the IgA does not show any significant alter ations and as they say: 'The concentration of IgA in tears remained remarkably constant despite the presence or absence of diseases.' …”

Section: Commentsmentioning

confidence: 99%

Tear Protein Analyses in 30 Patients before and after Penetrating Keratoplasty

Lundh

Engler²

1989

Ophthalmologica

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The precise study of tears can afford good help in the preoperative and postoperative management of keratoplasties. Such studies may be performed with a laser nephelometer, a very comfortable and practical equipment for quantitative protein analysis, which enables one to analyze tears much more precisely than the break-up time and the Schirmer tests. Raised albumin and IgG values were demonstrated, indicating increased permeability of the blood-tear barrier, in the group with postoperatively reduced visual acuity, and lower values in the group with unchanged or increased visual acuity. Unfortunately, no statistically significant exclusive common laboratory findings for clinical signs of slight or severe rejection were found.

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Immunoglobulin concentrations in human tears in ocular diseases.

Cited by 43 publications

References 15 publications

Proteins in tears from healthy and diseased eyes

Proteins in tears from healthy and diseased eyes

The Herpes Simplex Virus 1 IgG Fc Receptor Blocks Antibody-Mediated Complement Activation and Antibody-Dependent Cellular CytotoxicityIn Vivo

Tear Protein Analyses in 30 Patients before and after Penetrating Keratoplasty

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