Immunohistochemical Detection of Female Sex Hormone Receptors in Meningiomas

Brandis, Almuth; Mirzai, Shahram; Tatagiba, Marcos; Walter, Gerhard; Samii, Madjid; Ostertag, Helmut

doi:10.1097/00006123-199308000-00005

Cited by 51 publications

(44 citation statements)

References 44 publications

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“…10) The progesterone receptor is expressed in 61% to 95% of meningiomas, and the estrogen receptor in 0% to 8.6% of the tumor. 1,9,20) Based on the reported relationship between the progesterone receptor expression and a good prognosis, hormonal therapy has been tried for the treatment of meningiomas. 9) Endocrine manipulation of meningiomas in vitro was mainly attempted using medroxyprogesterone acetate as an agonist of the progesterone receptor in the 1980s, [13][14][15]22) but no clinical efficacy could be confirmed.…”

Section: Discussionmentioning

confidence: 99%

“…11) Previous studies have reported the expression of sex hormone receptors in meningiomas. 1,9,20) Meningiomas reportedly enlarge when the serum levels of progesterone are elevated during pregnancy or the luteral phase of menstrual cycle in women. 9) Here we report a male patient with spontaneous regression of an asymptomatic meningioma associated with discontinuation of progesterone agonist administration that he was receiving for the treatment of benign prostatic hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Regression of an Asymptomatic Meningioma Associated With Discontinuation of Progesterone Agonist Administration -Case Report-

Shimizu

Matsumoto

Yamazaki

et al. 2008

Neurol. Med. Chir.(Tokyo)

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An 80-year-old male visited the hospital as an outpatient with a head injury sustained in a traffic accident. Brain computed tomography incidentally revealed a left frontal lobe tumor measuring 5 cm in a diameter. The patient had a history of taking chlormadinone acetate (a progesterone agonist) prescribed several years previously as treatment for benign prostatic hypertrophy. The tumor was seen as an isointense lesion on T 1 -weighted magnetic resonance (MR) images with enhancement by gadolinium, and as a heterogeneously hyperintense mass on T 2 -weighted MR images. The tentative diagnosis was left frontal meningioma attached to the sphenoid ridge or sphenoid plane. The patient was managed conservatively because of his advanced age and no symptoms or progression were observed during a 9-month follow-up period. The medication for benign prostatic hypertrophy was changed from chlormadinone acetate to naftopidil (an alpha-2-blocker) about 9 months after his first presentation. The patient presented again 2 years later complaining of dizziness. Computed tomography and MR imaging performed at this time revealed remarkable regression of the tumor. The signal intensity change with regression of the tumor on T 2 -weighted images was observed as a hypointense lesion. Thus, we wish to emphasize that treatment of meningiomas, especially those diagnosed incidentally, must be based on a thorough consideration of any history of hormonal therapy with prostate disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spontaneous Regression of an Asymptomatic Meningioma Associated With Discontinuation of Progesterone Agonist Administration -Case Report-

Shimizu

Matsumoto

Yamazaki

et al. 2008

Neurol. Med. Chir.(Tokyo)

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“…Brandis et al 28 studied 53 typical tumors and 8 non-typical and found differences only for men. Recently, Hsu et al 9 suggested that absence of PR, high mitotic index and higher tumor grade were significant factors for shorter disease-free interval and that the presence of PR, even in a small number of tumor cells, is a favorable prognostic factor for meningiomas.…”

Section: Discussionmentioning

confidence: 99%

Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Hilbig

Barbosa-Coutinho

1998

Arq. Neuro-Psiquiatr.

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-The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3% of typical, and in 48.2% of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.KEY WORDS: meningioma, progesterone receptor, estrogen receptor, immunohistochemistry. Meningiomas e receptores hormonais: estudo imuno-histoquímico em tumores típicos e não típicosRESUMO -Os autores avaliam 116 meningiomas classificados em típicos, atípicos ou anaplásicos usando técnica imuno-histoquímica para receptores de estrógeno (ER) e progesterona (PR) com o objetivo de determinar se existe diferença entre tumores típicos e não típicos em relação aos receptores hormonais. Todos os tumores estudados foram negativos para ER. Os receptores de progesterona foram detectados em 58,3% dos meningiomas típicos e em 48,2% dos tumores não-típicos. Essa diferença não foi estatisticamente significativa. Entretanto, considerando os critérios utilizados para seleção dos não-típicos, os tumores que apresentavam, de forma concomitante, invasão do sistema nervoso central e aumento da taxa mitótica ou necrose, bem como a soma das três características, foram predominantemente negativos para PR (p=0,038; 0,01 e 0,044, respectivamente). Os autores concluem que: ERs não estão presentes em meningiomas; PRs estão presentes na maioria dos meningiomas; a negatividade para PR isoladamente não é suficiente para predizer maior malignidade mas pode ser útil se associada a outras características histológicas. PALAVRAS-CHAVE: meningioma, receptores de progesterona, receptores de estrógeno, imunohistoquímica.Meningiomas are the most common meningeal tumors of the central nervous system. These tumors arise from the arachnoidial layer of meninges and, although they are generally benign, there are many cases showing atypical and anaplastic features 1 . Epidemiological data suggest that female sex hormones may play a role in the growth of meningiomas. They show a higher incidence in

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“…Regarding female sex hormone receptors, a tendency for tumors without progesterone receptors to have larger sizes has also been documented 3 …”

Section: Discussionmentioning

confidence: 99%

Analysis of the influence of the variable size on the characteristics and behavior of meningiomas

et al. 2005

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Análisis de la influencia de la variable tamaño en las características y comportamiento de los meningiomas ResumenSe han revisado setenta y dos enfermos sometidos a cirugía de meningioma en el Hospital Pedro Hispano entre 1997 y 2001, para evaluar la asociación entre el tamaño (mayor diámetro de la lesión obtenido a partir de los exámenes de imagen) y otras variables concernientes a la caracterización y comportamiento de la lesión. Se han encontrado asociaciones, con significación estadística, con la localización, tipo de primer síntoma, tipo de examen físico, grado histológico, aparición de complicaciones, bolsas de LCR y transfusiones de sangre. La edad, el sexo, la duración de primer síntoma, el estado al alta hospitalaria y los síntomas persistentes no se relacionan con el tamaño. Se encontró alguna relación con el tipo de exéresis y señales persistentes. Se discuten las causas e implicaciones de los hallazgos. El tamaño es un parámetro que puede interferir en la capacidad del neurocirujano para tratar estos pacientes y en la capacidad de recuperación de los mismos."PALABRAS CLAVE: Meningioma. Tamaño. Característi-cas. Comportamiento. Correlación.

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Immunohistochemical Detection of Female Sex Hormone Receptors in Meningiomas

Cited by 51 publications

References 44 publications

Spontaneous Regression of an Asymptomatic Meningioma Associated With Discontinuation of Progesterone Agonist Administration -Case Report-

Spontaneous Regression of an Asymptomatic Meningioma Associated With Discontinuation of Progesterone Agonist Administration -Case Report-

Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors

Analysis of the influence of the variable size on the characteristics and behavior of meningiomas

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