Immunohistochemical Characterization of Thyroid Gland Angiomatoid Tumors

Cutlan, Robert T.; Greer, Jack E.; Wong, Frank S. H.; Eltorky, Mahmoud

doi:10.1006/exmp.2000.2323

Cited by 25 publications

(14 citation statements)

References 22 publications

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“…Immunohistochemical confirmation of the diagnosis of angiosarcoma, even those that are poorly differentiated, can usually be obtained using a panel of vascular markers. Antibody directed against CD31 is still considered the most sensitive and specific marker for endothelial differentiation, being expressed in 90% of angiosarcomas and in slightly more than 1% of carcinomas; the endothelial marker CD34 and the antigen related to factor VIII should also be added to the panel [10,20]. …”

Section: Discussionmentioning

confidence: 99%

Primary thyroid angiosarcoma: an unusual localization

Petronella

Scorzelli

Luise³

et al. 2012

World J Surg Onc

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The finding of thyroid nodules is a very common occurrence in routine clinical practice. Approximately 5% to 7% of the entire population have thyroid nodules. Vascular lesions are one of the most controversial issues in thyroid pathology. These include benign lesions such as hemangiomas and, rarely, malignant tumors such as angiosarcomas or undifferentiated angiosarcomatoid carcinomas. In particular, angiosarcoma of the thyroid gland is a rare, highly aggressive malignant vascular tumor and in Italy the greatest geographical incidence of this lesion is witnessed near the Alps. Here, a case of thyroid angiosarcoma in a 71-year-old man with a history of goiter for about 20 years is described. The unusual localization of this lesion, the difficulties in reaching a definitive diagnosis for this particular histological type of primary tumor and a history of long-standing multinodular goiter in thyroid of an older man from outside the Alpine region prompted us to report this case of thyroid angiosarcoma mainly to discuss surgical, histopathological and immunohistochemical features.

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Section: Discussionmentioning

confidence: 99%

Primary thyroid angiosarcoma: an unusual localization

Petronella

Scorzelli

Luise³

et al. 2012

World J Surg Onc

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“…These immunohistochemical results well corresponded to the sensitive marker of Ulex europaeus 1 lectin and specific marker of factor VIIIrelated antigen (12,13). However, considering immunohistochemical heterogeneity of angiosarcomatoid neoplasm of the thyroid, these immunohistochemical findings simply document the phenotype of the tumor, and does not equate with the definition of the cellular origin (9,14,15). In our opinion, it is more reasonable that the mass should be diagnosed as angiosarcoma admixed with well differentiated follicular carcinoma rather than anaplastic carcinoma or sarcomatoid carcinoma with angiosarcomatous differentiation, because there was neither histological anaplasia in follicular carcinoma portion nor cytokeratin-reactivity in angiosarcoma portion.…”

Section: A B C Dmentioning

confidence: 99%

A Case of Coexistent Angiosarcoma and Follicular Carcinoma of the Thyroid

Kim

Sung

2003

J Korean Med Sci

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High-grade neoplasms of the thyroid with an angiomatoid appearance by light microscopy have been debated for about 100 yr (1), and have not yet been included into the latest World Health Organization (WHO) classification of the thyroid (2). Several authors have described such tumors that display both anaplastic carcinoma and pseudoangiosarcomatous appearance, making difficult the inclusion of these tumors in either the anaplastic carcinoma of the thyroid or conventional angiosarcoma groups of the WHO classification. However, angiosarcoma generally represents a rare connective tissue tumor of the thyroid, and has been designated as malignant hemangioendothelioma by many authors (3, 4), and rarely occurs in that organ. We described a case of an angiosarcoma and well differentiated follicular carcinoma with intervening transitional area. The present report will provide an additional evidence that angiosarcoma of the thyroid is a specific condition of endothelial origin, which is different from angiosarcoma-like anaplastic carcinoma. Here, to confirm the nature of the present tumor, immunohistochemistry and ultrastructural examination were done. CASE REPORTA 64-yr-old-man was admitted due to a painless mass in the anterior region of the neck that had been rapidly growing for several months. 99m Tc thyroid scan showed a cold defect in the right lobe of the thyroid. The results of thyroid function tests were within the normal ranges. He has a history of right pneumonectomy for tuberculosis about 20 yr ago. Fine needle aspiration cytology of the thyroid showed atypical cells showing nuclear pleomorphism and anaplasia, which were suggestive of anaplastic carcinoma. Careful examinations using radiologic methods as well as nuclear medicine did not disclose any metastatic or primary foci, and the tumor was confined within the thyroid region. The patient underwent total thyroidectomy. Two months later, slight dyspnea developed. Skull radiography showed multinodular osteolytic lesions and chest computed tomography showed multifocal bilateral scattered nodules, implying metastatic tumor nodules. He refused further evaluation. Chemotherapy and local radiation therapy were scheduled, but he was lost to follow-up.Grossly, the right lobe and left lobe measured 8×5×3 cm, and 6×3×2 cm. Each weighed 56 g and 20 g. The external A Case of Coexistent Angiosarcoma and Follicular Carcinoma of the ThyroidAngiosarcoma of the thyroid has long been a controversial entity, and it is histologically defined as cleft-like anastosmosing spaces lined by large, atypical cells of endothelial lineage. However, clear-cut separation between the angiosarcoma and anaplastic carcinoma of the thyroid is difficult because they yield nearly the same clinical prognosis and overlapping histologic findings. We report a case of thyroid neoplasm composed of minimally invasive well differentiated follicular carcinoma and angiosarcoma with intervening transitional area. Immunohistochemically, the angiosarcomatous portion showed focal immunoreactivity for endotheli...

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“…One case in which angiosarcoma was thought to be a metastasis in the thyroid was excluded [5]. Follow-up data were available in 46 cases [2,3,4,5,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,27,31,33,34]. Seven cases were unsuccessfully followed-up [2,3,19,28,29], one died of unrelated causes [2], and the remaining four cases had incomplete data.…”

Section: Literature Reviewmentioning

confidence: 99%

Angioinvasion as a factor for predicting aggressive outcome in primary thyroid angiosarcoma: three case reports and literature review

Nechifor-Boilă¹,

Decaussin‐Petrucci²,

Varga-Ilyés³

et al. 2018

pjp

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We report three primary thyroid angiosarcoma (PTA) cases revealing distinctive morphological features. A systematic literature review completed our analysis to evaluate the most important morphological factors for predicting prognosis in PTAs. Three rare PTA cases were analysed. In addition, we identified 46 previously reported PTAs with available follow-up data to compare morphological features related to prognosis between patients with a favourable versus aggressive outcome. The three PTAs displayed considerable architectural heterogeneity: case 1 presented a well circumscribed tumour, extensively necrotic, with only a few highly pleomorphic vascular proliferation; cases 2 and 3 both exhibited plump epithelioid cells forming rudimentary vascular spaces or solid sheets. Case 3 also presented angioinvasion. Cases 1 and 2 were alive and disease-free at 40 and 73 months following diagnosis, respectively, whereas case 3 died within 14 months. Other significant prognostic factors were highlighted by our review and literature data analysis: increased tumour size (p = 0.042), extrathyroidal extension (p = 0.009), and distant metastases at diagnosis (p = 0.001). Although regarded as highly aggressive, PTA can also be characterised by an unusual favourable outcome. For the first time we highlight the importance of reporting angioinvasion, in cases of PTA, as a possible adverse prognostic factor.

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Immunohistochemical Characterization of Thyroid Gland Angiomatoid Tumors

Cited by 25 publications

References 22 publications

Primary thyroid angiosarcoma: an unusual localization

Primary thyroid angiosarcoma: an unusual localization

A Case of Coexistent Angiosarcoma and Follicular Carcinoma of the Thyroid

Angioinvasion as a factor for predicting aggressive outcome in primary thyroid angiosarcoma: three case reports and literature review

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