Immunohistochemical Distinction of Primary Sweat Gland Carcinoma and Metastatic Breast Carcinoma

Mentrikoski, Mark J.; Wick, Mark R.

doi:10.1309/ajcp2n1afxefovye

Cited by 38 publications

(43 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One of the invasive adenocarcinomas in vulvar type Ic EMPDs in our study was an eccrine carcinoma. Cutaneous eccrine carcinomas were positive for GATA3 in 36% to 68% cases [68, 69]. The only eccrine carcinoma in our study showed 4+ GATA3 staining (>75% cells).…”

Section: Discussionmentioning

confidence: 53%

See 1 more Smart Citation

GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

et al. 2017

View full text Add to dashboard Cite

BackgroundGATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied.MethodsHere we investigated immunohistochemical expression of GATA3 in 72 primary genital EMPDs (35 from female, 37 from male; 45 with intraepithelial disease only, 26 with both intraepithelial disease and invasive adenocarcinoma including 14 also metastasis, 1 with metastatic adenocarcinoma only for study). We also compared GATA3 to gross cystic disease fluid protein 15 (GCDFP15) for their sensitivity.ResultsPositive GATA3 staining was seen in all 71 (100%) intraepithelial diseases, 25/26 (96%; female 10/10, male 15/16) invasive adenocarcinomas and 14/15 (93%; female 3/3, male 11/12) metastatic adenocarcinomas, respectively. Positive GCDFP15 staining was seen in 46/71 (65%; female 28/34 or 82%, male 18/37 or 49%) intraepithelial diseases, 20/26 (77%; female 9/10, male 11/16) invasive adenocarcinomas, and 12/15 (80%; female 2/3, male 10/12) metastatic adenocarcinomas, respectively (GATA3 versus GCDFP15: p < 0.01 for both intraepithelial disease and invasive adenocarcinoma, p = 0.28 for metastatic adenocarcinoma). In positive-stained cases, GATA3 stained more tumor cells than GCDFP15 (79% versus 25% for intraepithelial disease, 71% vs 34% for invasive adenocarcinoma, 73% vs 50% for metastatic adenocarcinoma, p < 0.01 for all 3 components).ConclusionsOur findings indicate that GATA3 is a very sensitive marker for primary genital EMPDs and is more sensitive than GCDFP15.

show abstract

Section: Discussionmentioning

confidence: 53%

“…Their distinction relies on morphology and other markers such as p63 and GCDFP15. Eccrine carcinomas were often positive p63 (85% to 89%) whereas primary type Ib EMPDs were not [68, 69]. Eccrine carcinomas were only rarely positive for GCDFP15 (5%) [69].…”

Section: Discussionmentioning

confidence: 99%

GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The most useful histological features supporting a diagnosis of SMBC rather than primary cutaneous SGC are location of the tumor in the deep dermis or subcutaneous tissue, multifocality and lymphovascular invasion, but these features are not always entirely reliable . Making a differential diagnosis between SGC and SMBC is usually difficult to impossible based on morphological analysis of hematoxylin–eosin (HE)‐stained specimens alone . This is not surprising because the breast and the sweat glands, especially apocrine glands, are functional and structural homologs.…”

Section: Sweat Gland Neoplasmsmentioning

confidence: 99%

“…However, these antibodies are usually also positive in benign and malignant sweat gland tumors, and thus fail to distinguish SMBC with high sensitivity and specificity. Recently, other antibodies have been examined for this purpose, including anti‐p63, cytokeratin (CK)5/6, podoplanin (D2‐40) and mammaglobin (MMG) antibody …”

Section: Sweat Gland Neoplasmsmentioning

confidence: 99%

Topics in histopathology of sweat gland and sebaceous neoplasms

Ansai

2017

The Journal of Dermatology

View full text Add to dashboard Cite

This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117 can help to distinguish sweat gland or sebaceous tumors from other non-Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of antibodies may be useful, including p63 (SGC + , SMBC ). Comparison of antibodies used for immunohistochemical diagnosis of sebaceous carcinoma (SC) suggests that adipophilin has the highest sensitivity and specificity. Some authors have found that immunostaining for survivin, androgen receptor and ZEB2/ SIP1 has prognostic value for ocular SC, but not extraocular SC. In situ SC is rare, especially extraocular SC, but there have been several recent reports that actinic keratosis and Bowen's disease are the source of invasive SC. Finally, based on recent reports, classification of sebaceous neoplasms into three categories is proposed, which are sebaceoma (a benign neoplasm with well-defined architecture and no atypia), borderline sebaceous neoplasm (low-grade SC; an intermediate tumor with well-defined architecture and nuclear atypia) and SC (a malignant tumor with invasive growth and evident nuclear atypia).

show abstract

“…Importantly, ER and PR are often negative in higher-grade breast cancers and rare morphologic variants. In such cases, a panel including p63, CK5/6 and D2-40 reportedly helps differentiate breast and adnexal neoplasia, although these stains are not entirely specific [39,40,41]. …”

Section: Discussionmentioning

confidence: 99%

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

Rooper

Iding

Cuda³

et al. 2016

Acta Cytologica

View full text Add to dashboard Cite

Background: Fine-needle aspiration (FNA) is well-established as an accurate technique for the diagnosis of palpable breast masses. While the differential diagnosis of such lesions usually focuses on benign or malignant mammary proliferations, a subset of breast neoplasms arises from skin and soft tissue. Skin adnexal neoplasms such as hidradenoma can pose a particular pitfall on breast FNA cytology (FNAC) as epithelial proliferations that are not of ductal or lobular origin. Case: A 59-year-old female presented with a superficial breast mass. FNAC revealed a hypercellular lesion with marked nuclear atypia that was highly suspicious for carcinoma. However, at partial mastectomy, the histological features of the tumor were consistent with atypical hidradenoma. Negativity for estrogen receptor (ER) and progesterone receptor (PR) confirmed the diagnosis. Eighteen years later, the patient remains free of recurrence or metastasis. Conclusions: This report offers the first description of findings of atypical hidradenoma on FNAC. In the breast, its high cellularity and nuclear atypia can mimic a primary mammary carcinoma on FNAC. Although breast and skin adnexal tumors show a immunohistochemical overlap, negative ER and PR stains in a low-grade tumor can suggest a nonmammary lesion. Skin adnexal neoplasms should be considered in the differential diagnosis of superficial breast tumors.

show abstract

Immunohistochemical Distinction of Primary Sweat Gland Carcinoma and Metastatic Breast Carcinoma

Cited by 38 publications

References 28 publications

GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15

Topics in histopathology of sweat gland and sebaceous neoplasms

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

Contact Info

Product

Resources

About