Immunoglobulin constant heavy G chain genes as risk factors in childhood allergies

Oxelius, Vivi‐Anne; Bråbäck, Lennart; Ahlstedt, S.; Björkstén, Bengt

doi:10.1111/j.1365-2222.2006.02602.x

Cited by 11 publications

(14 citation statements)

References 25 publications

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“…The G1m (f) allele is only found in Caucasians, whereas the G1m (f,a) allele is common in Asians; other variants have also been described [9,66,67]. Plasma IgG concentrations are correlated with Gm allotypes [68,69] and IgG allotypes can influence clinical manifestations of immunity [9,70].…”

Section: Discussionmentioning

confidence: 99%

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

Barton

Bertoli²,

Acton

2016

Cellular Immunology

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Section: Discussionmentioning

confidence: 99%

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

Barton

Bertoli²,

Acton

2016

Cellular Immunology

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“…The IGHG association is found in patients with clinical allergy and increased IgE levels, increased IgG4 levels, a family history of allergy, and in technicians exposed to laboratory animals developing laboratory animal allergy [5,6,21,22,23]. The alternative IGHG haplotypes have been found with different pathways of immune regulation in patients with asthma [23].…”

Section: Introductionmentioning

confidence: 99%

“…Several candidate genes have been found to be associated with the inflammatory response of IgE-mediated allergy [1,2,3,4], such as immunoglobulin constant heavy G chain (Fcγ) (GM) genes (IGHG) on chromosome 14q32.3, which were reported in several studies [5,6]. …”

Section: Introductionmentioning

confidence: 99%

From Genotypes of Immunoglobulin Constant Heavy G Chains (Fcγ) (GM) Genes <b><i>(IGHG)</i></b> to Phenotypes in Childhood Asthma

Oxelius

2012

Int Arch Allergy Immunol

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Background: IgE-mediated allergy is associated with immunoglobulin heavy constant G chain (Fcγ) (GM) genes (IGHG) on chromosome 14q32.3. Investigation of the alternative GM allotypes of γ3, γ1 and γ2 chains has disclosed new structural and functional IgG subclasses and B-cell variants, with possible effects on childhood asthma. Objective: To investigate different IGHG (GM) gene complexes in a childhood asthma population for allergy parameters. Methods:IGHG alleles and correlated allotypic (allelic) IgG subclass levels were analyzed with a sensitive indirect competitive ELISA in 10-year-old children with bronchial asthma. Individual IGHG diplotype-, genotype- and haplotype-related B cells were compared for allelic IgG subclass levels, IgE sensitization, IgE, IgA and IgM levels, and numbers of peripheral blood eosinophils and lymphocytes. Results: The group with homozygous IGHG*bfn/*bfn (B1/B1 cells) demonstrated low IgG1*f levels (p < 0.001) but increased IgG2*n levels (p < 0.001) together with increasd IgE and IGHG2*n gene dose-dependent IgE sensitization (atopic phenotype). The IGHG*bf–n/*bf–n (B2/B2 cells) demonstrated low IgG1*f (p < 0.05) and IgG2*–n (p < 0.001) and the IGHG*ga–n/*ga–n (B4/B4 cells) low IgG1*a (p < 0.001) and IgG2*–n (p < 0.02) together with low IgE sensitization (non-atopic phenotype). B*^bfn (B1) and B*^bf–n (B2) demonstrated increased numbers of peripheral blood eosinophils, compared to B*^gan (B4) cells, which demonstrated increased peripheral blood CD8 lymphocytes instead. Conclusion:IGHG diplotypes present different phenotypes in childhood asthma. The IGHG2*n dose relationship to IgE sensitization and increased IgG2*n levels in IgE sensitized are risk markers for IgE-mediated asthma. The opposite IGHG2*–n presents non-IgE-mediated asthma and IgG subclass deficiencies.

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“…There is no genetic marker for IgE but IgG genes are informative. IGHG (Fc) (GM) genes are associated with allergen IgE sensitization [8,9,10,11,12,13,14]. Genome-wide association studies have not included GM genes in their genotyping platform [15,16,17] and have missed IGHG as candidate gene.…”

Section: Introductionmentioning

confidence: 99%

“…Allergens, bacteria [22,23] and virus [25,26,27] affect IGHG genes of individuals differently and relate to the diseases as allergy [7,8,9,10,11,12], primary immunodeficiency [28], autoimmunity [29,30] and malignancy [31,32]. …”

Section: Introductionmentioning

confidence: 99%

Innate IgG Molecules and Innate B Cells Expressed by Immunoglobulin Constant Heavy G Chain (Fcγ) Genetic Marker Genes Are Involved in the ‘Allergic March' of IgE Sensitization in Children

Oxelius

Krueger²,

Ahlstedt³

et al. 2015

Int Arch Allergy Immunol

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Background: Interindividual variations of immunoglobulin constant heavy G chain (IGHG) genes on chromosome 14q32.3 are identified by alternative genetic markers (GM) of IgG3, IgG1 and IgG2, respectively. They express structurally and functionally innate IgG molecules and B cells, associated with allergic disease, replicated in several studies. Materials and Methods: 1-year-old and 10-year-old, IgE-sensitized and non-sensitized children from the German Multicenter Allergy Study birth cohort were assessed by new serological methods for the mendelian IGHG (Fcγ) (GM) genes, as innate IgG molecules and innate B cells. Results: Food allergy sensitization in thirty-five 1-year-old children (124 not sensitized) was associated with the IGHG*bfn haplotype and B*^bfn cells (OR 1.9, 95% CI 1.2-3.1; p = 0.010). Aeroallergen sensitization in ninety-nine 10-year-old children (95 not sensitized) was associated with the same genes (OR 1.4, 95% CI 1.02-1.9; p = 0.034). The IgE sensitization was most prominent in the restrictive homozygous IGHG*bfn/*bfn diplotype, 34% at age 1, increasing to 60% at age 10, rating the highest numbers of positive IgE tests, expressing increased levels of IgE and innate IgG2*n. Conclusions: The IGHG*bfn haplotype (B*^bfn cells) and increased innate IgG2*n levels are predictive factors for IgE sensitization in childhood. IGHG genes can be assessed for prognostic and preventive purposes in clinical care.

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Immunoglobulin constant heavy G chain genes as risk factors in childhood allergies

Abstract: Background Several candidate genes have been found associated to the

Cited by 11 publications

References 25 publications

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

From Genotypes of Immunoglobulin Constant Heavy G Chains (Fcγ) (GM) Genes <b><i>(IGHG)</i></b> to Phenotypes in Childhood Asthma

Innate IgG Molecules and Innate B Cells Expressed by Immunoglobulin Constant Heavy G Chain (Fcγ) Genetic Marker Genes Are Involved in the ‘Allergic March' of IgE Sensitization in Children

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Immunoglobulin constant heavy G chain genes as risk factors in childhood allergies

Abstract: Background Several candidate genes have been found associated to the

Cited by 11 publications

References 25 publications

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

From Genotypes of Immunoglobulin Constant Heavy G Chains (Fcγ) (GM) Genes <b><i>(IGHG)</i></b> to Phenotypes in Childhood Asthma

Innate IgG Molecules and Innate B Cells Expressed by Immunoglobulin Constant Heavy G Chain (Fc&#947;) Genetic Marker Genes Are Involved in the ‘Allergic March' of IgE Sensitization in Children

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Innate IgG Molecules and Innate B Cells Expressed by Immunoglobulin Constant Heavy G Chain (Fcγ) Genetic Marker Genes Are Involved in the ‘Allergic March' of IgE Sensitization in Children