1991
DOI: 10.1016/0006-291x(91)91335-a
|View full text |Cite
|
Sign up to set email alerts
|

Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

5
55
1

Year Published

1993
1993
2003
2003

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 135 publications
(61 citation statements)
references
References 14 publications
5
55
1
Order By: Relevance
“…4B). These data are essentially identical to those previously reported with human Graves' sera (24,25), suggesting the crucial role of the N-terminal region of TSHR ectodomain in both human and murine TSI.…”
Section: Resultssupporting
confidence: 90%
See 1 more Smart Citation
“…4B). These data are essentially identical to those previously reported with human Graves' sera (24,25), suggesting the crucial role of the N-terminal region of TSHR ectodomain in both human and murine TSI.…”
Section: Resultssupporting
confidence: 90%
“…Our study with chimeric receptors suggests that the epitopes on TSHR recognized by TSI in our model appear very similar to those observed in human disease (24,25), suggesting the involvement of the N terminus of TSHR ectodomain in both human and murine TSI. This is in agreement with the studies by Kikuoka et al (37), who have shown the importance of the N terminus of TSHR ectodomain (domains A and B in our chimeras) in induction of Graves' hyperthyroidism with Shimojo's model.…”
Section: Discussionsupporting
confidence: 76%
“…CHO cells expressing hTSHR (26,27) were grown to confluence in 96-well plates in F-12 medium supplemented with 10% FBS. Before the assay, spent medium was removed, and cells were washed with fresh medium.…”
Section: Camp Assaymentioning
confidence: 99%
“…Purification has been hampered by the relatively small number of TSHR molecules expressed in mammalian cells and the functional instability of the protein. An important factor contributing to this difficulty is that TSHR autoantibodies predominantly recognize highly conformational epitopes (which are not necessarily identical with those that bind TSH) (Nagayama et al 1991, Tahara et al 1991.…”
Section: Introductionmentioning
confidence: 99%