Immunoglobulin concentrations in nasal secretions differ between patients with an IgE-mediated rhinopathy and a non-IgE-mediated rhinopathy

Swart, Siebe; Baan, S. Van Der; Steenbergen, Joke J. E.; Nauta, J. J. P.; Kamp, Gerard J. van; Biewenga, Jeike

doi:10.1016/0091-6749(91)90155-h

Cited by 9 publications

(5 citation statements)

References 13 publications

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“…We adjusted ECP concentrations in nasal secretions to the albumin concentration by analogy with other studies on specific substances in nasal secretions in infants, although these studies used total protein concentration instead (8,9). It is possible, however, that in the case of nasal hypersecretion, lower protein concentrations would be expected at higher sample weights (23). It might also be possible that a high ECP concentration increases vascular permeability and thus increases the albumin content of the secretion.…”

Section: Discussionmentioning

confidence: 99%

Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy

1994

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Eosinophil cationic protein (ECP) in nasal secretions was determined in 34 infants with respiratory syncytial virus (RSV) bronchiolitis during the acute infection stage and one and six months later. ECP in serum was determined in 19 of these children at the same time. Myeloperoxidase (MPO) was determined in the same 19 children at the acute infection stage and after one month. All children were followed prospectively for two years after the infection with regard to the development of bronchial obstructive symptoms. Asthma, defined as three or more episodes of bronchial obstruction verified by a physician, developed in 18% of children and less severe obstructive symptoms in 29%. A screening test for food IgE antibodies in serum was performed six months and a skin prick test two years after the acute infection. Nasal ECP/albumin ratios after six months were significantly higher than during the acute RSV infection. MPO, but not ECP, levels in serum were significantly elevated at the time of acute infection compared with levels after one month. Nasal ECP/albumin ratios at the acute infection were compared to a control group of 27 infants with non‐RSV upper respiratory tract infections and did not differ. It was not possible to predict, either from ECP/albumin ratios in nasal secretion or from ECP and MPO in serum, which children would develop asthma, other bronchial obstructive symptoms or positive IgE tests.

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Section: Discussionmentioning

confidence: 99%

Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy

1994

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“…Neben Wasser und Elektrolyten lassen sich in hoher Konzentration Immunglobuline [Ig]-G und -A nachweisen. Sekretorisches Ig-A (zu 80 % Ig-A1; u. a. gegen Coxsackie-Viren, Polio-Viren) ist obligatorischer Bestandteil und stellt bis zu 50 % des Gesamtproteingehalts im Nasensekret [45] . Es wird von Plasmazellen nahe der basolateralen Membran der Dr ü senzelle in das Gewebe freigesetzt, bindet und neutralisiert das Antigen.…”

Section: Mukozili ä Re Clearance (Mcc)unclassified

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Beule¹

2010

Laryngo-Rhino-Otol

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In this review, anatomy and physiology of the respiratory mucosa of nose and paranasal sinuses are summarized under the aspect of its clinical significance. Basics of endonasal cleaning including mucociliary clearance and nasal reflexes, as well as defence mechanisms are explained. Physiological wound healing, aspects of endonasal topical medical therapy and typical diagnostic procedures to evaluate the respiratory functions are presented. Finally, the pathophysiologies of different subtypes of non-allergic rhinitis are outlined together with treatment recommendations.

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“…It serves as a mobile carrier for entrapped pathogens, particulate matter, and dissolved substrates and is moved by the ciliary beating at an average velocity of 2–25 mm per minute [ 67 ]. At the same time, it hosts and mediates the defense action of immunoglobulins (IgA and IgG) [ 68 , 69 ], immune cells (neutrophils, monocytes, macrophages), nitric oxide (NO), enzymes (lysozyme), proteins (lactoferrin), and the protective microflora—all produced and/or present in the nasal mucosa and responsible for its specific or nonspecific immune response [ 58 ]. The liquid milieu of the mucus is provided predominantly by the exocrine seromucous glands and, to a lesser extent, by the plasma transudation and the tear fluid [ 58 , 61 ].…”

Section: The Upper Respiratory Tract (Urt)mentioning

confidence: 99%

Advances in the Prophylaxis of Respiratory Infections by the Nasal and the Oromucosal Route: Relevance to the Fight with the SARS-CoV-2 Pandemic

et al. 2022

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In this time of COVID-19 pandemic, the strategies for prevention of the infection are a primary concern. Looking more globally on the subject and acknowledging the high degree of misuse of protective face masks from the population, we focused this review on alternative pharmaceutical developments eligible for self-defense against respiratory infections. In particular, the attention herein is directed to the nasal and oromucosal formulations intended to boost the local immunity, neutralize or mechanically “trap” the pathogens at the site of entry (nose or mouth). The current work presents a critical review of the contemporary methods of immune- and chemoprophylaxis and their suitability and applicability in topical mucosal dosage forms for SARS-CoV-2 prophylaxis.

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Immunoglobulin concentrations in nasal secretions differ between patients with an IgE-mediated rhinopathy and a non-IgE-mediated rhinopathy

Cited by 9 publications

References 13 publications

Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy

Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Advances in the Prophylaxis of Respiratory Infections by the Nasal and the Oromucosal Route: Relevance to the Fight with the SARS-CoV-2 Pandemic

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