Immunohistochemical and Morphologic Features of Chordomas in Ferrets (<i>Mustela putorius furo</i>)

Herron, Alan J.; Brunnert, Steven R.; Ching, Shelley; Dillberger, John E.; Altman, Norman H.

doi:10.1177/030098589002700411

Cited by 19 publications

(22 citation statements)

References 6 publications

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“…51 In such cases, perform spinal radiography and myelography to identify a site for surgical approach. 8,23,51 Chondrosarcoma of the tail has also been described in ferrets. 51 In the tail, chordomas appear as lobulated, firm, nonencapsulated, ulcerated masses at or near the last caudal vertebra.…”

Section: Spinal Tumors Chordomas and Chondrosarcomasmentioning

confidence: 99%

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Musculoskeletal and Neurologic Diseases

Antinoff¹,

Giovanella²

2012

Ferrets, Rabbits, and Rodents

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Section: Spinal Tumors Chordomas and Chondrosarcomasmentioning

confidence: 99%

“…51 In the tail, chordomas appear as lobulated, firm, nonencapsulated, ulcerated masses at or near the last caudal vertebra. 8,23 In ferrets with any distal tail mass, amputate several vertebrae proximal to the lesion. 8,23,51 Chondrosarcoma of the tail has also been described in ferrets.…”

Section: Spinal Tumors Chordomas and Chondrosarcomasmentioning

confidence: 99%

Musculoskeletal and Neurologic Diseases

Antinoff¹,

Giovanella²

2012

Ferrets, Rabbits, and Rodents

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“…6,9 Chordomas are derived from notochord (mesoderm) and, in ferrets, tend to localize to the distal tail, although these tumors have been seen in the cervical and thoracic regions. 6,9,18 Thus far, reports of teratomas in ferrets have been limited to the reproductive system and the adrenal glands (Williams B: 1996, Bilateral adrenal teratomas). 3,19,24 The origin of teratomas remains controversial.…”

Section: Intramedullary Lumbosacral Teratoma In a Domestic Ferret (Mumentioning

confidence: 99%

Intramedullary lumbosacral teratoma in a domestic ferret (Mustela putorius furo)

et al. 2012

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Teratomas are germ cell neoplasms derived from 2 or more of the totipotential cell lines (ectoderm, mesoderm, endoderm). 5 The gonads are the most common location for development of teratomas in human beings and animals; however, these tumors can also develop at extragonadal locations, usually along the midline axis of the body. 5,13 Extragonadal teratomas have been infrequently reported in wild and domestic animals involving cutaneous structures, the alimentary tract, the kidneys, and retroperitoneal space, as well as other systems. 2,8,15,21 Descriptions of teratomas of the central nervous system are rare in both human beings and animals.17 Spinal teratomas in human beings are more common in pediatric patients, in whom they are typically observed in the sacrococcygeal region. 10,11,17 These tumors tend to be cystic, extradural structures localized proximal to the sacrum. In contrast, teratomas of the spinal cord in adults are usually found in the thoracolumbar spine. 17 Intraspinal teratomas account for 3%-9% of all intraspinal tumors in children, and although it is not possible to determine their incidence in domestic animals, reports of these conditions are exceedingly rare. 4 A recent report described a cervical spinal cord teratoma in a Giant Schnauzer and summarized the literature on canine intraspinal teratomas. 25In the ferret, teratomas have been described in the ovaries, uterus, and adrenal glands (Williams B: 1996, Bilateral adrenal teratomas in a domestic ferret (Mustela putorius furo). Vet Pathol 33:587. Abstract). 3,19,24 The current report describes the clinical, radiographic, and microscopic features of an intramedullary teratoma in a domestic ferret.An 18-month old, female, spayed domestic ferret (Mustela putorius furo) weighing 415 g presented to the University of Wisconsin, School of Veterinary Medicine (UWVMTH; Madison, Wisconsin) with a 2-week history of anorexia and lethargy. The ferret was fed a commercial ferret diet and lived in a large cage with 6 other ferrets. The owners reported that 1 week prior to presentation, the ferret seemed weak in the hind legs and could no longer climb. The ferret had been examined by the referring veterinarian (RDVM) 5 days prior to presentation for diarrhea, which coincided with the onset of hind limb paresis. The results of a plasma biochemistry panel determined by the RDVM were consistent with a mild hypoalbuminemia (2.6 g/dl, reference interval: 3.4-4.8 g/dl) and mild hyperglobulinemia (3.2 g/dl, reference interval: 0.2-2.4 g/dl). The results of a complete blood cell count (CBC) were unremarkable. The RDVM prescribed metronidazole (22 mg/kg orally every 12 hr) for the diarrhea. Despite medical therapy, there was no significant improvement in clinical signs, and the ataxia progressed.On presentation to the UWVMTH, the ferret was alert and mentally appropriate but small for its age and cachexic (body condition score of 1.5/9), with pronounced generalized muscle wasting. The perineal skin was hyperemic and wet from urine scalding, and the anus was swollen...

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“…Up to now, only a few reports have been published about chordomas in dogs (Jabara and Jubb, 1971; Pease et al, 2002; Munday et al, 2003), mink (Hadlow, 1984), rats (Stefanski et al, 1988), cats (Carpenter et al, 1990; Carminato et al, 2008) and ferrets (Herron et al, 1990; Dunn et al, 1991; Williams et al, 1993). Chordomas originate from remnants of the notochord and may arise anywhere along the vertebral column, but most commonly involve the cranial and caudal limits of the axial skeleton (Carminato et al, 2008).…”

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Chordoma in the Tail of a Ferret

et al. 2011

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A chordoma is an uncommon tumor that originates from the remnants of the notochord and most commonly involves the cranial and caudal regions of the axial skeleton. Chordoma has been described in laboratory animals such as dogs, rats, minks, and ferrets. This report describes a case of a chordoma in the tail of a ferret. Grossly, a grayish-white, expansile, subcutaneous soft-tissue mass was observed in the tail. Histopathologically, the mass was a loosely placed, nodular, unencapsulated neoplasm within the dermis. In the mass, tumor lobules were intermingled with fibrous tissues. Fibrous tissues contained abundant extracellular basophilic material that was consistent with mucin. The tumor was composed of a close pack of adipocyte-like vacuolated cells (physaliferous cells). The cells were centrally or eccentrically located round nuclei and eosinophilic cytoplasm with large vacuoles. Immunohistologically, neoplastic cells were positive for vimentin and S-100 protein. Based on histopathologic findings and special staining characteristics, this case was diagnosed as chordoma.

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Immunohistochemical and Morphologic Features of Chordomas in Ferrets (Mustela putorius furo)

Cited by 19 publications

References 6 publications

Musculoskeletal and Neurologic Diseases

Musculoskeletal and Neurologic Diseases

Intramedullary lumbosacral teratoma in a domestic ferret (Mustela putorius furo)

Chordoma in the Tail of a Ferret

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