Immunohistochemical characteristics of basal-like breast cancer

Badowska-Kozakiewicz, Anna M.; Budzik, Michał P.

doi:10.5114/wo.2016.56938

Cited by 37 publications

(31 citation statements)

References 38 publications

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“…7I and J and Supplementary Table S4). This suggests that the control of ∆Np63 by TGFβ could be more relevant in breast cancers with low levels of ∆Np63 (luminal subtype) than in those with high levels of ∆Np63 (basal subtype) (39)(40)(41)(42). In summary, these data demonstate a negative correlation between TGFβ and ΔNp63 signatures in subtypes of breast and lung tumors, further providing evidence for the regulatory axis of TGFβ/ΔNp63 in human cancers.…”

Section: Tgfβ/micrornas Axis Is Required For the Downregulation Of δNmentioning

confidence: 67%

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis

et al. 2020

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∆Np63 is a transcription factor of the p53 family and has crucial functions in normal development and disease. The expression pattern of ∆Np63 in human cancer suggests dynamic regulation of this isoform during cancer progression and metastasis. Many primary and metastatic tumors express high levels of ∆Np63, while ∆Np63 loss is crucial for tumor dissemination, indicating an oscillatory expression of ∆Np63 during cancer progression. Here we use genetically engineered orthotopic mouse models of breast cancer to show that while depletion of ΔNp63 inhibits primary mammary adenocarcinoma development, oscillatory expression of ΔNp63 in established tumors is crucial for metastatic dissemination in breast cancer. A TGFβ-regulated microRNA network acted as upstream regulators of this oscillatory expression of ΔNp63 during cancer progression. This work sheds light on the pleiotropic roles of ∆Np63 in cancer and unveils critical functions of TGFβ in the metastatic process. SIGNIFICANCE This study unveils TGFβ signaling and a network of 4 microRNAs as upstream regulators of ∆Np63, providing key information for the development of therapeutic strategies to treat cancers that commonly overexpress ΔNp63. Research.

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Section: Tgfβ/micrornas Axis Is Required For the Downregulation Of δNmentioning

confidence: 67%

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis

et al. 2020

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“…1D ). However, basal-like breast cancer could predict bad prognosis, as 75–80% of the triple-negative breast cancers (TNBC) belonged to the group of basal-like breast cancer ( 20 ). High levels of CXXC5 expression could predict a bad prognosis in TNBC with MR via CXXC5 univariate Cox analysis (basal-like and/or TNBC) but not in the other group ( Tables II and III ).…”

Section: Resultsmentioning

confidence: 99%

Overexpression of CXXC5 is a strong poor prognostic factor in ER+ breast cancer

et al. 2018

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CXXC5 is a newly identified CXXC-type zinc finger family protein, which is encoded by the CXXC5 gene localised to the 5q31.3 chromosomal region. Previous studies revealed that CXXC5 is associated with various malignant tumours. The aim of the present study was to investigate the prognosis prediction of CXXC5 in different breast cancer subtypes via the Gene Expression Omnibus database and bc-GenExMiner. CXXC5 overexpression was observed as associated with a poor prognosis for oestrogen receptor positive (ER+) breast cancer. Basal-like breast cancer and triple-negative breast cancer also suggest a poor prognosis, however their CXXC5 expression was low and could not be used as a prognostic factor. The CXXC5 correlated genes and their enriched Gene Ontology (GO) terms were obtained. Among those enriched GO terms, GO:0070062 (extracellular exosome) had the greatest number of associated genes and the associated genes of GO:0000122 (negative regulation of transcription from RNA polymerase II promoter) and GO:0008134 (transcription factor binding) contained CXXC5. These results suggest that overexpression of CXXC5 is a strongly poor prognostic factor in ER+ breast cancer. However, the role of CXXC5 in breast cancer requires further investigation.

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“…So differentiating BBC from NBC shows great significance in clinical work. Basal-like breast cancers are those which expressing both CK5/6 and EGFR, higher CK5/6 and EGFR expression demonstrated significantly more often central nervous system and lung recurrence but very rarely to the bones and liver [ 34 ]. BBCs always have poor prognosis, and are difficult in treatment because of lacking effective targeted therapies [ 17 – 18 , 35 ] However, BBCs respond to chemotherapy using anthracyclines and taxanes fortunately [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Mammography and ultrasound effective features in differentiating basal-like and normal-like subtypes of triple negative breast cancer

Zeng

Hou

et al. 2017

Oncotarget

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The aim of our study was to find effective features of mammography and ultrasound in differentiating Basal-like breast cancer (BBC) and Normal-like breast cancer (NBC), two subtypes of triple negative breast cancer (TNBC). From January 2014 to March 2017, we retrospectively reviewed 91 patients who were pathologically confirmed as TNBC. According to immunohistochemical cytokeratin 5/6 (CK5/6) and Epidermal Growth Factor Receptor (EGFR), TNBCs were classified into BBCs group and NBCs group. Both CK5/6 and EGFR were negative defined to be NBC, whereas if any of CK5/6 or EGFR was positive then defined as BBC. BBCs group concluded 65 (71.4%) cases and NBCs group concluded26 (28.6%) cases. Ultrasound images and mammograms were reevaluated by breast imaging experts according to the breast imaging reporting and data system (BI-RADS) 4th edition. On mammography, masses margins had significant differences between BBCs group and NBCs group (P = 0.024). Most BBCs margins exhibited microlobulated (30/64, 46.9%) or spiculated (25/64, 39.0%), whereas most NBCs margins exhibited microlobulated (17/23, 73.9%). On ultrasound, BBCs were more frequently to present as larger than 20mm lesions (52/65, 80.0%) and more likely to have angular or spiculated margins (35/65, 53.8%), additionally, compared with NBCs, BBCs were less likely to have calcification (1/65, 1.5%). Other mammography and ultrasound features showed no significant differences between the two groups. In conclusion, we have found some effective features of mammography and ultrasound that could be helpful in differentiating BBC and NBC, which will provide some useful references for clinical diagnosis and treatment.

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Immunohistochemical characteristics of basal-like breast cancer

Cited by 37 publications

References 38 publications

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis

Overexpression of CXXC5 is a strong poor prognostic factor in ER+ breast cancer

Mammography and ultrasound effective features in differentiating basal-like and normal-like subtypes of triple negative breast cancer

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