Immunohistochemical characterization of HSP, α-MSH, Merkel cells and neuronal markers in acute UV dermatitis and acute contact dermatitis in vivo

Bayerl, C.; Lauk, J.; Moll, Ingrid; Jung, Ernst G.

doi:10.1007/s000110050212

Cited by 17 publications

(13 citation statements)

References 6 publications

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“…NGF has been attributed as a key regulatory molecule in the in¯ammatory cascades of various cutaneous disorders such as psoriasis, wound healing and eczematous dermatitis (5,8,10,25). The induction of RANTES by NGF in the keratinocytes as observed in this study provides new information regarding the pro-in¯ammatory functions of NGF.…”

Section: Discussionsupporting

confidence: 55%

Role of Nerve Growth Factor in RANTES Expression by Keratinocytes

Raychaudhuri¹,

Farber

Raychaudhuri

2000

Acta Dermato-Venereologica

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A role of neurogenic inflammation induced by the neuropeptides and nerve growth factor (NGF) has been attributed to the pathogenesis of several cutaneous disorders such as psoriasis, wound healing and eczematous dermatitis. The underlying mechanisms of the inflammatory process induced by NGF are not clearly established. This study explored whether NGF influences the inflammatory process by inducing chemokines. The effects of NGF were investigated on induction of 2 important chemokines, interleukin-8 and RANTES, which are known to be upregulated in the keratinocytes of various inflammatory conditions. NGF significantly increased RANTES production by the keratinocytes (p < 0.001, 2-tailed Student's t-test). Induction of RANTES expression in the keratinocytes by NGF provides further insight regarding the role of NGF-NGF receptor system in cutaneous inflammatory conditions.

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Section: Discussionsupporting

confidence: 55%

Role of Nerve Growth Factor in RANTES Expression by Keratinocytes

Raychaudhuri¹,

Farber

Raychaudhuri

2000

Acta Dermato-Venereologica

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“…MCs have been found to be overexpressed in a variety of neoplastic and inflammatory skin disorders including melanocytic naevi, melanoma, basal cell carcinoma, squamous cell carcinoma, keloids, psoriasis, scarring alopecia and acute UV dermatitis [9, 12, 69, 70]. Regarding pigment lesions immunoreactivity of α-MSH, ACTH and β-ED was more intense and diffuse in samples of nodular melanoma, vertically growing acral lentiginous melanoma, superficial spreading melanoma and metastatic melanomas compared to nevi.…”

Section: Melanocortin and Melanocortin Receptor Expression In Diseasementioning

confidence: 99%

The Role of Melanocortins in Skin Homeostasis

Böhm¹,

Luger²

2000

Horm Res Paediatr

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Melanocortins are structurally related bioactive peptides which are produced by many extra-neural tissues including the skin. All of the melanocortins (α, β, and γ-melanocyte-stimulating hormone and adrenocorticotropin) have melanotropic activity but can elicit many other effects on skin cells. On the basis of in vitro and in vivo findings melanocortins have been shown to regulate immune and inflammatory responses, hair growth, exocrine gland activity and extracellular matrix composition. These effects are mediated by melanocortin receptors among which the melanocortin-1 receptor is most ubiquitously expressed by human skin cells. Simultaneous expression of melanocortins and their receptors suggest a complex autocrine and/or paracrine regulatory network whose disruption invariably affects skin homeostasis. Expression of melanocortin receptors on various skin cell types further indicates novel pharmacological targets for the treatment of skin diseases.

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“…The skin represents one of the well‐known extrapituitary sites of α‐MSH expression and secretion. In addition to its role in melanogenesis, elevated α‐MSH levels have been reported in several cutaneous inflammatory disorders 52–54 . Furthermore, potent anti‐inflammatory properties of α‐MSH have been demonstrated in murine models of delayed‐type hypersensitivity and hapten‐specific tolerance.…”

Section: Anti‐inflammatory Effects Of the MC System In Organ Systems mentioning

confidence: 99%

“…In addition to its role in melanogenesis, elevated ␣-MSH levels have been reported in several cutaneous inflammatory disorders. [52][53][54] Furthermore, potent anti-inflammatory properties of ␣-MSH have been demonstrated in murine models of delayed-type hypersensitivity and hapten-specific tolerance. In this model, epicutaneous application of ␣-MSH inhibited both the induction as well as elicitation phase of contact hypersensitivity response in mice.…”

Section: Skinmentioning

confidence: 99%

Role of the Melanocortin System in Inflammation

Kannengießer

Kucharzik

2006

Annals of the New York Academy of Sciences

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In recent years, scientific interest in melanocortins (MC) has progressively increased due to their wide range of effects and expression on various tissues. Primarily discovered as mediators of skin pigmentation, recent research has shown their important roles in various body functions, such as energy homeostasis, sexual function, and inflammation. The anti-inflammatory and immunomodulatory properties discovered so far have led to the hypothesis that alpha-melanocyte-stimulating hormone (MSH) and its cognate receptors might present potential anti-inflammatory treatment options.

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Immunohistochemical characterization of HSP, α-MSH, Merkel cells and neuronal markers in acute UV dermatitis and acute contact dermatitis in vivo

Abstract: Merkel cells, HSPs and markers of neuroinflammation are of different importance in UV and contact dermatitis in vivo.

Cited by 17 publications

References 6 publications

Role of Nerve Growth Factor in RANTES Expression by Keratinocytes

Role of Nerve Growth Factor in RANTES Expression by Keratinocytes

The Role of Melanocortins in Skin Homeostasis

Role of the Melanocortin System in Inflammation

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