Immunoglobulin-containing Cells in Normal Jejunal Mucosa and in Ulcerative Colitis and Regional Enteritis

Söltoft, J.

doi:10.3109/00365526909180616

Cited by 34 publications

(10 citation statements)

References 7 publications

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“…This study has shown that these cells are primarily IgA-forming cells; fewer IgM and IgG immunocytes are present. The pre dominance of IgA immunocytes in the stomach, as was shown also by C rabbe and H eremans [5], is similar to that in the small and large intestine [4,8,[10][11][12] and vermiform appendix [2]. Thus, IgA-containing cells evi dently predominate over other Ig-containing cells along the entire lenghth of the gut.…”

Section: Discussionsupporting

confidence: 49%

Cellular Sites of Immunoglobulins

Chen¹,

Tobe²

1974

Digestion

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The distribution of immunoglobulin (Ig)- containing cells in the gastric antral mucosa of patients with various abnormalities of the stomach was studied by fluorescent antibody techniques. IgA-containing cells comprised about 80% of all Ig-containing cells and were diffusely distributed in the interstitial spaces of gastric glands. IgA was observed in the apical portion of the cytoplasm of cells in some pyloric glands, and IgM was seen extracellularly between the epithelial cells and in the lumen. At the base of gastric cancers, adjacent to the invading cancer mass, IgG-containing immunocytes were found in intermuscular spaces, and some cells that appeared to be cancer cells reacted with anti-IgG or anti-IgM.

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Section: Discussionsupporting

confidence: 49%

Cellular Sites of Immunoglobulins

Chen¹,

Tobe²

1974

Digestion

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“…In unaffected small bowel mucosa, IgA containing plasma cells predominate and the ratio of IgA: IgM: IgG plasma cells is similar to that observed in normal mucosa (Soltoff, 1969;Green and Fox, 1975). However, the mucosa in areas of bowel involved by Crohn's disease is characterized by a marked reduction in IgA containing plasma cells (Persson and Danielsson, 1973;Green and Fox, 1975).…”

Section: Discussionmentioning

confidence: 66%

Peripheral blood and intestinal lymphocyte sub-populations in Crohn's disease.

Strickland¹,

Husby²,

Black³

et al. 1975

Gut

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SUMMARY Immunofluorescent techniques were utilized to study the nature and distribution of cells forming the inflammatory infiltrate in Crohn's disease. Tissue from resected ileum (one patient) or colon (one patient) when compared with corresponding control tissues contained increased numbers of B and T lymphocytes. B-cells of IgG class predominated in the mucosal lamina propria, whereas T-cells were prominent in the deeper layers of inflamed bowel. Inflammatory cells bearing Fc receptors were also present in these tissues. Decreased peripheral blood T-cell numbers returned to normal after resection of the involved bowel in the two patients studied. Impaired cellular immunity in Crohn's disease may thus result from T-cell sequestration in or loss from involved segments of intestine.

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“…The distribution of immunoglobulin-containing cells in the mucosa of the gastrointestinal tract of normal persons is well established (Crabbe, Carbonara, and Heremans, 1965;Crabbe and Heremans, 1966), and the changes taking place in this system have been investigated from early infancy (Crabbe, 1967;Savilahti, 1972a). These cells have also been studied in various gastrointestinal diseases (Odgers and Wangel, 1968;Soltoft, 1969), especially in coeliac disease. Rubin, Fauci, Sleisenger, and Jefferies (1965) did not observe any difference between immunoglobulincontaining cells of adult coeliacs and controls.…”

mentioning

confidence: 99%

Intestinal immunoglobulins in children with coeliac disease

Savilahti¹

1972

Gut

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SUMMARY The numbers of immunoglobulin-containing cells in jejunal biopsy specimens of 19 children with active coeliac disease aged 05 to 16.5 years were studied by direct immunofluorescence. Intestinal juice immunoglobulins were measured in 14 of these patients.The number of IgA-containing cells was twice and the number of IgM-containing cells 2.5 times that of age-matched controls. There were also more IgG-, IgE-, and IgD-containing cells in the jejunal mucosa of the coeliac patients, but the absolute numbers of these cells were low. The immunoglobulin content of the intestinal juice was not altered in coeliacs.A follow-up biopsy specimen was available from seven patients kept on a strict gluten-free diet for one to four months. A significant fall in the numbers of immunoglobulin-containing cells was seen, and they did not differ at that time from the controls. Two patients were followed until full normalization of the jejunal structure and they had normal numbers of immunoglobulin-containing cells.In children with coeliac disease in contrast to adult coeliacs, the study shows that the IgA-producing system is quantitatively stimulated during gluten challenge. The rapid drop in the numbers of immunoglobulin-containing cells after gluten withdrawal suggests that there is no quantitative abnormality in the local immunoglobulin-producing system of the gut in coeliac disease.

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Immunoglobulin-containing Cells in Normal Jejunal Mucosa and in Ulcerative Colitis and Regional Enteritis

Cited by 34 publications

References 7 publications

Cellular Sites of Immunoglobulins

Cellular Sites of Immunoglobulins

Peripheral blood and intestinal lymphocyte sub-populations in Crohn's disease.

Intestinal immunoglobulins in children with coeliac disease

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