Immunoglobulin A and immunoglobulin G antibodies against β‐lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6

Abstract

Increased IgA or IgG against BLG or gliadin at age 1 was associated with IgE sensitization at age 6. We suggest that an enhanced antibody response to food antigens reflects mucosal tolerance aberrancies, e.g., altered microbiota and/or increased gut permeability, which is later seen as sensitization to allergens.

IgG and IgG 4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre Allergy Study birth cohort

“…Our systematic observations have been anticipated by studies limited to a few allergenic molecules. 13,14,18,20,29,30 Among Swedish children, allergic sensitization or symptoms correlated with high levels of IgG responses to ovalbumin, birch, and cat, 29 and IgG levels to b-lactoglobulin were greater in patients with mild-to-moderate atopic dermatitis than in control subjects. 30 In Finnish children IgG responses to ovalbumin were associated with allergic disorders.…”

“…Accordingly, it has been previously proposed that high levels of IgG to some allergens early in life might predict the development of IgE sensitization later in life. 20,21,38 Therefore this area of investigation is very complex, and further studies are now needed to define how default and preatopic IgG responses can be better discriminated.…”

“…[13][14][15][16][17][18][19] Also, it has been suggested that IgG responses in early childhood to certain allergenic molecules might even predict IgE sensitization later in life. 20,21 Altogether, information on the effect of the route of exposure and allergic predisposition on allergen-specific IgG responses is sparse, and no study in early childhood has simultaneously investigated the IgG repertoire to a wide range of molecules. Before 2000, most studies of allergen-specific IgG responses were performed with assays based on allergenic extracts.…”

Systematic review about 10 interventions in dermatitis. A document from the Latin American Society of Allergy, Asthma, and Immunology

“…Explanation. Primary prevention: the increase of IgA levels with breast milk 30 and the use of milk hydrolyzed formulas in high-risk infants reduced the cumulative prevalence of eczema. 31 Although these results are supported by some studies, other research studies do not reproduce these results, so their implementation cannot be widely recommended.…”

Quoi de neuf en allergologie pédiatrique en 2014 ? Épidémiologie générale, diagnostic (précoce), traitement, anaphylaxie, allergie alimentaire, médicamenteuse et aux venins et salives d’insectes (une revue de la littérature internationale 2014)

“…Dans la mesure où le lait de vache et la farine de blé sont les aliments prédominants des nourrissons, Orivuori et al ont dosé les IgA et IgG sériques spécifiques de ces allergènes chez plus de 1100 enfants âgés de 12 mois, et comparé les résultats de ces dosages, considérés comme des marqueurs d'exposition pré-coce, aux résultats des dosages des IgE sériques spécifiques d'une vingtaine de trophallergènes et aéro-allergènes courants, effectués à l'âge de 6 ans chez ces mêmes enfants [30]. Des questionnaires concernant les caractéristiques démographiques et cliniques des enfants ont également été remplis par les parents lorsque les enfants étaient âgés de 2-24 mois, puis lorsqu'ils étaient âgés de 6 ans.…”