Immunohistochemical analysis of Clara cell secretory protein expression in a transgenic model of mouse lung carcinogenesis

Jaagsiekte Sheep Retrovirus Infects Multiple Cell Types in the Ovine Lung

“…The most likely explanation for this is that CCSP expression is downregulated following transformation by JSRV as cells proliferate. CCSP is thought to antagonize the neoplastic phenotype, and reduced expression has been found in mature tumors known to be of Clara cell origin (35,44). Alternatively, infected CCSP-positive cells may lose JSRV expression, for example, through repression of the viral LTR.…”

Classification of Proliferative Pulmonary Lesions of the Mouse

“…INK4a (12,15,16,29,(55)(56)(57)(58)(59)(60)(61)(62). The majority of new genetic models develop adenomas and adenocarcinomas that are similar to spontaneous and chemically induced mouse neoplasms (12,15).…”

Site-specific Differences in Gene Expression of Secreted Proteins in the Mouse Lung: Comparison of Methods to Show Differences by Location

“…In human studies, CCSP levels in serum and lavage fluid serve as biomarkers of lung disease and lung injury (Shijubo et al 1997;Broeckaert et al 2000). In a transgenic mouse model used to study lung tumors arising from Clara cells, CCSP expression was found to be diminished in tumor cells (Hicks et al 2003). In mouse models of lung toxicity to naphthalene, a polycyclic aromatic hydrogen compound metabolically activated by cytochrome P450s in the Clara cells of the conducting airways, toxicity to the Clara cells was distributed in a site-specific manner depending on route of exposure and dose resulting in focal losses of the CCSPexpressing cell population (Warren et al 1982;Plopper et al 1992;Van Winkle et al 1995).…”