Immunohistochemical characterization of wound healing at two different bone graft substitutes

Sager, Martin; Ferrari, Daniel; Wieland, Marco; Dard, Michel; Becker, Jürgen; Schwarz, Frank

doi:10.1016/j.ijom.2011.11.017

Cited by 12 publications

(11 citation statements)

References 43 publications

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“…Likewise, both groups showed a similar immunohistochemical reactivity for the mineralization marker osteocalcin, as found previously in studies that demonstrated the osteoconductivity of BCP in straightforward dehiscence‐type defects around implants (Sager et al. ; Schwarz et al. ).…”

Section: Discussionsupporting

confidence: 85%

Pre‐augmentation soft tissue expansion improves scaffold‐based vertical bone regeneration – a randomized study in dogs

Kaner

Zhao

Arnold

et al. 2016

Clinical Oral Implants Res

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ObjectiveSoft tissue (ST) dehiscence with graft exposure is a frequent complication of vertical augmentation. Flap dehiscence is caused by failure to achieve tension‐free primary wound closure and by the impairment of flap microcirculation due to surgical trauma.Soft tissue expansion (STE) increases ST quality and quantity prior to reconstructive surgery. We hypothesized that flap preconditioning using STE would reduce the incidence of ST complications after bone augmentation and that optimized ST healing would improve the outcome of bone regeneration.Materials and methodsSelf‐filling tissue expanders were implanted in mandibular bone defects in ten beagle dogs. After expansion, alloplastic scaffolds were placed for vertical bone augmentation in STE sites and in control sites without STE pre‐treatment. ST flap microcirculation was analysed using laser Doppler flowmetry. The incidence of graft exposures was evaluated after 2 weeks. Bone formation was assessed after 2 months, using histomorphometry and immunohistochemistry.ResultsTest sites showed significantly less impairment of perfusion and faster recovery of microcirculation after bone augmentation. Furthermore, no flap dehiscences occurred in STE sites. Bone regeneration was found in both groups; however, significantly greater formation of new bone was detected in test sites with preceding STE.ConclusionsPreconditioning using STE improved ST healing and bone formation after vertical augmentation. The combination of STE and the subsequent placement of alloplastic scaffolds may facilitate the reconstruction of severe bone defects.

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Section: Discussionsupporting

confidence: 85%

Pre‐augmentation soft tissue expansion improves scaffold‐based vertical bone regeneration – a randomized study in dogs

Kaner

Zhao

Arnold

et al. 2016

Clinical Oral Implants Res

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“…The block form in particular has been demonstrated to be more efficient than granular form with new bone apposition occurring as the material degrades . Two recent studies of standard buccal dehiscence‐type defects surgically created following implant bed preparation in dental implants using a dog model demonstrated the bone remodeling and graft resorption characteristics of BCP . Dehiscence defects involve the loss of aveolar bone on the buccal (rarely lingual) aspect of the tooth that leaves a characteristic oval root exposure from the cement enamel junction.…”

Section: Preclinical Investigations—in Vivomentioning

confidence: 99%

“…BCP grafts in block form would also be deemed more effective in such locations for maintaining defect space but rather providing a physical bridging scaffold between the surrounding defect walls. Interestingly, in surgically prepared osseous periodontal defects, dehiscence‐type defects greater gains in new bone formation with higher ratios of HA to β‐TCP were seen . Periodontal defects are healed by invading stem cells from surrounding bone that need to differentiate not only into bone but also periodontal ligament.…”

Section: Preclinical Investigations—in Vivomentioning

confidence: 99%

“…137 Two recent studies of standard buccal dehiscence-type defects surgically created following implant bed preparation in dental implants using a dog model demonstrated the bone remodeling and graft resorption characteristics of BCP. 138,139 Dehiscence defects involve the loss of aveolar bone on the buccal (rarely lingual) aspect of the tooth that leaves a characteristic oval root exposure from the cement enamel junction. Defects were filled with a biphasic HA:b-TCP (60:40) or collagen-coated natural bone mineral and covered with a native collagen membrane.…”

Section: Composition Of Bcpsmentioning

confidence: 99%

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Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

2017

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Bone is a composite material composed of collagen and calcium phosphate (CaP) mineral. The collagen gives bone its flexibility while the inorganic material gives bone its resilience. The CaP in bone is similar in composition and structure to the mineral hydroxyapatite (HA) and is bioactive, osteoinductive and osteoconductive. Therefore synthetic versions of bone apatite (BA) have been developed to address the demand for autologous bone graft substitutes. Synthetic HA (s-HA) are stiff and strong, but brittle. These lack of physical attributes limit the use of synthetic apatites in situations where no physical loading of the apatite occurs. s-HA chemical properties differ from BA and thus change the physical and mechanical properties of the material. Consequently, s-HA is more chemically stable than BA and thus its resorption rate is slower than the rate of bone regeneration. One solution to this problem is to introduce a faster resorbing CaP, such as β-tricalcium phosphate (β-TCP), when synthesizing the material creating a biphasic (s-HA and β-TCP) formulation of calcium phosphate (BCP). The focus of this review is to introduce the major differences between BCP and biological apatites and how material scientists have overcome the inadequacies of the synthetic counterparts. Examples of BCP performance in vitro and in vivo following structural and chemical modifications are provided as well as novel ultrastructural data. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2493-2512, 2018.

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“…12 A few years ago, 100% synthetic and bioinert biomaterial made 60% of HA (100% crystalline) and 40% of b-TCP, synthesized at 1,100 to 1,500 °C (Straumann BoneCeramic), was introduced into the market with promises of promoting periodontal and peri-implant regenerative bone therapy. 13 This biomaterial has been investigated by immunohistochemical studies; 14,15 animal studies investigating alveolar defects; 14,16 and clinical studies on maxillary sinus lift, 12,17 lateral alveolar ridge augmentation 18 and periodontal defects; 19,20,21 all of which found it to be clinically feasible as an osteoconductive material.…”

Section: Introductionmentioning

confidence: 99%

Bilateral sinus floor augmentation using 100% alloplastic biomaterial for later rehabilitation of atrophic maxilla. A 5-year tomographic follow-up

Bucco¹,

Silva²,

Miranda³

et al. 2015

Dental Press Implantol

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Immunohistochemical characterization of wound healing at two different bone graft substitutes

Cited by 12 publications

References 43 publications

Pre‐augmentation soft tissue expansion improves scaffold‐based vertical bone regeneration – a randomized study in dogs

Pre‐augmentation soft tissue expansion improves scaffold‐based vertical bone regeneration – a randomized study in dogs

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

Bilateral sinus floor augmentation using 100% alloplastic biomaterial for later rehabilitation of atrophic maxilla. A 5-year tomographic follow-up

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