Immunohistochemical detection of parathyroid hormone-related protein in a rare variant of hepatic neoplasm (sclerosing hepatic carcinoma)

Albar, Juan Pablo; Miguel, Fernando de; Esbrit, Pedro; Miranda, Ramiro; Fernández-Flores, Ángel; Sarasa, José Luis Andrès

doi:10.1016/s0046-8177(96)90405-0

Cited by 26 publications

(17 citation statements)

References 10 publications

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“…In our case, the scirrhous type HCC had intense fibrosis and no tumor capsule or necrosis, which was similar to results of previous studies (3,10), whereas the classic HCC showed a partial capsule. Clinically, scirrhous HCC usually develops in patients with chronic liver disease and occasionally releases parathyroid hormone-related protein, resulting in hypercalcemia and hypophosphatemia (3,4,9,11). Our subject had early cirrhotic liver but showed normal levels of calcium and phosphate.…”

Section: Discussionmentioning

confidence: 77%

Synchronous Occurrence of Classic and Scirrhous Hepatocellular Carcinomas: A Case Report

et al. 2018

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Scirrhous hepatocellular carcinoma (HCC) is a subtype of HCC that is characterized by abundant fibrous stroma admixed with tumor cells. Although imaging findings of scirrhous HCC differ from those of classic HCC, it is difficult to diagnose this rare neoplasm. Like classic HCC, scirrhous HCC frequently develops in patients with liver cirrhosis, but there has been no report of synchronous occurrence of classic and scirrhous HCCs. Here, we report synchronous classic and scirrhous HCCs in a 62-year-old man with early liver cirrhosis who underwent gadoxetic acid-enhanced and diffusion-weighted magnetic resonance imaging.

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Section: Discussionmentioning

confidence: 77%

Synchronous Occurrence of Classic and Scirrhous Hepatocellular Carcinomas: A Case Report

et al. 2018

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“…Sclerosing HCC is frequently associated with hypercalcemia and hypophosphatemia, which may be related to the parathyroid hormone-related protein produced by the tumor [17]. This tumor type appears as a heterogeneous echoic mass on ultrasound.…”

Section: Sclerosing Hccmentioning

confidence: 99%

Hepatocellular Carcinoma Variants: Radiologic-Pathologic Correlation

Chung

Park

et al. 2009

American Journal of Roentgenology

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W7poorer prognosis than classic HCC, whereas fibrolamellar HCC shows better prognosis and sclerosing HCC shows prognosis similar to classic HCC [5][6][7]. Radiologically, these variants do not share imaging characteristics typical of HCC.The diagnosis of HCC larger than 2 cm can be made without biopsy if a mass in a cirrhotic liver shows the typical features of HCC on contrast-enhanced CT or MRI and the α-fetoprotein level is greater than 200 ng/mL [8]. In the case of HCC with atypical imaging features, however, this guideline cannot be applied. Therefore, recognizing these variants and their imaging features has clinical consequences, even though a preoperative biopsy is still needed because these variants cannot be completely differentiated from other tumors by imaging only.In this article, we collectively review and illustrate the radiologic findings for variant types of HCC and correlate these findings with pathologic analyses. HCC, Predominantly Clear Cell TypeCytoplasmic fat is frequently present in well-differentiated HCC and is abundant in approximately 10% of cases. A large amount of cytoplasmic fat or glycogen can cause the cytoplasm to appear white in routine pathologic sections, producing a "clear cell" appearance. On microscopy, 19.6% of HCCs have been reported to have cytoplasmic fat. On imaging, however, only 1.6% of cases have been reported to show a cytoplasmic fat component [9]. HCCs with a clear cell appearance frequently show increased echogenicity on sonography and decreased attenuation on is the most common form of primary hepatic tumor and its incidence has increased in recent years. The risk factors for HCC are well established and include viral hepatitis, alcoholic liver cirrhosis, and exposure to hepatotoxins. The typical sonographic and unenhanced CT findings of HCC show a well-circumscribed hypoechoic or hypoattenuated mass with or without the hypoechoic rim of a tumor capsule. MRI typically shows that HCC is hyperintense relative to the liver on T2-weighted images and hypointense on T1-weighted images. On dynamic CT and MRI, HCC shows early enhancement in the arterial phase and contrast medium washout in the equilibrium phase. Equilibrium phase CT and MRI could show a thin rim-enhancing tumor capsule with variable incidence, ranging from 10% to 80.7% of the cases, depending on the series [1]. G a s t r oi nt e s t i n a l I m ag i ng • Pic t o r i a l E s s ayAlthough the prevalence is variable depending on the series, hemorrhage or calcification (~ 5%), central scar (~ 3%), or gross fat (~ 1.6%) may be seen within the HCC tumor [2]. HCC in noncirrhotic patients usually manifests as either a large solitary mass or a dominant mass with small satellite nodules that more frequently shows necrosis and central scar formation than HCC in cirrhotic patients [3].

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“…Rabbit polyclonal Ab-IV antibody to PTH1R was from Covance (Berkeley, CA, USA). PTHrP was detected by rabbit polyclonal antiserum C6 recognizing the C-terminal (107-111) epitope in the intact PTHrP molecule (Albar et al 1996 …”

Section: Reagentsmentioning

confidence: 99%

Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in human prostate cancer cells

et al. 2009

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Immunohistochemical detection of parathyroid hormone-related protein in a rare variant of hepatic neoplasm (sclerosing hepatic carcinoma)

Cited by 26 publications

References 10 publications

Synchronous Occurrence of Classic and Scirrhous Hepatocellular Carcinomas: A Case Report

Synchronous Occurrence of Classic and Scirrhous Hepatocellular Carcinomas: A Case Report

Hepatocellular Carcinoma Variants: Radiologic-Pathologic Correlation

Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in human prostate cancer cells

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