Immunoglobulins, Immunoglobulin G Subclasses and Complement in Adult Omanis

Abstract

Immunoglobulins and complement were quantitated in 100 healthy adult Omanis in order to establish a reference range based on local data. Mean values were IgA 2.38 g/L, IgM 1.14 g/L, IgE 241 kiu/L, C3 7.44 mol/L and C4 1.57 mol/L, values similar to those found in the West. However, the mean level of IgG was almost 50% higher than that found in North America and Europe, that is, 14.63 g/L compared with 10-11 g/L. The values for IgG, IgA, IgM and IgE are similar to those reported for Iraq, but IgG levels were much lower than those found in Iran (25.52 g/L), although IgA, IgM and IgE were comparable. Comparison of Omani data with that for Saudi Arabia showed significantly more IgG in Oman (14.63 versus 11.68 g/L) and significantly less IgM (1.14 versus 1.66 g/L). IgA and IgE levels were similar. As reported elsewhere, females had significantly more IgM than males (1.32 versus 0.97 g/L). The levels of IgG subclasses in Oman are 9.44, 4.01, 1.06 and 0.62 g/L for IgG1-4 respectively. The percentage of the various subclasses are very similar to those reported elsewhere, that is, 62%, 27%, 7% and 4% for IgG1-4. However, in Iraq, a higher percentage (and level) of IgG3 (16%) and the lower IgG2 (18%) compared to Oman may reflect differing immune responses resulting from exposure to different microorganisms. It is essential to use local reference data when evaluating patients.

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“…The crude mean of IgG levels in the children of the current study (Table 5) is close to the average in Oman [30] and Helsinki-Finland [31], but higher than that observed in Spain [18], Kashmir (India) [22], California [32], and less than Nigeria [33].…”

Normal Value of Immunoglobulins IgA, IgG, and IgM in Iranian Healthy Adults, Measured by Nephelometry

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]21,22] However, some of those surveys have been cited as sources in international medical books. In clinical immunology, known immune system components and their normal values are very critical.…”

“…n Area IgA (mg/dL) IgG (mg/dL) IgM (mg/dL) Jolliff et al [8] 120 America 70-312 639-1,349 56-352 Shido et al [9] 88 a Africa 60-580 500-2,300 50-460 100 b Euro 70-320 710-1,520 30-120 White et al [15] 100 Asia 67-478 960-2,160 32-304 Lau et al [18] 80 Asia 134-453 900-2,080 66-366 NIH reports [32] - …”

“…To know normal levels of these effectors is important, especially for local reference. [8][9][10][11][12][13][14][15][16][17][18][19] Aims of these determinations was to study preparation of immunoglobulins references by nephelometric methods. [1] Levels of immunoglobulins may vary by gender and race, although these differences are generally not clinically significant; but, a knowledge of local reference values is important.…”