Immunohistochemical assessment of proliferative activity in mammary adenomyoepithelioma

Koyama, Masaaki; Kurotaki, Hidekachi; Yagihashi, Norito; Aizawa, Shunji; Sugai, Michihiro; Kamata, Yoshimasa; Oyama, Toshio; Yagihashi, Soroku

doi:10.1046/j.1365-2559.1997.2100842.x

Cited by 21 publications

(12 citation statements)

References 9 publications

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“…This suggests that an aberrant subcellular localization of p27/Kip-1 in the neoplastic myoepithelial cells could abrogate its growth-inhibiting function and contribute to tumorigenesis via the unrestricted proliferation of the myoepithelial component. In fact, proliferating cells were found preferentially among the myoepithelial cells, which could thus represent a stem or reserve compartment of this tumor, as also recently demonstrated in mammary adenomyoepitheliomas (23). Furthermore, a significant inverse relationship was noted between the expression of cell cycle inhibitor p27/Kip-1 protein and the proliferative activity in both cell types.…”

Section: Discussionsupporting

confidence: 75%

Pulmonary Epithelial-Myoepithelial Tumor of Unproven Malignant Potential: Report of a Case and Review of the Literature

et al. 2001

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Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelialmyoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor.

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Section: Discussionsupporting

confidence: 75%

Pulmonary Epithelial-Myoepithelial Tumor of Unproven Malignant Potential: Report of a Case and Review of the Literature

et al. 2001

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“…18 Immunohstochemically, both epithelial and myoepithelial elements are keratin positive, with the latter elements also positive for smooth muscle actin and S100. 25,26 Malignant change may occur within these lesions. 18,[27][28][29] Adenoid cystic carcinoma a third tumour that can occur in the breast, is thought to be derived from myoepithelial cells, and is usually smooth muscle actin and S100-positive and ER negative.…”

Section: Discussionmentioning

confidence: 99%

Myoepithelial markers are expressed in at least 29% of oestrogen receptor negative invasive breast carcinoma

Kesse‐Adu

Shousha

2004

Modern Pathology

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Around 20% of invasive breast carcinoma are oestrogen receptor alpha (ER) negative. Theoretically, this negativity could be either due to the result of downregulation of ER expression in the tumour cells, or the result of the tumour being derived from or differentiating towards cells which normally lack that expression. Normal basal, including myoepithelial, cells of the breast are ERnegative. CD10, smooth muscle actin and S100 are markers of these basal cells that can be used for their demonstration in routinely processed sections. This study was aimed at comparing the incidence of positivity for three myoepithelial markers in ER-negative and ER-positive invasive breast carcinoma. We have examined sections of 117 cases of breast carcinoma, including 77 ER-negative and 40 ER-positive cases, for the expression of CD10, smooth muscle actin and S100, using the avidin-biotin complex immunoperoxidase technique. A tumour was considered positive if more than 10% of the tumour cells were positively stained. In all, 36 (47%) ER-negative tumours were positive for one or more of these myoepithelial markers. The percentage of positively stained tumour cells varied between 30 and 100%. Of the 40 ER-positive tumours, only three (8%) were positive; two for S100 and one for actin, with none being positive for CD10. If cases stained only with S100 are excluded, as some of these may represent luminal differentiation, definite myoepithelial differentiation seems to be present in 29% (22/77) of ER-negative tumours as compared with 2.5% (1/40) of ER-positive tumours; a difference which is highly significant (Po0.001). It is suggested that at least 29% of ER-negative invasive breast carcinomas may be derived from or differentiating along the direction of basal nonconventional luminal epithelial breast cells that normally lack the expression of ER but totally or partially express various myoepithelial markers. Such tumours might need a different therapeutic approach.

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“…We would like to comment on the article by Koyama et al 1 . which studies cell proliferation in mammary adenomyoepithelioma using the MIB1 (Ki67) antigen in association with phenotypic markers for epithelial and myoepithelial differentiation.…”

mentioning

confidence: 99%

Proliferation in adenomyoepitheliomas

Fonseca

Soares

1998

Histopathology

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Immunohistochemical assessment of proliferative activity in mammary adenomyoepithelioma

Abstract: These results might account for the previous findings that myoepithelial components predominate over the epithelial ones in an advanced stage of this tumour as well as in recurrent or metastatic lesions.

Cited by 21 publications

References 9 publications

Pulmonary Epithelial-Myoepithelial Tumor of Unproven Malignant Potential: Report of a Case and Review of the Literature

Pulmonary Epithelial-Myoepithelial Tumor of Unproven Malignant Potential: Report of a Case and Review of the Literature

Myoepithelial markers are expressed in at least 29% of oestrogen receptor negative invasive breast carcinoma

Proliferation in adenomyoepitheliomas

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