Immunoglobulin production in vitro in major depression: A pilot study on the modulating action of endogenous cortisol

Kok, Frans W.; Heijnen, Cobi J.; Bruijn, Jan A.; Westenberg, H.G.M.; Ree, Jan M. van

doi:10.1016/0006-3223(94)00297-g

Cited by 11 publications

(4 citation statements)

References 45 publications

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“…In this study, AlCl 3 decreased IgG production, suggested that AlCl 3 inhibited humoral immune. Hydrocortisone, a kind of GCs, stimulated immunoglobulin production at concentration of 10 −8 mol/L and inhibited at concentration of 10 −5 mol/ L in peripheral blood lymphocytes from humans [46]. In this study, 10 −8 mol/L Cort stimulated IgG production and 10 −6 mol/L inhibited IgG production.…”

Section: Discussionsupporting

confidence: 50%

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Yang

Zhuang

et al. 2016

Biol Trace Elem Res

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Aluminum (Al) exposure is toxic to immune system. Studies have implicated that glucocorticoids (GCs) exert the dual regulation effect on the immune function depending on the concentration. However, it is unknown whether a dual effect of GCs exists in the AlCl3-treated lymphocytes. Corticosterone (Cort) is one kind of GCs. To investigate the effect of different concentration Cort on AlCl3-treated lymphocytes, rat splenic lymphocyte was isolated and cultured with 0.55 mmol/L AlCl3, simultaneously administrated Cort at final concentration of 0 (control group, CG), 10(-8) (low-level group, LG), and 10(-6) (high-level group, HG) mol/L, respectively. Another group without AlCl3 and Cort served as the blank group (BG). We found that low concentration Cort increased the T and B lymphocyte proliferation rate, proportions of CD4(+) T lymphocyte subset, IgG, IL-2, and TNF-α contents, whereas high concentration Cort decreased those in AlCl3-treated lymphocytes. In conclusion, the results of this study indicated that low concentration Cort relieves the immunotoxicity of AlCl3 on the splenic lymphocytes, whereas high concentration Cort aggravates it.

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Section: Discussionsupporting

confidence: 50%

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Yang

Zhuang

et al. 2016

Biol Trace Elem Res

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“…In fact, previous studies carried out in humans or laboratory animals under a large variety of experimental conditions have demonstrated that when adrenocortical activity is intense, T-cell activity is depressed and B-cell activity is elevated (MacMurray et al 1983;Kok et al 1995;Elenkov and Chrousos 1999;Moynihan 2003). In particular, Elenkov and Chrousos (1999) indicated that under stressful conditions, glucocorticoids may suppress cellular immunity and boost humoral immunity via an effect on T helper 1 (Th1)/Th2 cells and type 1/type 2 cytokine production.…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte functions in dairy cows in hot environment

et al. 2005

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This study was carried out to ascertain the effects of intense high environmental temperatures (HET) on lymphocyte functions in periparturient dairy cows. The study was undertaken from the beginning of March through the end of July 2003 in a commercial dairy unit located approximately 40 km north of Rome. Thirty-four Holstein cows were utilised in the study. Twenty-two of these cows gave birth in spring (SP cows), from 28 March to 30 April. The remaining 12 cows gave birth in summer (SU cows), between 15 June and 2 July. The two groups of cows were balanced for parity and were fed the same rations. Blood samples were taken 4, 3, 2 and 1 week before calving, and 1, 2 and 4 weeks after calving, in order to evaluate peripheral blood mononuclear cell (PBMC) function in vitro, and to determine plasma cortisol concentrations. After isolation, the PBMC were stimulated with mitogens and their response in terms of DNA synthesis and IgM secretion was measured. During spring, either the day (9-20 h) or the night (21-8 h) temperature humidity index (THI) was below the upper critical THI (72) established for dairy cows. During summer, the mean daily THI values were 79.5+/-2.9 during the day and 70.1+/-4.7 during the night. Furthermore, during summer, three heat waves (a period of at least 3 consecutive days during which there were less than 10 recovery hours) occurred. Recovery hours were intended hours with a THI below 72. The first heat wave lasted 5 days, the second 6 days, and the third 15 days. Compared to the SP cows, over the entire periparturient period the extent of DNA synthesis and IgM secretion levels were lower (P ranging from <0.01 to 0.0001) and higher (P<0.01) respectively, in the SU cows. Before calving, the SU cows also presented higher (P<0.01) concentrations of plasma cortisol compared to the SP cows. This study indicates that the effects of HET on the immune response depend on the specific immune function under consideration, and that neuroendocrinal changes due to HET may play a role in the perturbation of immune functions.

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“…This is more pronounced in elderly caregivers who are under chronic stress [25]. Furthermore, lymphocytes from persons under chronic depression (stress) become resistant to the immunosuppressive effect of steroids [26]. This was reported in depressive patients in whom chronically high cortisol levels are noticed [27].…”

Section: Psychoimmunology Of Nutritionmentioning

confidence: 94%

Psychoimmunology of Nutrition

Lesourd

2005

Home Care Enteral Feeding

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Immunoglobulin production in vitro in major depression: A pilot study on the modulating action of endogenous cortisol

Abstract: To investigate the possible differential sensitiviO' of hydrocortisone (HCO) on immunoglobulin (Ig) production in depression in

Cited by 11 publications

References 45 publications

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Lymphocyte functions in dairy cows in hot environment

Psychoimmunology of Nutrition

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