2003
DOI: 10.1034/j.1600-0714.2003.00145.x
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Immunohistochemical and genetic analysis of mandibular cysts in heterozygous ptc knockout mice

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Cited by 31 publications
(40 citation statements)
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“…A similar variability in findings between different studies is also observed for the association of VEGF-A expression with clinical stage or nodal status. Some reports (Salven et al, 1997;Maeda et al, 1998;Neuchrist et al, 1999;Do et al, 2004), including our study, show no correlation between VEGF-A protein levels and these clinicopathological parameters, whereas others reported a relationship (Eisma et al, 1999;Mineta et al, 2000;Tae et al, 2000;Lim et al, 2003). These conflicting results highlight the necessity to perform retrospective studies using reliable methodology (preferentially quantitative) and a large cohort of patients.…”
Section: Discussionmentioning
confidence: 43%
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“…A similar variability in findings between different studies is also observed for the association of VEGF-A expression with clinical stage or nodal status. Some reports (Salven et al, 1997;Maeda et al, 1998;Neuchrist et al, 1999;Do et al, 2004), including our study, show no correlation between VEGF-A protein levels and these clinicopathological parameters, whereas others reported a relationship (Eisma et al, 1999;Mineta et al, 2000;Tae et al, 2000;Lim et al, 2003). These conflicting results highlight the necessity to perform retrospective studies using reliable methodology (preferentially quantitative) and a large cohort of patients.…”
Section: Discussionmentioning
confidence: 43%
“…Furthermore, VEGF-A has been described as an important prognostic factor in many types of human cancers (Dvorak, 2002). Several retrospective studies in HNSCC have demonstrated that VEGF-A expression is associated with clinicopathological factors and/or poor patient's outcome, suggesting that VEGF-A could serve as a prognostic marker (Eisma et al, 1997;Maeda et al, 1998;Mineta et al, 2000;Smith et al, 2000;Lim et al, 2003;Kimura et al, 2004;Uehara et al, 2004;Kyzas et al, 2005b). However, the status of VEGF-A remains unclear since other HNSCC retrospective studies have shown no correlation between VEGF-A expression and tumour prognosis (Salven et al, 1997;Tae et al, 2000;Do et al, 2004;Schimming et al, 2004).…”
mentioning
confidence: 99%
“…4 El factor de crecimiento endotelial vascular muestra una asociación con la expresión del p53 y tiene valor pronósti-co en los carcinomas de glándulas salivares. 5 El papel de la radioterapia mejorando el control local y regional es constatado por Terhaard en un importante estudio en 538 pacientes. 6 Aunque parezca sorprendente, es difícil conocer la incidencia real de cáncer en España.…”
unclassified
“…La base de datos GLOBOCAN 4 The vascular endothelial growth factor shows an association with the expression of p53 and it has prognostic value in salivary gland carcinoma. 5 The role of radiotherapy for improving local and regional control is confirmed by Terhaard in an important study 6 en el año 2002; considerando que los tumores de glándulas salivares suponen un 3%, la incidencia anual de estas neoplasias sería de 345 casos (sería un cálculo indirecto y aproximado, ya que no hace estimación directa sobre glándulas salivares).…”
unclassified
“…VEGF, in fact, is associated with several factors, such as the age of the patient, the dimensions of the tumour, the presence of lymphonodal metastasis, perineural invasion, vascular invasion, recurrence and survival (16). Recent studies (17) have shown how VEGF is involved in the proliferation of solid tumours, not only as a potent chemo-attractor for the preosteoclasts (18), but also as a molecule able to stimulate osteoclastic differentiation, as well as having a direct effect on the already differentiated osteoclasts (19).…”
mentioning
confidence: 99%