Immunohistochemical Analysis of Leucocyte Subsets in the Sinonasal Mucosa of Cats with Upper Respiratory Tract Aspergillosis

Whitney, Joanna; Krockenberger, M. B.; Day, Michael; Beatty, Julia A.; Dhand, Navneet K.; Barrs, Vanessa R.

doi:10.1016/j.jcpa.2016.08.001

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…This report describes disseminated A felis infection in a cat as a sequel to FRS. This case was included in a report of immunohistological findings in feline FRS, but case details were not provided 10 . At the time of diagnosis of FRS most affected cats are presented by their owners for signs associated with an orbital mass such as exophthalmos and ulcerative keratitis, because of extension of infection from the sino‐nasal cavity 5 .…”

Section: Discussionmentioning

confidence: 99%

Disseminated invasive aspergillosis caused by Aspergillus felis in a cat

Cormack

Donahoe

Talbot

et al. 2021

Veterinary Internal Medicne

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A 2‐year‐old male desexed Ragdoll cat with a 1‐year history of sneezing and nasal discharge presented with a large subcutaneous cervical mass, identified as the right medial retropharyngeal lymph node on computed tomography (CT). A right orbital mass, destructive sino‐nasal cavity disease and multiple pulmonary nodules were also identified. Aspergillus felis was cultured from the lymph node. After treatment with posaconazole and liposomal amphotericin B the lymph node enlargement and orbital mass resolved but left frontal sinus involvement and pulmonary lesions persisted despite additional caspofungin therapy. The cat was euthanized 14 months after diagnosis with dysphagia and chronic progressive exophthalmos. A meningeal granuloma with intravascular fungal hyphae was identified at post‐mortem and A felis was cultured from the left frontal sinus and a right retrobulbar fungal granuloma. This case demonstrates that disseminated disease is a possible sequel to invasive fungal rhinosinusitis caused by A felis in cats.

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Section: Discussionmentioning

confidence: 99%

Disseminated invasive aspergillosis caused by Aspergillus felis in a cat

Cormack

Donahoe

Talbot

et al. 2021

Veterinary Internal Medicne

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“…felis conidia have also been found in air [ 4 ], making infection of cats possible via disruption of soil or wind dispersal, such as could occur through the natural feline behaviours of digging, sniffing and grooming. Given that infection often occurs in brachycephalic purebred cats of Persian lineage [ 4 , 9 ], an immunogenetic defect may predispose cats to disease [ 10 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Discovery of Aspergillus frankstonensis sp. nov. during environmental sampling for animal and human fungal pathogens

et al. 2017

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Invasive fungal infections (IFI) due to species in Aspergillus section Fumigati (ASF), including the Aspergillus viridinutans species complex (AVSC), are increasingly reported in humans and cats. The risk of exposure to these medically important fungi in Australia is unknown. Air and soil was sampled from the domiciles of pet cats diagnosed with these IFI and from a nature reserve in Frankston, Victoria, where Aspergillus viridinutans sensu stricto was discovered in 1954. Of 104 ASF species isolated, 61% were A. fumigatus sensu stricto, 9% were AVSC (A. felis-clade and A. frankstonensis sp. nov.) and 30% were other species (30%). Seven pathogenic ASF species known to cause disease in humans and animals (A. felis-clade, A. fischeri, A. thermomutatus, A. lentulus, A. laciniosus A. fumisynnematus, A. hiratsukae) comprised 25% of isolates overall. AVSC species were only isolated from Frankston soil where they were abundant, suggesting a particular ecological niche. Phylogenetic, morphological and metabolomic analyses of these isolates identified a new species, A. frankstonensis that is phylogenetically distinct from other AVSC species, heterothallic and produces a unique array of extrolites, including the UV spectrum characterized compounds DOLD, RAIMO and CALBO. Shared morphological and physiological characteristics with other AVSC species include slow sporulation, optimal growth at 37°C, no growth at 50°C, and viriditoxin production. Overall, the risk of environmental exposure to pathogenic species in ASF in Australia appears to be high, but there was no evidence of direct environmental exposure to AVSC species in areas where humans and cats cohabitate.

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“…Immunohistochemical staining was performed using the following antibodies: CD3 (Dako, Australia Pty Ltd., North Sydney, NSW 2060, Australia, A0452, 1:400); CD79b (AbD Serotec, Abacus ALS, Meadowbrook, Qld 4131, Australia, MCA2209, 1:5000); and PAX5 (Leica Novocastra, Sigma-Aldrich, Castle Hill, NSW 1765, Australia, 1:100), as reported previously [ 26 , 27 ]. Briefly, 4 µm sections underwent endogenous peroxidase blocking for 15 min followed by heat-induced epitope retrieval for five minutes (Dako, S1699, S2367) and then incubation with the primary antibody at room temperature for 60 min.…”

Section: Methodsmentioning

confidence: 99%

Molecular Diagnosis of Felis catus Gammaherpesvirus 1 (FcaGHV1) Infection in Cats of Known Retrovirus Status with and without Lymphoma

McLuckie

Barrs

Lindsay

et al. 2018

Viruses

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The pathogenicity of Felis catus gammaherpesvirus 1 (FcaGHV1), a common infection of domestic cats, is unknown. To explore an association between FcaGHV1 detection and feline lymphoma, a retrospective, cross-sectional, disease-association study was conducted. The infection status of all cats for feline immunodeficiency virus and feline leukaemia virus was determined. Neither a molecular diagnosis of FcaGHV1 nor whole-blood FcaGHV1 load was related to outcome in 122 lymphoma cases compared with 71 controls matched for age and sex. Molecular analysis of lymphoma-derived DNA paired with autologous uninvolved tissue did not suggest restriction of FcaGHV1 DNA to tumour tissue. FcaGHV1 DNA detection was associated with significantly shorter survival in lymphoma cases, an observation that could not be adequately explained by treatment differences. In addition, regressive feline leukaemia virus infection was identified as a risk factor for lymphoma. A history of fighting or roaming was identified as a novel epidemiological risk factor for FcaGHV1 detection, lending support to intercat aggression as a potential route of transmission. Studies investigating the cellular location and expression of FcaGHV1 are indicated to assist in ruling out a lymphomagenic role for this virus. Prospective investigation of FcaGHV1 DNA detection as a prognostic marker in feline lymphoma is warranted.

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Immunohistochemical Analysis of Leucocyte Subsets in the Sinonasal Mucosa of Cats with Upper Respiratory Tract Aspergillosis

Cited by 6 publications

References 40 publications

Disseminated invasive aspergillosis caused by Aspergillus felis in a cat

Disseminated invasive aspergillosis caused by Aspergillus felis in a cat

Discovery of Aspergillus frankstonensis sp. nov. during environmental sampling for animal and human fungal pathogens

Molecular Diagnosis of Felis catus Gammaherpesvirus 1 (FcaGHV1) Infection in Cats of Known Retrovirus Status with and without Lymphoma

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