2011
DOI: 10.1111/j.1439-0264.2010.01059.x
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Immunohistochemical Analyses of NPAS3 Expression in the Developing Human Fetal Brain

Abstract: The NPAS3 gene encodes a transcription factor with disease roles in neurodevelopment, neoplasia and neurobehaviour. We report the first immunohistochemical findings on NPAS3 protein expression in the developing human fetal brain during the three trimesters (10-41 weeks) of gestational development. In the first trimester, NPAS3 expression is largely confined in the nucleus of cells of the ventricular zone. Similarly, strong nuclear expression in the hippocampus is noted as early as the first trimester, but with… Show more

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Cited by 18 publications
(24 citation statements)
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“…The present data are consistent with the known activity of NPAS3 in human fetal development, with increased expression in the radial glia of the ventricular zone during the first trimester and decreased expression in the intermediate progenitor cells of the subventricular zone later in development, 14 which suggests that normal NPAS3 expression has an important role in regulating the development and maturation of neural stem cells into mature glia. Current theories of gliomagenesis postulate that gliomas arise by transformation of residual neural stem cells or progenitor cells.…”
Section: Discussionsupporting
confidence: 78%
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“…The present data are consistent with the known activity of NPAS3 in human fetal development, with increased expression in the radial glia of the ventricular zone during the first trimester and decreased expression in the intermediate progenitor cells of the subventricular zone later in development, 14 which suggests that normal NPAS3 expression has an important role in regulating the development and maturation of neural stem cells into mature glia. Current theories of gliomagenesis postulate that gliomas arise by transformation of residual neural stem cells or progenitor cells.…”
Section: Discussionsupporting
confidence: 78%
“…18 Further detailed IHC analysis of NPAS3 expression during human fetal brain development revealed largely confined expression in the nucleus of cells in the ventricular zone and hippocampus in the first trimester, with more widespread progressive increases becoming more apparent in the molecular layer and layer III of the maturing neocortex during the second and third trimesters. 14 In a spatiotemporally controlled manner in the cerebellum, nuclear expression has also been identified in basket cells and in Bergmann's glia, with some cytoplasmic staining evident in the internal granule layer of neurons. 14 After initial cloning of the NPAS3 gene, 13 the objective of the present study was to investigate the role of this gene in diseases in human beings.…”
mentioning
confidence: 99%
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