Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium

Mylonas, Ionannis

doi:10.1016/s0065-1281(04)00036-4

Cited by 15 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Up-regulation of 17bHSD-2 in human ESE vs. PE is also consistent with results from Mustonen et al [19]. The up-regulation of 17bHSD2 suggests that direct E 2 action in this phase is beginning to be curtailed, as a prelude to more pronounced curtailment in the mid-secretory phase in which estrogen receptors are down-regulated in the stroma and nearly completely absent in the epithelium [20-23]. …”

Section: Introductionsupporting

confidence: 87%

Application of functional genomics to primate endometrium: insights into biological processes

Giudice

2006

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Endometrium is a dynamic tissue that responds on a cyclic basis to circulating levels of the ovarianderived steroid hormones, estradiol and progesterone. Functional genomics has enabled a global approach to understanding gene regulation in whole endometrial tissue in the setting of a changing hormonal milieu. The proliferative phase of the cycle, under the influence of estradiol, has a preponderance of genes involved in DNA synthesis and cell cycle regulation. Interestingly, genes encoding ion channels and cell adhesion, as well as angiogenic factors, are also highly regulated in this phase of the cycle. After the LH surge, different gene expression profiles are uniquely observed in the early secretory, mid-secretory (window of implantation), and late secretory phases. The early secretory phase is notable for up-regulation of multiple genes and gene families involved in cellular metabolism, steroid hormone metabolism, as well as some secreted glycoproteins. The mid-secretory phase is characterized by multiple biological processes, including up-regulation of genes encoding secreted glycoproteins, immune response genes with a focus on innate immunity, and genes involved in detoxification mechanisms. In the late secretory phase, as the tissue prepares for desquamation, there is a marked up-regulation of an inflammatory response, along with matrix degrading enzymes, and genes involved in hemostasis, among others. This monograph reviews hormonal regulation of gene expression in this tissue and the molecular events occurring therein throughout the cycle derived from functional genomics analysis. It also highlights challenges encountered in using human endometrial tissue in translational research in this context.

show abstract

Section: Introductionsupporting

confidence: 87%

Application of functional genomics to primate endometrium: insights into biological processes

Giudice

2006

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

“…Hypersecretion of superficial epithelium were noted. The secretion cover the epithelial surface prevent to outflow of fluid from uterine glands [10].…”

Section: Discussionmentioning

confidence: 99%

Histological changes within ovarian cortex, oviductal and uterine mucosa in case of ovarian cysts presence in sows.

Szulańczyk

2009

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Abstract:The aim of study was histological evaluation of oviduct and uterus mucosa in case of cystical ovarian degeneration in sows. Materials for evaluations were received after slaughtering of 294 sows at age of 2-5 years. Sows were eliminated breeding and culled due to reproduction disorders: anoestrus after weaning of piglets, return of estrus, small litters and due to age, number of birth, bad condition after lactation. 20 sows (6.8%) had cysts on ovaries. Histological investigations were conducted on reproductive organs of sows with ovarian cysts. Sows were divided onto two groups: 1. with polycystic ovaries (12 sows), 2. with simple cyst (8 sows) occured unilaterally (3 sows) or bilaterally (5 sows). In our studies we noted different kids of ovarian cysts and structural changes in ovarian cortex like decreasing numbers of ovarian folliculi of all generations, increasing of follicular atresia. We compared the state of oviduct and uterus mucosa in case of polycystic ovaries with the histological changes in these tissues when single cysts were present on the ovaries. The single follicular cysts aren't accompanied with important changes in reproductive system. In case of polycystic ovaries the presence of cyst is connected with occurrence of morphological changes in endothelium of oviduct and uterus which would have been a reason of persistent infertility of pigs.

show abstract

“…Up-regulation of 17β-HSD-2 in human ESE vs PE is consistent with results from Mustonen et al 30 and supports the beginning of curtailment of direct E 2 action in this phase, as a prelude to more pronounced curtailment of E 2 action in the mid-secretory phase in which ERs are down-regulated in the stroma and nearly completely absent in the epithelium. [31][32][33][34] Transporters for amino acids, peptides, and ions are highly up-regulated in ESE vs PE, as are enzymes involved in collagen metabolism, a variety of cytochrome P 450 proteins (important in electron transport and energy pathways), and regulators of blood coagulation. Major inhibitors of the Wnt signaling, Dkk-1 and SFRP-1, are regulated, with Dkk-1 being increased six-fold, and SFRP-1 down-regulated.…”

Section: The Early Secretory Phasementioning

confidence: 99%

Transcriptomics

Giudice¹,

Talbi²,

Hamilton³

et al. 2008

Reproductive Medicine and Assisted Reproductive Techniques

View full text Add to dashboard Cite

Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium

Cited by 15 publications

References 0 publications

Application of functional genomics to primate endometrium: insights into biological processes

Application of functional genomics to primate endometrium: insights into biological processes

Histological changes within ovarian cortex, oviductal and uterine mucosa in case of ovarian cysts presence in sows.

Transcriptomics

Contact Info

Product

Resources

About