Immunoglobulin serum levels in rituximab-treated patients with steroid-dependent nephrotic syndrome

Parmentier, Cyrielle; Delbet, Jean-Daniel; Decramer, Stéphane; Boyer, Olivia; Hogan, Julien; Ulinski, Tim

doi:10.1007/s00467-019-04398-1

Cited by 42 publications

(48 citation statements)

References 21 publications

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“…We found a high frequency of hypo-IgG levels post-rituximab treatment in the overall cohort (40.4%) as well as in the subgroup of patients with normal baseline IgG levels (31.0%), which is comparable to outcomes from recent reports. 28,30,52 A novel finding was the association of post-rituximab treatment hypo-IgG and the increased risk of severe infections requiring ED visits or hospitalizations. This highlights the importance of monitoring IgG as these patients may benefit from immunoglobulin replacement therapy and/or antibiotic prophylaxis, 15,[53][54][55][56][57][58] although more studies are needed to support their use.…”

Section: Discussionmentioning

confidence: 99%

Rituximab-induced hypogammaglobulinemia and infection risk in pediatric patients

Labrosse

Barmettler

Dérfalvi

et al. 2021

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Rituximab-induced hypogammaglobulinemia and infection risk in pediatric patients

Labrosse

Barmettler

Dérfalvi

et al. 2021

Journal of Allergy and Clinical Immunology

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“…1 Risk is also increased with the concomitant use of glucocorticoids and an increased number of doses of rituximab. 1,4 In a study by Parmentier et al, 5 they also found that those with low baseline IgG levels had a higher risk of hypogammaglobulinemia during treatment with rituximab and persistence after discontinuation.…”

Section: Introductionmentioning

confidence: 94%

Hypogammaglobulinemia following COVID-19 infection in a patient on maintenance rituximab

O’Bryan

Espinosa

Chittivelu

2021

SAGE Open Medical Case Reports

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Hypogammaglobulinemia is a known side-effect of rituximab use. It is typically asymptomatic and transient, although certain factors, such as maintenance dosing and concomitant glucocorticoid use can lead to symptomatic or prolonged hypogammaglobulinemia. Patients with symptomatic hypogammaglobulinemia leading to recurrent infections may be treated with intravenous immunoglobulin therapy. Herein, we report a case of a 49-year-old male on maintenance rituximab without prior respiratory symptoms with new onset recurrent pneumonia after COVID-19 pneumonia and treatment with glucocorticoids.

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“…Table XII), hypogammaglobulinemia is not uncommon in children with nephrotic syndrome and autoimmune diseases. The risk of hypogammaglobulinemia correlates inversely with age, and positively with the number of rituximab doses [94][95][96].…”

Section: Rationalementioning

confidence: 99%

Steroid Sensitive Nephrotic Syndrome: Revised Guidelines

Sinha

Bagga²,

Banerjee

et al. 2021

Indian Pediatr

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Justification Steroid sensitive nephrotic syndrome (SSNS) is one of the most common chronic kidney diseases in children. These guidelines update the existing Indian Society of Pediatric Nephrology recommendations on its management. Objective To frame revised guidelines on diagnosis, evaluation, management and supportive care of patients with the illness. Process The guidelines combine evidence-based recommendations and expert opinion. Formulation of key questions was followed by review of literature and evaluation of evidence by experts in two face-to-face meetings. Recommendations The initial statements provide advice for evaluation at onset and follow up and indications for kidney biopsy. Subsequent statements provide recommendations for management of the first episode of illness and of disease relapses. Recommendations on the use of immunosuppressive strategies in patients with frequent relapses and steroid dependence are accompanied by suggestions for step-wise approach and plan of monitoring. Guidance is also provided regarding the management of common complications including edema, hypovolemia and serious infections. Advice on immunization and transition of care is given. The revised guideline is intended to improve the management and outcomes of patients with SSNS, and provide directions for future research.

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Immunoglobulin serum levels in rituximab-treated patients with steroid-dependent nephrotic syndrome

Cited by 42 publications

References 21 publications

Rituximab-induced hypogammaglobulinemia and infection risk in pediatric patients

Rituximab-induced hypogammaglobulinemia and infection risk in pediatric patients

Hypogammaglobulinemia following COVID-19 infection in a patient on maintenance rituximab

Steroid Sensitive Nephrotic Syndrome: Revised Guidelines

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