Immunohistochemical Correlation of Novel Biomarkers with Neurodegeneration in Rat Models of Brain Injury

Gajavelli, Shyam; Bregy, Amadé; Spurlock, Markus S.; Diaz, David; Burks, S. Shelby; Bomberger, Christine; Bidot, Carlos; Yokobori, Shoji; Díaz, J. F. Jiménez; Sanchez-Chavez, Jose; Bullock, Ross

doi:10.5772/34184

Applications of Immunocytochemistry 2012

DOI: 10.5772/34184

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Immunohistochemical Correlation of Novel Biomarkers with Neurodegeneration in Rat Models of Brain Injury

Shyam Gajavelli¹,

Amadé Bregy²,

Markus S. Spurlock³

et al.

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2014

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Cited by 1 publication

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Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury

Gajavelli

Sinha

Mazzeo

et al. 2014

J Bioenerg Biomembr

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Traumatic brain injury (TBI) is still the leading cause of disability in young adults worldwide. The major mechanisms - diffuse axonal injury, cerebral contusion, ischemic neurological damage, and intracranial hematomas have all been shown to be associated with mitochondrial dysfunction in some form. Mitochondrial dysfunction in TBI patients is an active area of research, and attempts to manipulate neuronal/astrocytic metabolism to improve outcomes have been met with limited translational success. Previously, several preclinical and clinical studies on TBI induced mitochondrial dysfunction have focused on opening of the mitochondrial permeability transition pore (PTP), consequent neurodegeneration and attempts to mitigate this degeneration with cyclosporine A (CsA) or analogous drugs, and have been unsuccessful. Recent insights into normal mitochondrial dynamics and into diseases such as inherited mitochondrial neuropathies, sepsis and organ failure could provide novel opportunities to develop mitochondria-based neuroprotective treatments that could improve severe TBI outcomes. This review summarizes those aspects of mitochondrial dysfunction underlying TBI pathology with special attention to models of penetrating traumatic brain injury, an epidemic in modern American society.

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Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury

Gajavelli

Sinha

Mazzeo

et al. 2014

J Bioenerg Biomembr

View full text Add to dashboard Cite

show abstract

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Immunohistochemical Correlation of Novel Biomarkers with Neurodegeneration in Rat Models of Brain Injury

Cited by 1 publication

References 32 publications

Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury

Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury

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