Immunoglobulins and immunoglobulin genes of the horse

Wagner, Bettina

doi:10.1016/j.dci.2005.06.008

Cited by 100 publications

(54 citation statements)

References 52 publications

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“…This is similar to the interaction of IgG and the high-affinity FcγRI on human mast cells [21] and differs from binding of IgG to low affinity FcγRII and FcγRIII that requires prior IgG/allergen complex formation [22]. Equine IgG(T) is not an isotype; rather, it represents a fraction of equine IgG composed of IgG3 and IgG5 [31]. The anti-IgG(T) antibody CVS40 recognizes both isotypes, although it seems to have a higher affinity to IgG5 2 .…”

Section: Discussionmentioning

confidence: 92%

IgE and IgG antibodies in skin allergy of the horse

et al. 2006

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-In horses, allergies have been characterized by clinical signs and/or intradermal (i.d.) allergen testing. Our aim was to find the first direct evidence that immunoglobulin E (IgE) mediates equine allergy. In addition, we tested the hypothesis that immediate skin reactions in horses can also be mediated by IgG. Anti-IgE affinity columns were used to purify IgE from serum of one healthy horse and three horses affected with summer eczema, an allergic dermatitis which is believed to be induced by Culicoides midges. A modified Prausnitz-Küstner experiment was performed in four clinical healthy horses by i.d. injection of the purified serum IgE antibodies. The following day, Culicoides allergen was injected at the same sites. Skin reactions were not observed in response to allergen alone, and in two horses after stimulation at any previous IgE injection site. However, the other two horses showed an immediate skin reaction at the previous injection sites of IgE obtained from allergic horses. In addition, purified monoclonal antibodies to various equine immunoglobulin isotypes were injected i.d. into six healthy horses. Immediate skin reactions were observed in response to anti-IgE (6/6 horses) and anti-IgG(T) injections (5/6 horses). The specificities of both antibodies for IgE and IgG(T), respectively, were confirmed by enzyme linked immunosorbent assays. The results provide the first direct evidence that IgE mediates classical Type-I allergy in horses and plays a major role in the pathogenesis of summer eczema. The data also suggest that IgG(T) can bind to skin mast cells and might contribute to clinical allergy.horse / allergy / summer eczema / IgE / IgG

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Section: Discussionmentioning

confidence: 92%

IgE and IgG antibodies in skin allergy of the horse

et al. 2006

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“…In immunocompetent horses, the development of merozoite-specific IgGa and IgGb during acute T. equi infection correlates with control of parasitemia, while merozoite-specific IgG(T) appears only after resolution of parasitemia (1a). Equine IgG subclasses have been reassigned such that IgGa corresponds to IgG1, IgGb corresponds to IgG4 and IgG7, and IgG(T) primarily corresponds to IgG5 and, to a lesser extent, IgG3 (20)(21)(22). Since IgG1, IgG3, IgG4, and IgG7 all bind complement and interact with Fc receptors (6), complement activation and opsonization by T. equi merozoite-specific antibodies likely play important roles in resolution of acute parasitemia and maintenance of long-term control (1a).…”

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confidence: 99%

Protective Effects of Passively Transferred Merozoite-Specific Antibodies against Theileria equi in Horses with Severe Combined Immunodeficiency

Mealey

Kappmeyer

Ueti

et al. 2012

Clin Vaccine Immunol

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“…Additionally, in the Cγ IGHC sequence, Cγ1 IGHC was classified in the same cluster as the mouse and rat IgG1 subclass, and Cγ2 IGHC in our previous study was classified in the same cluster as the hamster IgG, mouse and rat IgG2 subclasses and mouse IgG3, respectively. The number of IgG subclasses varies among species, with four Cγ genes, Cγ1, Cγ2a, Cγ2b and Cγ3, in mice [13], four Cγ genes, Cγ1, Cγ2a, Cγ2b, and Cγ2c, in rats [1], one Cγ gene in rabbits [10] and seven Cγ genes, Cγ1, Cγ2, Cγ3, Cγ4, Cγ5, Cγ6, and Cγ7, in horses [17]. All five gerbils of the same inbred strain used in this study expressed both Cγ1 and Cγ2 IGHC mRNA, indicating that the gerbil has at least two IgG subclasses.…”

Section: Discussionmentioning

confidence: 99%

Sequence Determination of the Heavy-Chain Constant Region in Four Immunoglobulin Classes of Mongolian Gerbils (<i>Meriones unguiculatus</i>)

2012

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Abstract:We determined partial cDNA sequences of four immunoglobulin (Ig) classes-IgM, IgG1, IgE, and IgA-of Mongolian gerbil (Meriones unguiculatus). Each deduced Ig heavy-chain constant (IGHC) region-Cµ, Cγ1, Cε, and Cα-is structurally similar to its counterparts in the mouse and rat, and phylogenetic analysis suggests that the gerbil Igs are evolutionarily close to their counterparts. In spite of the high sequence homology to the other rodent Cγ sequences, the gerbil Cγ1 sequence differs from our previously reported Cγ2. This result indicates that the gerbil has at least two IgG subclasses. These four gerbil IGHC cDNA sequences will be useful for determining gerbil Ig isotypes and examining the expression of gerbil Ig mRNAs in response to parasitic and bacterial infections.

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Immunoglobulins and immunoglobulin genes of the horse

Cited by 100 publications

References 52 publications

IgE and IgG antibodies in skin allergy of the horse

IgE and IgG antibodies in skin allergy of the horse

Protective Effects of Passively Transferred Merozoite-Specific Antibodies against Theileria equi in Horses with Severe Combined Immunodeficiency

Sequence Determination of the Heavy-Chain Constant Region in Four Immunoglobulin Classes of Mongolian Gerbils (<i>Meriones unguiculatus</i>)

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