Immunoglobulin Heavy Chain Gene Rearrangement in Non B-cell Haematological Malignancies

Haslina, M N Noor; Marini, Rita; Rosnah, B; Shafini, M Y; Haslindawani, WM Wan; Nazri, H Mohd; Salamah, G; Jaafar, Hasnan; Hassan, Rosline

doi:10.7727/wimj.2013.253

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Second, tumor cells usually exhibit disruption of normal proliferation and differentiation. Hematopoietic stem cells in patients with hematological malignancies may only exhibit gene clonal rearrangement during the process of maturation to a specific lineage; however, these cells do not successfully differentiate into the specific cell lineage, resulting in functional disorders ( 22 ). Consequently, IGH and TCR monoclonal rearrangement may represent markers for the monitoring of some patients with AML, specifically those without recurrent genetic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia

et al. 2018

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The present study aimed to examine whether monoclonal immunoglobulin heavy chain (IGH) or T-cell receptor (TCR) gene rearrangement in cell-free DNA (cfDNA) may be used for minimal residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML). Monoclonal IGH and TCR rearrangement in cfDNA were monitored in patients with AML. A total of 94 (40%) patients had monoclonal IGH or TCR rearrangements in cfDNA at diagnosis; 84% of these patients (79 cases) achieved complete remission following 1–3 courses of induction chemotherapy. Among these cases, 89.9% were negative for monoclonal IGH or TCR rearrangement in cfDNA following consolidation chemotherapies. A total of 8 patients with consistently positive monoclonal IGH or TCR rearrangement in cfDNA relapsed within 6–10 months. During follow up, 39 patients demonstrated positive monoclonal IGH or TCR rearrangement in cfDNA and relapsed. Recurrence of monoclonal IGH or TCR rearrangement in cfDNA was observed 1–3 months earlier than bone marrow relapse and 11 patients with solitary extramedullary relapse demonstrated positive monoclonal IGH or TCR rearrangement recurrence in cfDNA. In conclusion, the detection of monoclonal IGH and TCR rearrangement in cfDNA may represent a useful tool for MRD monitoring in patients with AML.

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Section: Discussionmentioning

confidence: 99%

Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia

et al. 2018

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“…Immunoglobulin heavy chain gene (IGH) rearrangement is a genetic hallmark of B-cell origin and differentiation [1][2][3]. However, it has been demonstrated in previous reports that IGH rearrangements were also found in approximately 10-20% of patients with acute myeloid leukemia (AML) [4][5][6][7][8][9][10][11]. However, the clinical characteristics of AML with IGH rearrangements remain to be identified.…”

Section: Introductionmentioning

confidence: 99%

Diffuse Large B-Cell Lymphoma during Complete Remission of Acute Myeloid Leukemia (M4Eo) Exhibiting Immunoglobulin Heavy Chain Gene Rearrangement and Inv(16)

Kuriyama¹,

Hosoi²,

Masaya³

et al. 2019

Int J Blood Res Disord

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Background: In previous studies, it has been reported that 10-20% of acute myeloid leukemia (AML) cases showed immunoglobulin heavy chain gene (IGH) rearrangements, a genetic hallmark of B-cell differentiation. However, the clinical significance of this is uncertain. Here, we report a case of diffuse large B-cell lymphoma (DLBCL) after complete remission (CR) from AML that exhibited an IGH rearrangement. Case presentation: The patient was diagnosed with AML (M4Eo) with inversion of chromosome 16 [inv(16)]. Interestingly, the AML cells showed a monoallelic IGH rearrangement, as detected by the Southern blot analysis. The rearranged band was cloned using the inverse polymerase chain reaction (PCR) method. The sequence result revealed that a recombination between DH7-27 and JH4 occurred in the AML cells. PCR using DH7-27and JH4-specific primers yielded no band from DLBCL specimens, suggesting that the DLBCL did not occur owing to the AML cell with IGH rearrangement. In addition, fluorescent in situ hybridization (FISH) showed that inv(16) was not found in the DLBCL cells. Therefore, although the AML cells harbored an IGH rearrangement, the origins of the two tumors seemed to differ from each other. Conclusion: As the prognosis of AML became better, longterm follow-up studies of AML patients might define the clinical significance of IGH rearrangements in AML cells.

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“…O diagnóstico de proliferações malignas de células B é portanto, apoiado pelo achado de clonalidade do gene de Ig, enquanto que linfoproliferações reativas mostram genes de Ig com rearranjo policlonal (Cossman et al, 1991;Langerak et al, 2001). As cadeias pesada e leves de Ig apresentam rearranjo clonal em linfomas (baixo, intermediário e alto grau) e leucemias (Cossman et al, 1991;Aisenberg, 1993;Noor Haslina et al, 2013).…”

Section: Rearranjo Gênico Do Receptor De Ig E Tcrunclassified

Análise dos rearranjos gênicos de cadeias pesada e leves da imunoglobulina pela técnica de reação em cadeia da polimerase no auxílio diagnóstico de processos linfoproliferativos cutâneos de células B

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Sanches pela oportunidade, sabedoria e convívio ao longo dos anos. Que me permitiu amadurecimento como profissional dermatologista e como pessoa. Que me tocou na busca contínua de conhecimento e cuidado com os pacientes.Da mesma forma expresso meu sentimento de gratidão e admiração à minha coorientadora Professora Doutora Maria Claudia Nogueira Zerbini pela transferência de conhecimento, sensibilidade e convivência ao longo desses anos. Com certeza umas das pessoas mais sábias que conheci, que me tocou tanto por sua sabedoria e competência quanto pela humildade.Minha eterna gratidão à minha mãe, sempre me apoiando incondicionalmente nas minhas decisões. Que apesar de estar longe fisicamente; sempre esteve próxima no apoio, carinho, compreensão e palavras de ânimo nos vários momentos de dificuldades e fraqueza. Agradeço aos meus irmãos, grandes amigos e demais familiares, que sempre me apoiaram durante estes anos e compreenderam minhas ausências em prol dos meus projetos. Agradeço ao Halsted pelo companheirismo, carinho e apoio durante estes anos; seu auxílio foi muito valioso na construção desta tese ao longo dos anos.

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Immunoglobulin Heavy Chain Gene Rearrangement in Non B-cell Haematological Malignancies

Abstract: Immunoglobulin gene rearrangement, which occurs in almost all haematological malignancies of B-cell lineage, also presents in a very small proportion of T-cell or myeloid malignancies.

Cited by 4 publications

References 13 publications

Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia

Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia

Diffuse Large B-Cell Lymphoma during Complete Remission of Acute Myeloid Leukemia (M4Eo) Exhibiting Immunoglobulin Heavy Chain Gene Rearrangement and Inv(16)

Análise dos rearranjos gênicos de cadeias pesada e leves da imunoglobulina pela técnica de reação em cadeia da polimerase no auxílio diagnóstico de processos linfoproliferativos cutâneos de células B

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