Immunohistochemical and biochemical study of alkaline phosphatase in bone tumors and tumorous conditions - With special notes on giant cells.

Okajima, Keiichiro

doi:10.1267/ahc.20.41

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…As the macrophage‐like cells and the giant cells did not persist in culture of GCRG tissue, our findings suggest that the proliferative component of GCRG is a mesenchymal stromal cell which has the capacity to differentiate along fibroblast/osteoblast lines. The ability of proliferating stromal cells to differentiate into osteoblastic cells has been reported by other authors in giant cell‐containing tumours 26–28.…”

Section: Discussionsupporting

confidence: 61%

Phenotypic characterization of mononuclear and multinucleated cells of giant cell reparative granuloma of small bones

Itonaga

Schulze

Burge

et al. 2002

The Journal of Pathology

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Four cases of giant cell reparative granuloma (GCRG) of small bones were analysed in order to determine the pathogenesis of the lesion and the nature of the component mononuclear and multinucleated cells. In cell cultures, giant cells formed a non-proliferating homogeneous population which expressed features characteristic of the osteoclast phenotype, including leucocyte common antigen, CD68, vitronectin receptor, and tartrate-resistant acid phosphatase. The giant cells were capable of lacunar resorption and their activity was inhibited by calcitonin. In addition to numerous macrophage-like cells, some of which expressed osteoclast phenotypic characteristics, there were also mononuclear stromal cells which proliferated in culture and were alkaline phosphatase-positive; these cells expressed receptor activator of NF-kappaB ligand (RANKL) and were capable of supporting human osteoclast formation from circulating precursors in vitro. These findings suggest that the osteoclast-like giant cells in GCRG of small bones are formed from monocyte/macrophage-like osteoclast precursors which differentiate into osteoclasts under the influence of mononuclear osteoblast-like stromal cells.

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Section: Discussionsupporting

confidence: 61%