Immunohistochemical Characterization of Mammary Squamous Cell Carcinoma of the Dog

Sassi, Francesco; Sarli, Giuseppe; Brunetti, Barbara; Morandi, Federico; Benazzi, Cinzia

doi:10.1177/104063870802000608

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…CK 19 has been found to detect glandular epithelial cells in canine mammary tumors. The AE3 antibody has already been used in canine tissue sections to identify the luminal epithelium of the normal mammary gland (9,27). Based on these data, our findings confirmed that antibodies "LP34" revealed negative immunostaining for metastatic glandular epithelial cells whereas antibodies "AE1/AE3" revealed strongly positive immunostaining for metastatic glandular epithelial cells in the suspected cases of metastasis of mammary tumors to the skin.…”

Section: Resultssupporting

confidence: 78%

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Histological and immunohistochemical practical studies of canine cutaneous tumors

Šimkus¹,

Petkevičius²,

Pridotkas³

et al. 2016

Medycyna Weterynaryjna

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Section: Resultssupporting

confidence: 78%

“…Similar data proving that antibodies "LP 34" confirm the epithelial origin of the glandular cells have been reported by many researchers (17,18,27).…”

Section: Resultssupporting

confidence: 77%

Histological and immunohistochemical practical studies of canine cutaneous tumors

Šimkus¹,

Petkevičius²,

Pridotkas³

et al. 2016

Medycyna Weterynaryjna

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“…In cases of poorly differentiated carcinomas which lack morphologic features of squamous or glandular differentiation, this distinction between squamous cell carcinoma and adenocarcinoma can be difficult. Molecular methods to aid in this diagnosis specifically within the tonsil have not been investigated in veterinary species; however, similar to other anatomical locations such as the mammary gland, it is possible that positive labelling for cytokeratin19 in glandular carcinomas of the tonsil may differentiate them from squamous cell carcinoma 22 . Salivary carcinomas and oral squamous cell carcinomas with suspected metastases to the tonsil were included when histopathology was consistent with tonsillar tissue.…”

Section: Discussionmentioning

confidence: 99%

Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms

Mickelson

Regan

Randall

et al. 2020

Vet Comparative Oncology

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Tonsillar metastasis from distant primary tumours has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumour metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. ICTL studies (n = 53) were retrospectively reviewed by a single radiologist. Of 882 total tonsil histopathology samples, 492 (56%) were considered neoplastic, with 8% of them benign. Of the primary malignant neoplasms of the tonsil, squamous cell carcinoma (55%), lymphoma (17%) and melanoma (12%) were most common. Tonsillar metastasis was confirmed in 41 cases; histopathologic evaluation revealed melanoma (25), carcinoma (10), hem

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“…Squamous pearls are poorly formed or absent. They are negative for periodic acid Schiff stain and show CK5 and CK6 8,9 positivity. p63 is a sensitive marker for metaplastic carcinomas of the breast especially the squamous type.…”

Section: Discussionmentioning

confidence: 99%

Primary Nonkeratinizing Squamous Carcinoma of Breast With Ipsilateral Axillary Lymph Node Metastasis: A Case Report

Bhat¹,

Vijaya²,

Geethamani³

et al. 2014

jemds

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Primary squamous carcinoma is a rare type of metaplastic carcinoma of the breast, incidence being less than 0.1% of all breast carcinomas. The non-keratinizing variant can mimic several rare types of breast carcinomas, prognosis and therapeutic modalities of which are dissimilar. Histopathological examination is gold standard in diagnosing these tumors. Accurate diagnosis employing special stains and immunohistochemistry is mandatory as they are triple negative unlike infiltrating ductal carcinoma NOS, and have aggressive course, poor prognosis and distinctive treatment modalities. Other unique features include less frequent axillary nodal metastasis and necessity to rule out metastatic squamous carcinomas to the breast from other primary sites in these patients. We present a 60 years old lady with a hard lump in the left breast, with no significant past history. Physical examination was suggestive of carcinoma of breast with axillary lymphadenopathy. Histopathological examination revealed squamous carcinoma of breast positive for p63 and cytokeratin (CK) 5/6. Her chest X-ray, abdominal ultrasonography, oral cavity, laryngobronchoscopy, cystoscopy and cervical Pap smears were unremarkable ruling out the possibility of primary squamous tumor in other common organs. KEYWORDS: Metaplastic carcinoma, non-keratinizing, primary squamous carcinoma, squamous carcinoma of breast. INTRODUCTION:The incidences of primary squamous carcinoma of the breast vary between 0.1% to less than 0.04% of all breast carcinomas. 1-3 'Squamous carcinoma of the breast' refers to a tumor in which more than 90% of the neoplastic cells are squamous. 4 'Pure squamous' carcinomas show only squamous cells. 4 The term 'primary squamous carcinoma' of breast is used when the possibility of metastatic squamous carcinoma is ruled out. 4 Immunohistochemistry and special stains differentiate non-keratinizing squamous carcinoma from its histological mimics. These are very aggressive, treatment refractory tumors with poor prognosis. 3 The modalities of therapy also vary as they are hormone receptor negative. 3 CASE REPORT:A 60 years old post-menopausal woman presented with a painless lump in the left breast since 6 months. There was no history of nipple discharge or skin ulceration. There was no significant past history.Physical examination revealed a hard fixed mass in the upper outer quadrant of left breast measuring 4x3cm. The nipple was retracted. Fine needle aspiration cytology of the lesion revealed carcinoma of breast (Figure 1b). She underwent modified radical mastectomy with axillary clearance.Grossly, the tumor measured 4x2.5cm. The cut surface showed areas of necrosis and cystic change. There were no chondroid or osseous areas. The tumor was completely separate from the adjacent skin, nipple and areola (Figure1a). Six axillary lymph nodes were retrieved.

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Immunohistochemical Characterization of Mammary Squamous Cell Carcinoma of the Dog

Cited by 8 publications

References 20 publications

Histological and immunohistochemical practical studies of canine cutaneous tumors

Histological and immunohistochemical practical studies of canine cutaneous tumors

Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms

Primary Nonkeratinizing Squamous Carcinoma of Breast With Ipsilateral Axillary Lymph Node Metastasis: A Case Report

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