Immunohistochemical Distinction of Follicular Thyroid Adenomas and Follicular Carcinomas

Bryson, Paul C.; Shores, Carol G.; Hart, Craig F.; Thorne, Leigh B.; Patel, Mihir R.; Richey, Luke M.; Farag, Alexander; Zanation, Adam M.

doi:10.1001/archotol.134.6.581

Cited by 49 publications

(36 citation statements)

References 22 publications

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“…Some studies have suggested trefoil factor 3 (TFF3) as a useful biomarker at the RNA level in thyroid cancer, and this gene was listed as 1 of 12 (of a total of 1795 genes) to have the most clinical promise (based on results of the array analysis) for the preoperative thyroid diagnosis (Griffith et al, 2006). IHC results of another study did not substantiate the anticipated promise of TFF3 as a clinical marker (Bryson et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Differential diagnosis between FTA and FTC is based on presence of capsular or vascular invasion in carcinoma (Rosai, 2011;Bryson et al, 2008) which cannot be evaluated in material obtained from thyroid fine needle aspiration biopsy (Goldstein et al, 2002). Suspicious nodules must therefore be surgically removed in subtotal or total thyroidectomy.…”

Section: Discussionmentioning

confidence: 99%

“…However, DNA microarray gene profiling is expensive, time consuming, and operator dependent and therefore not practical for clinical use (Bryson et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…A multicenter study demonstrated that IHC detection of galectin-3 (an enzyme regulating cell-cell communication and implicated in the initiation and regulation of cell growth and malignant transformation) in FNA biopsy samples from thyroid nodules served as a highly specific and sensitive means of identifying malignant lesions of the thyroid ( Bartolazzi et al, 2001). Other studies disprove the utility of galectin-3 as a single protein marker, especially in the case of follicular lesions (Bryson et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…One of the most challenging tasks in pathologic evaluation of thyroid lesions, is the differentiation between FTC and FTA. Diagnosis of FTC is dependent on the presence of capsular or vascular invasion (Rosai, 2011;Bryson et al, 2008) .Fine needle aspiration biopsy is not capable to discriminate between FTA and FTC based on the mentioned criteria (Goldstein et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Expression of Matrix Metalloproteinase-2, but not Caspase-3, Facilitates Distinction between Benign and Malignant Thyroid Follicular Neoplasms

Sanii¹,

Saffar²,

Tabriz³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…However, DNA microarray gene profiling is expensive, time consuming, and operator dependent and therefore not practical for clinical use (Bryson et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Expression of Matrix Metalloproteinase-2, but not Caspase-3, Facilitates Distinction between Benign and Malignant Thyroid Follicular Neoplasms

Sanii¹,

Saffar²,

Tabriz³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Trefoil Factor 3 Immunohistochemical Characterization of Follicular Thyroid Lesions From Tissue Microarray

Patel

Bryson²,

Shores³

et al. 2009

Archives of Otolaryngology - Head and Neck Surgery

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Protein expression data validate gene expression findings that follicular neoplastic lesions have decreased expression of TFF3 compared with that in normal thyroid tissue samples. These findings contribute to evidence suggesting that TFF3 may have a role in normal thyroid tissue function and that thyroid carcinomas may have reduced expression of TFF3, in contradistinction to other carcinomas that overexpress TFF3.

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The quest for diagnostic molecular markers for thyroid nodules with indeterminate or suspicious cytology

Kouniavsky

Zeiger

2012

Journal of Surgical Oncology

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Thyroid nodules are very common and fine needle aspiration (FNA) is a very sensitive means of diagnosis. However, its limitations include the fact that the cytology reports are often indeterminate or suspicious only. The quest for adjunctive measures to improve its specificity has been ongoing for decades, but significant results have remained elusive. The potential use of diagnostic molecular markers appears to be the most promising area of research at this time.

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Immunohistochemical Distinction of Follicular Thyroid Adenomas and Follicular Carcinomas

Cited by 49 publications

References 22 publications

Expression of Matrix Metalloproteinase-2, but not Caspase-3, Facilitates Distinction between Benign and Malignant Thyroid Follicular Neoplasms

Expression of Matrix Metalloproteinase-2, but not Caspase-3, Facilitates Distinction between Benign and Malignant Thyroid Follicular Neoplasms

Trefoil Factor 3 Immunohistochemical Characterization of Follicular Thyroid Lesions From Tissue Microarray

The quest for diagnostic molecular markers for thyroid nodules with indeterminate or suspicious cytology

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