Immunohematology in Taiwan

Lin, Min; Broadberry, Richard E.

doi:10.1016/s0887-7963(98)80090-4

Cited by 45 publications

(48 citation statements)

References 52 publications

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“…As a result of these findings routine Rh (D) typing in Taiwanese hospital patients requiring blood transfusion has been discontinued. 4 However, due to relatively high prevalence of D negative (5e10%) in our population, D typing is a must for blood donors as well as for patients requiring blood transfusion in Indian scenario.…”

Section: Prevalence Of Rh (D) Positive and Rh (D) Negative Blood Donomentioning

confidence: 91%

Proportion of Rh phenotypes in voluntary blood donors

Sarkar

Philip

Mallhi

et al. 2013

Medical Journal Armed Forces India

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a b s t r a c tBackground: The Rh system is the major blood group system besides ABO system. Even after proper blood grouping and cross matching there is a possibility of alloimmunization and antibody production in the recipients against the Rh or minor blood group antigens like Results: The phenotypic frequencies of Rh blood groups in the studied population were D-92.25%, C-87.55%, E-26.55%, c-51.06% and e-98.42%. Thus 'e' was the most common and E was the least common of all the Rh types. Phenotypically DCCee group was the most common phenotype and dccee was least common type.Conclusion: Determination of Rh phenotypes can play a major role in preventing alloimmunization and avoiding adverse events in multitransfusion cases.ª 2013, Armed Forces Medical Services (AFMS). All rights reserved.

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Section: Prevalence Of Rh (D) Positive and Rh (D) Negative Blood Donomentioning

confidence: 91%

Proportion of Rh phenotypes in voluntary blood donors

Sarkar

Philip

Mallhi

et al. 2013

Medical Journal Armed Forces India

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“…By comparing the protein compositions of AE1-based complexes in erythrocyte ghosts obtained from Mi.III ϩ and nonMiltenberger (control) people, we found a significant increase of AE1 on Mi.III ϩ membrane. Their higher AE1 level was correlated with functional changes, including superior HCO 3 Ϫ -transporting capacities, acidbase homeostasis, and osmotic resistance, which contrast with the phenotype of certain kinds of hereditary spherocytosis characterized by a marked reduction of AE1 expression. By unveiling the functional relevance of the Miltenberger antigen, our work suggests that its evolutional emergence is beneficial.…”

Section: Introductionmentioning

confidence: 93%

“…26 Because Mi.III ϩ erythrocytes showed higher HCO 3 Ϫ /Cl Ϫ exchange capacities (Figure 4), we tested whether their differences were reflected in pH i homeostasis. Erythrocytes were loaded with fluorescent pH indicator carboxy SNARF-1, and the elicited pH i responses were quantified by flow cytometry.…”

Section: Higher Anion Exchange Capacity Of Miiii ؉ Erythrocytesmentioning

confidence: 99%

“…However, the frequencies are exceptionally high in several Taiwanese aboriginal tribes (up to 90%), compared with 2% to 3% in Han Taiwanese (Minnan). 3 Mi.III exhibits a unique glycophorin hybrid peptide (Gp.Mur), the likely product of specific gene insertion of GYPA into GYPB (denoted BAB as in Figure 1A). 4 Because transfusion with incompatible Miltenberger blood could result in severe hemolytic diseases, [5][6][7][8] blood bank screening of the Miltenberger phenotypes before transfusion is required in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

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Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3

Hsu

Chi

Guček

et al. 2009

Blood

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The special blood group antigen Mi.III exhibits a characteristic hybrid structure of glycophorin A (GPA) and glycophorin B, termed Gp.Mur. This phenotype has exceptionally high occurrence rates in several indigenous tribes in Taiwan (ϳ21.2%-88.4%). Because glycophorin/ Miltenberger begins interaction with anion exchanger-1 (AE1) in the endoplasmic reticulum, we hypothesized that the AE1-based macrocomplexes on erythrocyte membranes obtained from Mi.III ؉ people could be differentiated from those obtained from non-Miltenberger people. Quantitative mass spectrometric comparison of the AE1-based complexes by iTRAQ™ (Applied Biosystems) revealed 25% to 67% higher expression of AE1 in Mi.III ؉ erythrocytes. In accordance with the higher AE1 level, the Mi.III ؉ erythrocytes exhibited superior HCO 3 ؊ capacities, pH homeostasis, and osmotic resistance. Cotransfection experiments in HEK293 cells showed that Gp.Mur, like GPA, enhanced trafficking of AE1 to the plasma membrane. In summary, the increased surface expression of AE1 in Mi.III ؉ erythrocytes could be attributed to the additive effect of GPA and Gp

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“…Among Indian population, the frequency is 0.58 % [9]. In Taiwan, 1.2 % among the Paiwan tribe and 1 % among the Rukai tribe were detected as Jk null phenotype [10]. This rare phenotype has also been detected among the ethnic population of the Brazil, and Japan [5].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Anti-Jk3 Antibody Detected on Pre-Transfusion Investigation

Yousuf

Aziz

Yusof

et al. 2012

Indian J Hematol Blood Transfus

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We report a 47-year-old Malay lady, para 4 ? 1, with known medical history of hypertension whom presented at Emergency Department with severe anaemia, most likely secondary to menorrhagia caused by uterine fibroids. Her haemoglobin was 5.5 g/dl and she was transfused with three units of packed cell without any adverse reaction, her haemoglobin level increased to 9.8 g/dl. She was then planned for total abdominal hysterectomy and bilateral salpingooophorectomy later. Four months later when she came for the elective surgery, her pre transfusion investigations showed blood group as B Rh D positive, with a probable R1R1 phenotype. Her antibody screening was positive in all the three panel cells. Further testings showed a negative Direct Coomb's test and negative autocontrol, antibody identification showed pan-agglutination reaction on all 11 panel cells with enzyme enhancement. Patient's red cell phenotype was Jk(a-b-). Anti-Jk3 was suspected and further confirmed in the reference laboratory by phenotyping as well as negative urea lysis test. This case report highlights an extremely rare but clinically significant anti-JK3 antibody detected during pretransfusion testing. This phenotype is rare in the white population, more commonly seen in various polynesians. Increased awareness among the blood bank personnel regarding the variability of the blood group phenotype and the capricious nature of the Kidd antibodies may contribute to the better management of these patients.

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Immunohematology in Taiwan

Cited by 45 publications

References 52 publications

Proportion of Rh phenotypes in voluntary blood donors

Proportion of Rh phenotypes in voluntary blood donors

Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3

A Rare Case of Anti-Jk3 Antibody Detected on Pre-Transfusion Investigation

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