Immunohistochemical differentiation of eosinophilic heart diseases using antibodies against eosinophil activation markers

Abstract

The immunohistochemical investigation of eosinophilic heart diseases using antibodies against CD69 can be a useful tool to distinguish between hypersensitivity myocarditis and endocarditis parietalis fibroplastica.

Fatal carbamazepine induced fulminant eosinophilic (hypersensitivity) myocarditis: Emphasis on anatomical and histological characteristics, mechanisms and genetics of drug hypersensitivity and differential diagnosis

“…HeoM on the other hand shows predominant endomyocardial damage, prominent necrosis and fibrosis and non allergic, CD69 negative eosinophils. 29 GCM is a rare and often rapidly fatal form of myocarditis of unknown aetiology. The majority of patients present with congestive cardiac failure or conduction disturbances.…”

Myocardial ischemic injury derived from multiple thromboemboli due to eosinophilic endomyocarditis (Löffler endocarditis) causing right ventricular rupture

“…According to histological classification in HES, EEC is classified as the first necrotic stage with eosinophil-rich myocarditis and endocardial damage, the second thrombotic stage with mural thrombogenesis, and the third fibrotic stage. 2,4 This case presented the lesions at the first and second stages.…”

“…1,2 EEC with an unidentified cause, referred to as idiopathic hypereosinophilic syndrome (HES), 1 frequently involves the heart 2,3 and typically presents with congestive heart failure. 1,3,4 Here we report the first case of an elderly male who suddenly died of cardiac tamponade due to right ventricle (RV) rupture in association with EEC.…”

Eosinophilic myocarditis presenting as acute myocardial infarction

“…Of these subtypes, EPF has a predominantly malignant clinical course, often progressing to heart failure and death, whereas hypersensitivity myocarditis tends to be a more benign condition. 4 In terms of clinical manifestation, cardiac involvement in eosinophilic myocarditis can be insidious or present more unusually, as in this case, with features indistinguishable from acute coronary syndrome (ACS). More typically the presenting features are not those immediately associated with cardiac aetiology, such as general malaise, weight loss and fevers.…”