Immunohistochemical and electrophysiological evidence that locust ocellar photoreceptors contain and release histamine

Schlemermeyer, Etha; Schütte, Michael; Ammermüller, Josef

doi:10.1016/0304-3940(89)90267-x

Cited by 29 publications

(8 citation statements)

References 15 publications

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“…Since hdc mutants are characterized by the absence of the on-/off-transients in the ERG, it follows that mutations in the histidine decarboxylase gene which block the synthesis of histamine, also block the generation of the postsynaptic responses in the laminar interneurons. These results provide strong genetic support to a growing body of evidence suggesting that histamine is the major transmitter released by photoreceptors of many invertebrates (Elias and Evans, 1983;Hardie, 1987Hardie, , 1988Hardie, , 1989Simmons and Hardie, 1988;Nassel et al, 1988;Pirvola et al, 1988;Schlemermeyer et al, 1989;Battelle et al, 1991;Pollack and Hofbauer, 1991;Sarthy, 1991).…”

Section: Discussionsupporting

confidence: 70%

“…Histamine immunocytochemistry performed on a number of invertebrates by previous workers has demonstrated the presence of histamine-like immunoreactivity in photoreceptor endings (Nassel et al, 1988(Nassel et al, , 1990Pirvola et al, 1988;Schlemermeyer et al, 1989;Battelle et al, 1991;Homberg and Hildebrand, 1991;Pollack and Hofbauer, 1991;Sarthy, 1991). Some of the studies have shown, in addition, histamine-like immunoreactivity in a small number of neurons in the brain (Nassel et al, 1990;Pollack and Hofbauer, 1991) and thoracic and abdominal ganglia (Nassel et al, 1990).…”

Section: Discussionmentioning

confidence: 96%

“…Several lines of biochemical, immunocytochemical and physiological evidence suggest that histamine is the major transmitter used by invertebrate photoreceptors (Elias and Evans, 1983;Hardie, 1987Hardie, , 1988Nassel et al, 1988Nassel et al, , 1990Pirvola et al, 1988;Simmons and Hardie, 1988;Hardie, 1989;Schlemermeyer et al, 1989;Battelle et al, 1991;Pollack and Hofbauer, 1991). In Drosophila also, immunocytochemical and biochemical data have shown that histamine is a major transmitter used by all photoreceptors in the compound eye (Sarthy, 1991).…”

Section: Introductionmentioning

confidence: 99%

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Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis.

et al. 1993

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Drosophila mutants of a single complementation group with defective on‐/off‐transients of the electroretinogram (ERG) were found to be deficient in synthesis of the photoreceptor transmitter, histamine, in a gene‐dosage dependent manner, suggesting that the gene identified by the mutants (hdc) might be the structural gene for Drosophila histidine decarboxylase (HDC). A rat HDC cDNA was used to isolate a Drosophila homolog which shows approximately 60% sequence identity with mammalian HDCs over a region of 476 amino acids. In RNA blots, the Drosophila homolog detects four transcripts that are expressed primarily in the eye and are severely reduced in hdc mutants. The cloned Drosophila cDNA hybridizes to the 46F region of the chromosome, to which hdc mutations have been mapped, and rescues the hdc mutant phenotype in transgenic flies generated by P element‐mediated germline transformation. The results thus show that the Drosophila homolog corresponds to the histidine decarboxylase gene, identified by the hdc mutants, and that mutations in the gene disrupt photoreceptor synaptic transmission.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis.

et al. 1993

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“…In insects, the neurotransmitter function of HA has been most convincingly demonstrated in insect visual systems (Hardie 1987(Hardie , 1988(Hardie , 1989Simmons and Hardie 1988;Schlemermeyer et al 1989). Large amounts of HA determined biochemically in the optic lobes (Elias and Evans 1983;Sarthy 1991) can be perfectly correlated with the effects of HA on lamina monopolar cells shown in physiological experiments (Hardie 1987(Hardie , 1988(Hardie , 1989.…”

Section: Introductionmentioning

confidence: 92%

The distribution of histamine-immunoreactive neurons in the ventral nerve cord of the cricket, Gryllus bimaculatus

Hörner

Helle

Schürmann

1996

Cell and Tissue Research

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The present study demonstrates the immunocytochemical localisation of the biogenic amine, histamine (HA), in interneurons within the ventral nerve cord of the cricket, Gryllus bimaculatus. Analysis of whole-mount preparations combined with histology of serial sections reveals a constant number of HA-immunoreactive (HA-ir) neurons in the suboesophageal (n=8), thoracic (n=4) and abdominal ganglia (females/males n=24/20). Except for the suboesophageal and prothoracic ganglion, each thoracic and abdominal neuromere contains one pair of bilateral-symmetric HA-ir somata in a medio-ventral position. Axons from HA-ir cells in the thorax extend anteriorly and share common projection areas in thoracic associative neuropils; they terminate in the brain. HA-ir cells also display efferent descending axons. Extending posteriorly, these axons give rise to varicose HA-ir fibre plexuses on the surface of nerve 1 of the abdominal ganglia. In the suboesophageal ganglion, processes from a bilateral symmetric group of clustered HA-ir cells ascend into the tritocerebrum of the brain and further project into the frontal ganglion and the recurrent nerve. Ultrastructural analysis reveals dense-core vesicles, indicative of non-synaptic secretion, in HA-ir elements within the stomatogastric nervous system. Arborisations of HA-ir neurons are present in all major neuropil regions of the ventral nerve cord and display characteristic varicose structures also detected in other types of amine-containing cells. Central HA-ir varicose projections in dorsal and ventral neuropils are located in close apposition to the ganglionic surface. The wide-spread innervation of all neuromeres by HA-ir interneurons and the identification of possible neurohemal release sites suggest a general role of HA as a neuroactive substance, including neuromodulatory and neurohormonal functions.

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“…Physiological evidence supports a transmitter role of histamine in locust photoreceptors both in the compound eye (Schmidt et al 1998) and in the ocelli (Simmons and Hardie 1988;Schlemermeyer et al 1989). In the migratory locust Locusta migratoria, histamine, in addition, mimicks the inhibitory effects of an extraocular brain photoreceptor on the activity of a descending interneuron (Lundquist et al 1996).…”

Section: Introductionmentioning

confidence: 94%

Immunocytochemistry of histamine in the brain of the locust Schistocerca gregaria

Gebhardt

Homberg

2004

Cell Tissue Res

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Histamine serves a neurotransmitter role in arthropod photoreceptor neurons, but is also present in a small number of interneurons throughout the nervous system. In search of a suitable model system for the analysis of histaminergic neurotransmission in insects, we mapped the distribution of histamine in the brain of the desert locust Schistocerca gregaria by immunocytochemistry. In the optic lobe, apparently all photoreceptor cells of the compound eye with projections to the lamina and medulla showed intense immunostaining. Photoreceptors of the dorsal rim area of the eye had particularly large fiber diameters and gave rise to uniform varicose immunostaining throughout dorsal rim areas of the lamina and medulla. In the locust midbrain 21 bilateral pairs of histamine-immunoreactive interneurons were found, and 13 of these were reconstructed in detail. While most neuropil areas contained a dense meshwork of immunoreactive processes, immunostaining in the antennal lobe and in the calyces of the mushroom body was sparse and no staining occurred in the pedunculus and lobes of the mushroom body, in the protocerebral bridge, and in the lower division of the central body. A prominent group of four immunostained neurons had large cell bodies near the median ocellar nerve root and descending axonal fibers. These neurons are probably identical to previously identified primary commissure pioneer neurons of the locust brain. The apparent lack in the desert locust of certain histamine-immunoreactive neurons which were reported in the migratory locust may be responsible for differences in the physiological role of histamine between both species.

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Immunohistochemical and electrophysiological evidence that locust ocellar photoreceptors contain and release histamine

Cited by 29 publications

References 15 publications

Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis.

Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis.

The distribution of histamine-immunoreactive neurons in the ventral nerve cord of the cricket, Gryllus bimaculatus

Immunocytochemistry of histamine in the brain of the locust Schistocerca gregaria

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